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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 401–425 of 27,380 studies, newest first · page 17 of 1096.

September 2026 25

  1. 2026-09-21

    Phosphorylated tau 217 in young adults with Down syndrome and Down syndrome regression disorder

    ✓ Peer-reviewed Down syndrome and Alzheimer's Communications medicine

    Key finding: These findings provide no evidence of a group-level Alzheimer-related p-tau217 elevation in young people with DSRD and support DSRD as a condition distinct from Alzheimer's disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2026-09-21

    Clinical and attitudinal outcomes of a personalized, multimodal lifestyle intervention for Alzheimer's disease prevention in high-risk, cognitively normal older adults in north Alabama: A pilot study

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

    Key finding: A composite rubric classified high-risk status (score >5 and/or pTau217 >0.18 pg/mL); high-risk participants received results disclosure and a 6-month personalized intervention (dietitian-led coaching, cognitive training, activity tracking). +2 more findings

    Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  3. 2026-09-21

    Smartphone Passive Digital Phenotyping in Frontotemporal Lobar Degeneration

    ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv (preprint)

    Key finding: IntroductionFrontotemporal lobar degeneration (FTLD) is a devastating disease that commonly results in early onset dementia, yet its rarity and heterogeneity limit large-scale research and clinical trials. +1 more finding

    Scored 43 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  4. 2026-09-21

    Physiological variability in key Alzheimer's biomarkers in amyloid-positive clinical trial cohorts and the mechanistic basis of biomarker ratios

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

    Key finding: While normalizing biomarker values by A{beta}40 or A{beta}42 reduced physiological variability for some biomarkers, the effects of the normalization were compartment-, and cohort-dependent. +4 more findings

    Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  5. 2026-09-21

    Phosphorylated tau 217 in young adults with Down syndrome and Down syndrome regression disorder

    ✓ Peer-reviewed Down syndrome and Alzheimer's Communications Medicine

    Key finding: These findings provide no evidence of a group-level Alzheimer-related p-tau217 elevation in young people with DSRD and support DSRD as a condition distinct from Alzheimer’s disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2026-09-21

    A Harmonized Visual Reading Framework for Tau PET Staging in Alzheimer Disease

    ✓ Peer-reviewed Brain scans and imaging JAMA Neurology

    Key finding: Of 822 individuals enrolled in the HEAD study, 681 participants spanning cognitively unimpaired to dementia were included. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2026-09-21

    T1 mapping in Alzheimer’s disease: a quantitative MRI study with amyloid-PET correlation

    ✓ Peer-reviewed Biomarkers European Radiology Experimental

    Key finding: Thirty-three AD subjects, aged 69.3 ± 8.2 years (mean ± standard deviation), 18 females, and 22 HCs aged 70.5 ± 13.3 years, 15 females, were evaluated. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2026-09-20

    Underlying histopathology features of white matter hyperintensities in vascular and neurodegenerative disorders: a systematic review

    ⚠ Preprint — not yet peer-reviewed Lewy body dementia Research Square

    Key finding: As a result, histopathological data on WMHs from gold-standard studies remain limited relative to their clinical prevalence. +1 more finding

    Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  9. 2026-09-20

    Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases

    ⚠ Preprint — not yet peer-reviewed Lewy body dementia bioRxiv

    Key finding: These findings reveal a previously unrecognized role for TDP-43 in repressing cryptic circRNA formation and establish these circRNAs as stable molecular signatures of TDP-43 dysfunction.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  10. 2026-09-20

    A Multimodal Mathematical and Computational Framework for Personalized Medication-Adherence and Cognitive-Risk Modeling in Alzheimer's Disease

    ⚠ Preprint — not yet peer-reviewed Digital health tools Research Square

    Key finding: This working paper proposes a seven-layer mathematical and computational research framework that (i) formalizes multimodal behavioral data — medication-taking events, response latency, activity, and cognitive-task performance — as a time-indexed state vector; (ii) applies probabilistic and statistical inference to identify features associated with adherence difficulty; (iii) compares logistic, ensemble, neural, and temporal machine-learning model families under a common, pre-registered evaluation protocol; and (iv) tests whether personalized, participant-conditioned models outperform population-level baselines. +1 more finding

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  11. 2026-09-20

    MedBackdoorGuard: Detecting and Mitigating Backdoor Attacks in Deep Learning Models for MRI-Based Alzheimer's Disease and Mild Cognitive Impairment Diagnosis

    ⚠ Preprint — not yet peer-reviewed Digital health tools Preprints.org

    Key finding: Compared with the strongest defense baseline, attack success rate falls by 15.1 percentage points and clean accuracy rises by 1.7 percentage points.

