Newest studies

APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model

38/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer s & Dementia

Key finding: APP‐mediated signaling plays a key role in regulating sleep, maintaining BBB integrity, and preserving memory in AD.

• Brain Biology
• Lifestyle
• Digital Tools

Full summary, score breakdown and related studies → Original source

Social disadvantage outweighs knowledge in dementia risk

50/100 ✓ Peer-reviewed Digital health tools Alzheimer s & Dementia

Key finding: Lower SES and education were the strongest predictors of increased behavioral risk. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Generative artificial intelligence in dementia care: a scoping review protocol on nursing roles, experiences and ethical perspectives

51/100 ✓ Peer-reviewed Digital health tools BMJ Open

Key finding: Critical appraisal will not be undertaken, as it is optional in scoping reviews and is not aligned with the primary mapping objectives of this review. +4 more findings

• Digital Tools

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Investigating the Utility of Explainable Artificial Intelligence for Neuroimaging‐Based Dementia Diagnosis and Prognosis

41/100 ✓ Peer-reviewed Digital health tools Human Brain Mapping

Key finding: Models achieved balanced accuracies of 81% and 67% for diagnosis and prognosis. +4 more findings

• Digital Tools
• Brain Scans
• Diagnosis

Full summary, score breakdown and related studies → Original source

Health of Bi+ Dementia Caregivers: Moderation Effects of Minority and Caregiving Stress

47/100 ✓ Peer-reviewed Disparities American Journal of Alzheimer s Disease & Other Dementias®

Key finding: Bi+ caregivers reported significantly higher minority stress and lower family quality of life but better health than g/l caregivers. +2 more findings

• Health Equity
• Caregiving

Full summary, score breakdown and related studies → Original source

Comparing phenotypic features between Parkinson’s disease dementia and dementia with Lewy bodies

39/100 ✓ Peer-reviewed Getting a diagnosis Journal of Neurology

Key finding: Patients with PDD showed a more severe phenotype than those with DLB, with higher scores in motor severity, hallucinations, delusions, somnolence, and urinary dysfunction (all p≤0.01). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Sex differences in Alzheimer's disease plasma biomarker levels and clinical utility

41/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia

Key finding: Among CU participants, men had lower Aβ42 and GFAP, and higher p-tau217/Aβ42. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Plasma p‐tau217 predicts PET‐based pathological staging for precision Alzheimer disease assessment

46/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia

Key finding: Plasma p-tau217-based biomarkers showed excellent detecting performance for early amyloid (Thal I-II; area under the curve values > 0.96) and intermediate tau (Braak III-IV; area under the curve values > 0.92). +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Evaluating the effects of the World Health Organisation's online intervention 'iSupport lite' to reduce burden in multilingual dementia carers: results from the Australian Draw-Care randomised clinical trial

59/100 ✓ Peer-reviewed Caregiving Age and ageing

Key finding: One hundred sixteen participants consented and 93 (46 waitlist control, 47 intervention) were included in the analyses. +2 more findings

• Clinical Trials
• Caregiving
• Digital Tools

Full summary, score breakdown and related studies → Original source

Preventive and Need-Driven Use of Dental Services among Community-Dwelling Older People with Long-Term Care Needs

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery medRxiv

Key finding: This study examined patterns of preventive and need-driven dental service use among home-dwelling older adults with LTC needs in Japan and identified the caregiving, functional, and socioeconomic factors associated with these patterns. +3 more findings

• Care Services

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Lifetime cost-effectiveness of lecanemab for early Alzheimer's disease

52/100 ✓ Peer-reviewed Costs and economics Frontiers in public health

Key finding: The incremental cost of the lecanemab group compared to the aducanumab group was $30,018.97, with an increase in quality-adjusted life-years (QALYs) of 0.25, resulting in an ICER of $121,678.49 per QALY gained. +4 more findings

• Policy
• Treatments

Full summary, score breakdown and related studies → Original source

Traumatic Brain Injury and All-Cause and Dementia-Related Mortality in the Framingham Heart Study

60/100 ✓ Peer-reviewed Long-term cohort studies JAMA Network Open

Key finding: This study included 10 333 FHS +4 more findings

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Crispr/cas9 como alternativa terapêutica para pacientes com doença de Alzheimer: uma revisão integrativa

28/100 ✓ Peer-reviewed Risk genes beyond APOE Revista Neurociências

Key finding: Además, la corrección de mutaciones como PSEN1 M146L demostró eficacia en la reducción de beta-amiloide y la restauración de funciones celulares. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

