Newest studies

Advancing Theranostics in Alzheimer Disease: FDA Approval of Amyloid- PET Drugs for Selection of Patients for Amyloid-ߖDirected Therapies and Other Labeling Updates

31/100 ✓ Peer-reviewed Biomarkers Journal of Nuclear Medicine

Key finding: Theranostics—the use of diagnostic and therapeutic drugs that target the same molecular marker of disease—extends beyond the paradigm of radiopharmaceutical drug pairs used in oncologic settings (e.g., somatostatin receptor subtype 2 and prostate-specific membrane antigen theranostics) to other

• Treatments

Full summary, score breakdown and related studies → Original source

ASHP Statement on the Pharmacist’s Role in Substance Use Disorder Prevention, Treatment, and Recovery

41/100 ✓ Peer-reviewed Health systems and care delivery American Journal of Health-System Pharmacy

Key finding: In both adolescents and adults with SUD, approximately 95% did not perceive a need for treatment.1 Although drug-related overdose deaths are declining, over 98,000 American deaths occurred in 2024.2 The vast majority of drug overdose deaths involve unregulated opioids, and in 2022 roughly 6.1 million people had an opioid use disorder (OUD) in the prior year.1 Costs related to the consequences of substance use the United States were nearly $1.5 trillion in 2020, up 37% from $1.07 trillion in 2017.3,4 Unhealthy substance use and untreated SUD may increase the risk of significant comorbid chronic health conditions, death from overdose, or suicide. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks

70/100 ✓ Peer-reviewed Biomarkers Nature medicine

Key finding: The estimated age at plasma %p-tau217 positivity was associated with the age at onset of AD symptoms (adjusted R 2 of 0.337-0.612) with a median absolute error of 3.0-3.7 years. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Advance Care Planning, Race, and Age

40/100 ✓ Peer-reviewed End-of-life care American Journal of Medical Quality

Key finding: The analysis included 580 hospitalizations for 552 eligible patients. +4 more findings

• End-of-Life Care
• Health Equity

Full summary, score breakdown and related studies → Original source

Plasma Proteomic Analysis of APOE ε4 Homozygotes Identifies Preclinical Alzheimer’s Disease Alterations Potentially Modulated by Semaglutide

16/100 ⚠ Preprint — not yet peer-reviewed Drug development medRxiv

Key finding: Semaglutide—a GLP-1 receptor agonist—demonstrated reversal effects on metabolic and synaptic pathway alterations in ε4 homozygotes at preclinical and clinical AD stages.

• Treatments
• Genetics
• Early Stage

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Association of infections and autoimmune conditions with cognition: a study using self-reported conditions and identifying a novel plasma biomarker

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: These conditions were then compared with the diagnosis and cognitive performances of each participant. +2 more findings

• Biomarkers

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Dermatological Problems and Treatment in Long-Term/Nursing-Home Care

27/100 ✓ Peer-reviewed Health systems and care delivery Geriatric Dermatologic Therapy

Key finding: Although healthcare professionals and nursing staff generally focus on pressure injuries and incontinence-related dermatitis, infectious diseases, and epidemics can also be significant problems in nursing homes.

• Care Services

Full summary, score breakdown and related studies → Original source

Convolutional Neural Network Achieves 97.67 Percent Accuracy for Alzheimer MRI Classification

32/100 ✓ Peer-reviewed Brain scans and imaging Academia Open

Key finding: Using approximately 5,000 ADNI MRI images, the model achieved 97.67% accuracy, 97.73% precision, 97.67% recall, and 97.65% F1-score, with AUC values near 1.00. +4 more findings

• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Dementia and hearing loss: from risk to mechanisms and management

42/100 ✓ Peer-reviewed Prevention and risk Frontiers in Dementia

Key finding: Hearing loss in midlife is an important and potentially modifiable risk factor for the development of dementia. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Multiple-testing corrections in case-control studies using identity-by-descent segments

40/100 ✓ Peer-reviewed Genetics The American Journal of Human Genetics

Key finding: Whole-genome simulations indicate that our method conservatively controls the FWER. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Systemic inflammation, delirium and clinical progression in mild-moderate Alzheimer disease

44/100 ✓ Peer-reviewed Biomarkers EBioMedicine

Key finding: Systemic inflammatory biomarkers were primarily associated with age/socio-demographic characteristics, remained strikingly stable over time, and were not associated with AD progression. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Improving Access to Cognitive Interventions for People With Dementia in Australian Community‐Based Settings

39/100 ✓ Peer-reviewed Prevention trials Australasian Journal on Ageing

Key finding: Current evidence indicates cognitive interventions have varying benefits across different outcomes, including cognitive function, social engagement, everyday functioning, quality of life and goal attainment. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN

