Newest studies

ENHANCED ALZHEIMER DISEASE DIAGNOSIS THROUGH DEEP LEARNING-BASED MRI SEGMENTATION AND CLASSIFICATION

26/100 ✓ Peer-reviewed Brain scans and imaging RCHUB JOURNAL OF COMPUTATIONAL INTELLIGENCE SCIENCE AND ENGINEERING (JCISE)

Key finding: MRI has become an effective modality for analyzing the brain structure, which offers a detailed insights into the pathological regions that is associated with the AD. +1 more finding

• Brain Scans
• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Amyloid probability in Alzheimer disease from plasma, cerebrospinal fluid, and amyloid imaging

36/100 ✓ Peer-reviewed Brain scans and imaging npj Dementia

Key finding: Blood-based biomarkers are increasingly used to triage patients for amyloid confirmation, yet performance is often reported versus a single comparator despite discordance between amyloid PET and CSF.

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Towards an Equitable Approach to Multilingual Language Assessment in Dementia Care

33/100 ✓ Peer-reviewed Getting a diagnosis Topics in Language Disorders

Key finding: Health disparities in dementia care are amplified among aging multilingual communities relative to their monolingual English-speaking counterparts, as social determinants of health and significant gaps in culturally responsive practice can contribute to misdiagnosis, underdiagnosis, and delays in intervention. +1 more finding

• Diagnosis

Full summary, score breakdown and related studies → Original source

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk

37/100 ✓ Peer-reviewed Genetics DOAJ (DOAJ: Directory of Open Access Journals)

Key finding: We show that CD33M ectodomain dimerizes, enabling binding of large multi-sialylated molecules.

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Recent breakthroughs in blood-based biomarkers of Alzheimer disease: opportunities and challenges in older adults

36/100 ✓ Peer-reviewed Biomarkers Age and Ageing

Key finding: Across multiple analytical platforms, plasma p-tau217 has demonstrated consistently strong diagnostic performance for the detection of amyloid pathology. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Loneliness Moderates the Association between Neighborhood Disadvantage and Cognitive Function Among Older Adults

41/100 ✓ Peer-reviewed Risk factors Delaware Journal of Public Health

Key finding: Loneliness moderated the relationship between national ADI scores and short-term visuospatial memory. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

[Consistency evaluation of the domestic Lifotronic platform and foreign luminescence platforms in detecting core cerebrospinal fluid biomarkers in Chinese Alzheimer disease patients]

43/100 ✓ Peer-reviewed Tau biomarkers Zhonghua yi xue za zhi

Key finding: CSF samples were retrospectively collected from 253 subjects recruited at Peking Union Medical College Hospital, Xuanwu Hospital Capital Medical University, and Beijing Tiantan Hospital between July 2013 and September 2019. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy

52/100 ✓ Peer-reviewed Tau biomarkers JAMA network open

Key finding: In vivo biomarkers for detecting neuropathologies from repetitive head impacts (RHI), including chronic traumatic encephalopathy (CTE), are needed. +3 more findings

• Biomarkers
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Early Alzheimer´s disease blood biomarkers are associated with a higher risk for postoperative long-term cognitive decline: Insights from the FINDERI study

49/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The study aim is to investigate whether blood biomarkers (BBMs) of Alzheimer's disease (AD) pathology are associated with postoperative cognitive dysfunction (POCD) after cardiac surgery. +3 more findings

• Biomarkers
• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source

Lecanemab in symptomatic PSEN1 p.Met233Val early-onset Alzheimer's disease: Neuroimaging safety, regional amyloid-PET dynamics, and longitudinal plasma biomarkers

46/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: No amyloid-related imaging abnormalities occurred. +3 more findings

• Biomarkers
• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

The tau biomarker cascade is condensed in Down syndrome compared with sporadic Alzheimer's disease

56/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain : a journal of neurology

Key finding: Individuals with DS had a significantly higher lifetime risk of beta-amyloid plaque onset. +1 more finding

• Biomarkers
• Down Syndrome
• Treatments

Full summary, score breakdown and related studies → Original source

Plasma eMTBR-tau243 and %p-tau217 for Biological Staging of Alzheimer Disease

68/100 ✓ Peer-reviewed Biomarkers JAMA Neurology

Key finding: The BioFINDER-2 main cohort included 872 participants, with an additional 156 participants in the Knight ADRC cohort for independent validation. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

APOE-ε4 carriership and dementia risk over 10 years among Asian American and White older adults

55/100 ✓ Peer-reviewed Genetics Alzheimer's & Dementia

Key finding: Despite differences in prevalence of APOE-ε4, its association with dementia risk was similar across Chinese, Japanese, Filipino, and non-Latino White participants. +1 more finding

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Genetic Risk for Alzheimer Disease, Midlife Hypertension, and Dementia: The ARIC Neurocognitive Study

58/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Genetic risk for AD does not modify the association between hypertension and dementia. +3 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Functional–behavioral patterns associated with care-related risk in hospitalized patients with Alzheimer’s disease: a real-world clustering analysis

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety Research Square

Key finding: Functional–behavioral subtypes can be identified in hospitalized AD patients, supporting multidimensional risk stratification and individualized care planning. +1 more finding

• Care Services

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

How and why adult day programs influence admissions to long-term care homes for persons living with dementia: A program theory based on a realist review

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery Research Square

Key finding: Contexts and mechanisms associated with attendees’ and caregivers’ social determinants of health, and system-level contexts and mechanisms that influence ADPs are important knowledge gaps to be addressed by studies and to be incorporated in our program theory in the future. +2 more findings

• Care Services
• Caregiving

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Neuroinflammation and Tauopathies

45/100 ✓ Peer-reviewed Inflammation and the immune system Molecular biology reports

Key finding: This review combines current knowledge on the molecular and cellular mechanisms linking Tau pathology to chronic neuroinflammatory signaling, with a particular focus on microglia- and astrocyte-mediated responses. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

The Silent Crisis: Loneliness in Older Adults-A Critical Review of Impacts, Strategies and Path Forward

46/100 ✓ Peer-reviewed Health systems and care delivery Scandinavian journal of caring sciences

Key finding: Mechanisms include increased inflammation (↑CRP, IL-6), HPA dysregulation, immune compromise, hippocampal atrophy, and behavioural lapses. +4 more findings

• Lifestyle
• Policy

Full summary, score breakdown and related studies → Original source

Exossomos, Neuroinflamação e Biomarcadores Hematológicos na Doença de Alzheimer: revisão Sistemática

36/100 ✓ Peer-reviewed Tau biomarkers Revista Educação em Saúde/Revista Educação em Saúde Unievangélica

Key finding: Foram incluídos artigos originais e revisões publicados nos últimos 10 anos, em inglês, português ou espanhol, relacionados a exossomos neuronais, biomarcadores hematológicos, neuroinflamação e nanotecnologia aplicada à DA. +4 more findings

Full summary, score breakdown and related studies → Original source

Therapeutic monoclonal antibodies targeting amyloid beta in Alzheimer disease current evidence clinical outcomes limitations and future directions

31/100 ✓ Peer-reviewed Treatments Discover Neuroscience

Key finding: Recent regulatory approvals of aducanumab, lecanemab, and donanemab demonstrate significant plaque reduction and modest slowing of cognitive decline in early AD, supporting the amyloid hypothesis.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

PET Imaging in Alzheimer Disease: Diagnostic and Prognostic Applications

29/100 ✓ Peer-reviewed Biomarkers International Journal of Clinical and Medical Research

Key finding: Evidence indicates that amyloid PET is highly useful for establishing amyloid pathology, whereas tau PET is more closely associated with disease stage and clinical severity.

• Brain Scans
• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Transitional care needs of persons with dementia and their care partners: a secondary analysis using Transitions Theory

16/100 ⚠ Preprint — not yet peer-reviewed End-of-life care medRxiv

Key finding: When tailored transitional care guidance is lacking, care partners must take on significant responsibility for finding information and making decisions.

• Caregiving

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events

16/100 ⚠ Preprint — not yet peer-reviewed Treatments bioRxiv

Key finding: E4FAD mice demonstrated plaque reductions with accompanying increases in microhemorrhages (measured on both MRI and histology), and increases in microglial and astrocyte reactivity - especially in the perivascular compartment. +2 more findings

• Treatments
• Side Effects
• Genetics

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Oral Microbiome and Its Emerging Role in Alzheimer\'s Disease: A Comprehensive Review

36/100 ✓ Peer-reviewed Treatments Journal of Acute Care Trauma and Emergency Medicine

Key finding: Alzheimer's disease (AD) affects ~55 million people globally and is projected to rise steeply with population ageing.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers

58/100 ✓ Peer-reviewed Biomarkers JAMA Neurology

Key finding: In 272 participants, mean (SD) age was 70 (4.5) years, 270 were male (99.3%), and 83 (30.5%) were amyloid-PET positive. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source