GABAergic activity and gamma oscillations in Alzheimer’s disease and mild cognitive impairment: Neuropathology and therapeutic neuromodulatory insights from animal and human studies

49/100 ✓ Peer-reviewed Mild cognitive impairment Brain Network Disorders

Key finding: Disruptions in GABAergic activity and alterations in gamma oscillations are key pathological features of AD associated with amyloid-beta (Aβ) plaques. +2 more findings

• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

A new paradigm for stratified cognitive assessment: fusing serum Raman spectroscopy and ensemble learning

40/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer s Research & Therapy

Key finding: We developed a serum Raman spectroscopy-based ensemble learning approach for graded cognitive screening. +4 more findings

• Diagnosis

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Causality between Alzheimer disease and delirium: A two-sample Mendelian randomization study and gene colocalization analyses

38/100 ✓ Peer-reviewed Genetics Medicine

Key finding: The preliminary findings revealed a causal link between AD (21,982 cases and 41,944 controls) and delirium (comprising 1269 cases and 209,487 controls). +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Early Behavioral and Cognitive Changes in Patients With Pathologically Confirmed Alzheimer Disease, Lewy Body Dementia, and Mixed Dementia

55/100 ✓ Peer-reviewed Genetics Neurology Open Access

Key finding: The study included 1,028 participants (mean age at baseline 76.4 years; 47.6% female): 521 with ADP, 96 with LBP, and 411 with mixed AD-LBP. +4 more findings

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Dynamic trends, spatial clustering, and multi-model projections of the global burden of Alzheimer’s disease and other dementias: an analysis of GBD 1990–2021 data to 2050

40/100 ✓ Peer-reviewed Risk factors Frontiers in Aging Neuroscience

Key finding: From 1990 to 2021, global ADOD burden increased markedly in absolute terms. +4 more findings

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Clonal expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA

53/100 ✓ Peer-reviewed Laboratory science Nature Communications

Key finding: Here we show, through multi-omic profiling of peripheral blood from three ARIA+ patients and matched controls, that ARIA is associated with coordinated reprogramming of CD8 + T cells. +2 more findings

• Side Effects
• Treatments

Full summary, score breakdown and related studies → Original source

Proteomic biomarkers of cognitive function, APOE ε4 status, and dementia in Generation Scotland

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: We observed associations between three cognitive tests (digit symbol, vocabulary and verbal fluency) and a mass spectrometry signal that mapped to selenoprotein P (absolute β range = 0.02 – 0.03, posterior inclusion probability ≥ 0.95). +2 more findings

• Biomarkers
• Genetics

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Elucidation of Molecular Mechanisms of Lipid-Altered Cytotoxicity of TDP-43 Fibrils

38/100 ✓ Peer-reviewed Brain tissue and pathology ACS Chemical Neuroscience

Key finding: We found that lipid bilayers composed of anionic phosphatidylserine and cardiolipin accelerated TDP-43 aggregation. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Molecular features of human pathological tau distinguish tauopathy-associated dementias

52/100 ✓ Peer-reviewed Digital health tools Cell

Key finding: In Alzheimer's disease (AD), pathological tau protein shows a progressive accumulation of post-translational modifications (PTMs), reflecting disease severity, progression, and prion-like activity. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Validation of the Danish version of the Carer Experience Scale in family caregivers of people with dementia

39/100 ✓ Peer-reviewed Caregiving Health and Quality of Life Outcomes

Key finding: The CES effectively distinguished between different levels of caregiver strain. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Neuropsychiatric Symptoms and Caregiver Burden in Dementia: A Longitudinal Dyadic Cohort Study

44/100 ✓ Peer-reviewed Caregiving Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Key finding: At baseline, nearly one-third of caregivers reported moderate-to-severe burden (mean ZBI 31.4 ± 15.4), a prevalence that persisted at 6 months. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Postmortem Associations Between Alzheimer Disease Pathology and Plasma pTau217, GFAP, and NfL in AD and AD-Related Dementias

66/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: One hundred eighty-seven participants with brain autopsy (NPDx1: AD n = 85; other n = 102; mean age: 74.3 years, 38.5% female; interval blood collection-death [mean ± SD]: 2.8 ± 1.6 years) and 67 NC without brain autopsy (mean age: 66.5 years, 71.6% female) were included. pTau217, but not GFAP, levels increased stepwise with increasing Thal phases (β = 0.61; 95% CI [0.24-0.97] to β = 0.91 [0.55-1.27]) and Braak stages (β = 0.59; [0.16-1.01] to β = 0.74 [0.33-1.15]). +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source