Newest studies

Effectiveness of a Socially Implemented Cognitive Decline Prevention Program: A Retrospective Observational Study

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery medRxiv

Key finding: The multifactorial interventions implemented in community settings showed no effect on dementia onset or health outcomes. +4 more findings

• Prevention

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Imaging-genetics-based dementia risk prediction using deep survival neural networks in the Rotterdam Study

43/100 ✓ Peer-reviewed Long-term cohort studies Scientific Reports

Key finding: Our approach indicates that imaging and genetic data can be feasibly integrated for dementia risk prediction, with informative extraction, reliable explanations and potential predictive gains.

• Brain Scans
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Parkinson’s disease dementia and hearing impairment, are they related? A UK biobank pilot analysis

58/100 ✓ Peer-reviewed Long-term cohort studies Experimental Brain Research

Key finding: An exploratory analysis, in which speech-reception-thresholds were categorised according to UK Biobank norms, showed that ‘insufficient’ (p = .024), but not ‘poor’ (p = .236) hearing increased PDD risk. +2 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Trajectories of plasma and CSF MTBR-tau243 and phosphorylated-tau species across the Alzheimer’s disease continuum

53/100 ✓ Peer-reviewed Biomarkers Nature Communications

Key finding: Bootstrapped LOESS models showed that %p-tau217 changes earliest, increasing just before Aβ-PET positivity. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Application of Plasma Neuron-Derived Exosome-Based Multimodal Biomarkers in the Early Diagnosis of Alzheimer's Disease

16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers Research Square

Key finding: Alzheimer disease (AD) pathology begins 15–20 years before clinical symptoms, necessitating non - invasive biomarkers for early diagnosis. +3 more findings

• Biomarkers
• Diagnosis
• Brain Biology

Scored 23 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

The role of frailty and comorbidities in severe infections and the risk of dementia: a prospective, multicohort, observational study

67/100 ✓ Peer-reviewed How common it is The lancet. Healthy longevity

Key finding: Frailty, comorbidities, and other age-related diseases were associated with a higher risk of dementia but did not account for the elevated dementia risk observed after severe infections. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology

43/100 ✓ Peer-reviewed Disease mechanisms Science Translational Medicine

Key finding: Neurons accumulated seeding-competent and hyperphosphorylated tau in tangle-like structures. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

From clinical judgment to biology: a clinician's opinion on the use of blood-based biomarkers in Alzheimer's disease

35/100 ✓ Peer-reviewed Tau biomarkers Frontiers in Neurology

Key finding: This position is justified by the fact that not all individuals with positive biomarkers will progress to symptomatic disease, as well as by the considerable variability in biomarker results depending on the type of marker and the laboratory performing the analysis (3).Both frameworks agree that biomarkers enhance diagnostic certainty but differ in the degree of reliance placed upon them. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Plasma biomarkers of neurodegeneration and neuroinflammation in intracranial atherosclerotic disease

63/100 ✓ Peer-reviewed Biomarkers Brain communications

Key finding: In multivariable analyses, none of the plasma biomarkers were significantly associated with cognitive impairment. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma pTau 217/β-amyloid 1-42 ratio for enhanced accuracy and reduced uncertainty in detecting amyloid pathology

61/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology

Key finding: To improve clinical utility, a dual threshold approach was applied to maximize predictive values and positive likelihood ratios while minimizing the proportion of indeterminate results. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

KCTD20 Suppression as a Potential Therapeutic Strategy against Neurodegenerative Tauopathies

25/100 ✓ Peer-reviewed Disease mechanisms Current Neuroscience

Key finding: The accumulation of tau proteins in the brain contributes to the therapeutic challenges faced by patients with Alzheimer’s disease, frontotemporal dementia, and other neurodegenerative disorders. +3 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Modelling synaptic dysfunction in childhood dementia using human iPSC-derived cortical networks

44/100 ✓ Peer-reviewed Disease mechanisms Nature Communications

Key finding: Here authors show in a human stem cell–derived model, neural cultures from children with MPSIIIA exhibit hyperactive excitatory synapses associated with excitation–inhibition imbalance, altered network dynamics, and broad dysregulation of genes involved in synaptic homeostasis.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Schizophrenia and dementia across the lifespan: epidemiological links, cognitive trajectories, and the pathophysiological interplay

47/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Neurology

Key finding: Epidemiological studies consistently indicate a two- to threefold increased risk of dementia among individuals with schizophrenia, although estimates vary due to diagnostic and ascertainment biases. +4 more findings

• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source

Neurocapsule : Alzheimer Risk Predictor and Digital Memory Vault

41/100 ✓ Peer-reviewed Brain scans and imaging Zenodo (CERN European Organization for Nuclear Research)

Key finding: Alzheimer's disease is a progressive neurodegenerative disorder that significantly impacts memory, cognition, and daily functioning. +1 more finding

• Digital Tools

Full summary, score breakdown and related studies → Original source

Neurocapsule : Alzheimer Risk Predictor and Digital Memory Vault

28/100 ✓ Peer-reviewed Brain scans and imaging Zenodo (CERN European Organization for Nuclear Research)

Key finding: Alzheimer's disease is a progressive neurodegenerative disorder that significantly impacts memory, cognition, and daily functioning. +1 more finding

• Digital Tools

Full summary, score breakdown and related studies → Original source

AI-driven magnetoencephalography biomarkers in dementia risk prediction: current evidence, challenges and future perspectives

39/100 ✓ Peer-reviewed Getting a diagnosis Frontiers in Dementia

Key finding: Fourteen studies met eligibility criteria, covering populations from healthy controls to individuals with subjective cognitive decline, MCI, AD, and other dementias. +4 more findings

• Digital Tools
• Biomarkers

Full summary, score breakdown and related studies → Original source

Systematic Review of Population-Based Studies of Prevalence and Incidence of Aging-Associated Neurodegenerative Diseases in Russia

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: The prevalence of dementia and Parkinson’s disease in Russia varies widely depending on diagnostic method, age group, and study design. +1 more finding

• Diagnosis
• Risk Factors

Scored 56 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease

57/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer's research & therapy

Key finding: Collectively, plasma biomarker findings in the low p-tau217 subgroup were more robust than in the mITT population. +4 more findings

• Clinical Trials
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Predictors of Hospital Admission Following Emergency Department Presentation for Falls Among Older Adults: A Retrospective Analysis

49/100 ✓ Peer-reviewed Clinical safety Australasian Journal on Ageing

Key finding: Of 574 older adults, 187 (33%) were admitted. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Alterations of gut microbiota in Down syndrome and their association with Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

Key finding: Structured Abstract INTRODUCTION Adults with Down syndrome (DS) have a higher risk of developing Alzheimer’s disease (AD). +2 more findings

• Down Syndrome
• Biomarkers

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's disease treated with Lecanemab: A real-world study

70/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: The mean age was 74.2 ± 7.9 years, and 89 (74%) were female. +4 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Beneficial Effects of Olive Oil and the Mediterranean Diet on Alzheimer’s Disease and Vascular Dementia: A Review

36/100 ✓ Peer-reviewed Prevention trials Medicina

Key finding: This diet has been shown to improve cognitive function in patients with mild cognitive impairment, Alzheimer’s disease, vascular cognitive impairment, and vascular dementia. +3 more findings

• Lifestyle
• Clinical Trials
• Other Dementias

Full summary, score breakdown and related studies → Original source

Dietary silver nanoparticle supplementation induces Alzheimer-like lesions through Bifidobacterium deficiency-dominated gut microbiota dysbiosis and neuroinflammation

35/100 ✓ Peer-reviewed Inflammation and the immune system npj Science of Food

Key finding: Dietary supplement silver nanoparticles have recently drawn attention following reports of hazards associated with long-term use. +1 more finding

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Randomized, double-blind study of zervimesine in mild to moderate Alzheimer's disease

86/100 ✓ Peer-reviewed Clinical trials Journal of Alzheimer's disease : JAD

Key finding: At Day 182, the ADAS-Cog 11 increased from baseline (indicating a decline in cognitive function) with the LS mean (SE) change of 2.69 (0.81) points in the placebo group versus 1.66 (0.60) points in the pooled zervimesine group [δ = -1.03 (-3.01, 0.96), p = 0.310]. +2 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Sex differences for clinical presentations and co-pathologies in four-repeat tauopathies

42/100 ✓ Peer-reviewed Disease mechanisms Biology of Sex Differences

Key finding: Most common clinical diagnosis was PSP (41%) for PSP; unspecified FTD (36%) for CBD; AD for AGD (57%) and Other-4R groups (48%), without sex differences. +4 more findings

Full summary, score breakdown and related studies → Original source