50/100 ✓ Peer-reviewed Risk genes beyond APOE npj Dementia

Key finding: The Dominantly Inherited Alzheimer Network Observational Study (DIAN Obs) is a longitudinal, global cohort study investigating brain aging and autosomal dominant Alzheimer’s disease (ADAD), a rare monogenic form of Alzheimer’s disease (AD). +4 more findings

• Genetics
• Brain Scans

Full summary, score breakdown and related studies → Original source

Lipidomic signatures reveal biomarkers of mild cognitive impairment

45/100 ✓ Peer-reviewed Mild cognitive impairment Translational Psychiatry

Key finding: Compared with controls, MCI patients exhibited increased oxidized triacylglycerols (oxTGs) in saliva, reduced cholesteryl linoleate (CE 18:2) in plasma, and decreased fatty acid esters of hydroxy fatty acids (FAHFAs) in feces.

• Early Stage
• Biomarkers

Full summary, score breakdown and related studies → Original source

Reasons for and against presymptomatic genetic testing in frontotemporal dementia: a qualitative study

44/100 ✓ Peer-reviewed Lewy body dementia Human Genetics

Key finding: Reasons against presymptomatic genetic testing were fearing psychological impact, fearing effects on employment, insurability or mortgage, maintaining hope, and no immediate relevance for life planning, partly due to uncertainty surrounding age of onset. +4 more findings

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders

59/100 ✓ Peer-reviewed Lewy body dementia Nature Medicine

Key finding: CSF DDC levels were significantly higher in DLB and PD (up to 2.5-fold versus controls; 1.9-fold versus AD), showing area under the curve values > 0.9 for differential diagnosis. +2 more findings

• Other Dementias
• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

An Artificial Intelligence-Driven Multimorbidity Framework Reveals a Shared Metabolic and Immune Core Across Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

38/100 ✓ Peer-reviewed Digital health tools Biomedicines

Key finding: Across AD, ALS, and FTD, a convergent multimorbidity architecture centered on a shared metabolic and immune core was identified, accompanied by prominent neurobehavioral processes and intermediate systems including gastrointestinal, endocrine, hematological, hepatic, and sensory pathways. +4 more findings

• Digital Tools
• Other Dementias

Full summary, score breakdown and related studies → Original source

Access to healthcare services and adherence to treatments for people with dementia among ethnic minority groups: a scoping review

35/100 ✓ Peer-reviewed Disparities Frontiers in Dementia

Key finding: People with dementia from ethnic minority groups report lower quality care received. +4 more findings

• Health Equity
• Treatments

Full summary, score breakdown and related studies → Original source

Progression-Aware and Explainable CNN–Transformer Framework for Multiclass Alzheimer’s Disease Staging Using MRI

35/100 ✓ Peer-reviewed Brain scans and imaging Diagnostics

Key finding: The experimental findings on a multiclass MRI dataset of Alzheimer disease demonstrate consistent and high performance across cross-validation folds (mean F1-score (0.991 ± 0.003) and AUROC (0.9998 ± 0.0002)), without losing transparency and progress awareness. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Time From Initial Community‐Based Dementia Consultation to Confirmed Diagnosis: A Retrospective Analysis

34/100 ✓ Peer-reviewed Treatments Psychogeriatrics

Key finding: A total of 739 patients were included: 504 with AD and 235 with non-AD dementias. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Incidence of dementia after a recent cancer diagnosis among people with HIV

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: Dementia risk may be increased among people with HIV with certain cancers, including AIDS-defining cancers.

• Risk Factors
• Diagnosis

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Assessing the risk of early-onset dementia within 5 years of cancer diagnosis

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: EOD incidence peaked at 4-5% among beneficiaries with and without cancer. +1 more finding

• Diagnosis

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Refining Alzheimer's disease biological diagnosis with plasma biomarkers: Resolving p-tau217 "gray zone" with p-tau181 integration

61/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Plasma p-tau217 demonstrated the strongest discrimination of Core1 positivity (area under the curve [AUC] = 0.95) and showed the steepest increase with disease progression. +3 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Genetic risk in Alzheimer's disease

45/100 ✓ Peer-reviewed Genetics NPJ systems biology and applications

Key finding: Alzheimer's disease (AD) has a strong genetic predisposition. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Bringing up the end of life and euthanasia. A mixed method study on consultations with people with dementia and their families in the hospital setting

39/100 ✓ Peer-reviewed End-of-life care Palliative Medicine

Key finding: End-of-life topics were discussed in 36% of consultations (in regional hospitals, 53%; in academic settings, 27%), and predominantly during diagnostic consultations (54%). +4 more findings

• End-of-Life Care
• Caregiving
• Care Services

Full summary, score breakdown and related studies → Original source