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  12. 2026-09-20

    Rab11-exosome biogenesis regulators mediate Aβ-induced intercellular propagation of endolysosomal trafficking defects and neurodegeneration

    ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE bioRxiv

    Key finding: Recent studies in non-neuronal Drosophila secondary cells (SCs) have revealed that Aβ interferes with APP-regulated protein aggregation events, which package signalling molecules into insoluble dense-core granules (DCGs) during normal regulated secretion, inducing endolysosomal defects that are transferred to other cells. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  13. 2026-09-20

    A lifespan single-cell atlas of the human developing hippocampus benchmarks familial Alzheimer’s disease brain organoids

    ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE bioRxiv

    Key finding: Here, we constructed the Human Developing Hippocampus Atlas (HuDeHA), an integrated single-cell reference comprising 658,059 cells spanning post-conceptional week 3 to 15.3 years, and used it to benchmark iPSC-derived brain organoids carrying PSEN1 E280A which is associated with fAD in a large Colombian population. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  14. 2026-09-20

    A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics bioRxiv

    Key finding: This program, not the DAM signature, marks phagocytically competent microglia; its loss is associated with proteostatic overload and mitochondrial dysfunction.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  15. 2026-09-20

    TDP-43 dysfunction induces cryptic circular RNAs in ALS/FTD

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: Here, we identified TDP-43 as a regulator of circular RNA (circRNA) biogenesis in multiple human neuronal cell models, and showed that its dysfunction induces the de novo formation of cryptic circular RNAs (c-circRNAs). +3 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  16. 2026-09-20

    Associations of menopause hormone therapy with late-life cognition and brain health vary by formulation and APOEε4 presence

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

    Key finding: Implications of menopause hormone therapy (MHT) for cognitive aging remain unclear despite decades of research. +2 more findings

    Scored 30 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  17. 2026-09-20

    Myo-inositol as a spectroscopic marker of neuroinflammation in frontotemporal lobar degeneration

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

    Key finding: We focus on neuroinflammation in disorders associated with frontotemporal lobar degeneration (FTLD). +4 more findings

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  18. 2026-09-20

    Varenicline as a Repurposable Drug Candidate for ADRD Prevention

    ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv (preprint)

    Key finding: Varenicline use was associated with a reduced risk of ADRD (HR 0.516, 95% CI: 0.353-0.754) and the composite outcome ADRD or death (HR 0.657, 95% CI: 0.501-0.861). +4 more findings

    Scored 36 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  19. 2026-09-20

    Genetically Predicted Blood DNA Methylation Reveals Putative Regulatory Signals Associated with ALS Risk

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

    Key finding: At a nominal threshold of p < 0.05, 3,741 CpGs were associated with ALS risk using ARIES models and 13,127 using Understanding Society models. +4 more findings

    Scored 20 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  20. 2026-09-20

    A longitudinal study of age-related traits and cognitive function: The Collaborative Amish Aging and Memory Project (CAAMP)

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

    Key finding: The remaining 1,050 did not have detailed cognitive evaluations at their enrollment. +4 more findings

    Scored 41 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  21. 2026-09-20

    Heritability and rare variant contributions to Alzheimer disease in the Midwestern Amish

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

    Key finding: ResultsHeritability estimates suggested that common variants explain much of genetic risk among APOE-{varepsilon}4 carriers, while unexplained heritability remains in non-carriers in the Amish. +1 more finding

    Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  22. 2026-09-19

    Network-based gene prioritization using hybrid scoring for complex disease module discovery

    ✓ Peer-reviewed Risk genes beyond APOE Scientific Reports

    Key finding: In each case the framework recovered known disease genes and identified biologically coherent, disease-specific modules: in AD, 17 stable high-confidence genes and modules enriched in lipid and cholesterol metabolism and amyloid precursor protein processing; in PD, 17 stable genes and modules associated with mitophagy, ubiquitin-proteasome signaling, and mitochondrial dysfunction; in RA, 20 stable genes and modules enriched in antigen presentation and JAK-STAT cytokine signaling. +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2026-09-18

    Hippocampal surface analysis using discrete Ricci flow and Riemannian metrics for the diagnosis of Alzheimer's disease

    ⚠ Preprint — not yet peer-reviewed Getting a diagnosis Research Square

    Key finding: Experimental results on ADNI dataset show that AIRM achieves the best performance with 96\% accuracy, which outperforms other metrics evaluated. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  24. 2026-09-18

    Population-scale burden analysis of rare damaging coding variants identifies novel risk genes for Alzheimer's disease and related dementias and Parkinson's disease and related disorders

    ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

    Key finding: Our results demonstrate the value of population-scale sequencing to identify rare coding risk genes for neurodegenerative diseases.

    Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  25. 2026-09-17

    Changing Landscape of Alzheimer’s Disease Mortality in the United States (1979– 2023): A CDC WONDER Analysis of Epidemiological Shifts, Disparities and ARIMA-Based Projections to 2050

    ⚠ Preprint — not yet peer-reviewed How common it is Research Square

    Key finding: Between 1979 and 2023, AD caused 2,430,795 deaths in U.S. adults. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →