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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 2,276–2,300 of 27,380 studies, newest first · page 92 of 1096.

December 2025 25

  1. 2025-12-01

    Brain Health PRO: Evaluating a Web‐Based Multidomain Intervention to Improve Dementia Literacy and Self‐Efficacy

    ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia

    Key finding: A covariate-adjusted linear mixed model for the intention-to-treat sample (N = 353; mean age = 69.7) revealed a significant positive change in dementia literacy at 6 months (standardized change = 0.246; p = 0.012) and a significant improvement in self-efficacy at 12 months (standardized change = 0.157; p = 0.008). +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2025-12-01

    Dietary Patterns and Risk of Age-Related Cognitive Decline and Dementia: Enthusiasm Before Evidence?

    ✓ Peer-reviewed Prevention trials Innovation in Aging

    Key finding: When systematically reviewed using the USDA Nutrition Evidence Systematic Review method and an a priori established protocol, a common theme emerged: diets characterized by higher consumption of vegetables, fruits, legumes, nuts, fish, seafood, and unsaturated vegetable oils, alongside lower intake of red and processed meats and sugar-sweetened beverages, are consistently associated with a reduced risk of cognitive decline and dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2025-12-01

    Diet‐Driven Metabolite Patterns Link the MIND Diet to Dementia Biomarkers

    ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia

    Key finding: Sample characteristics are shown in Table 1. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2025-12-01

    Multidomain intervention for preventiing cognitive decline among older adults with mild cognitive impairment ‐ Interim results from TINAGE trial

    ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia

    Key finding: During the one-year follow-up, the intervention group showed a significant increase in mean cognitive scores (Addenbrooke's cognitive examination), rising from 73.94 to 82.32 (p < 0.001). +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2025-12-01

    The Role of Diet in Dementia Prevention: Subjective and Objective Diet Scores

    ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia

    Key finding: 117 participants have complete data (mean age: 73 ± 7.4). +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2025-12-01

    The MIND diet association with lower microglial inflammation in the hippocampus: A Community‐Based Neuropathologic Study

    ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia

    Key finding: Higher MIND diet scores during the follow-up were associated with fewer reactive microglia (i.e., less neuroinflammation) in the hippocampus when controlled for age at death, sex, education, calories, and AD pathology (β=-0.035, SE=0.02, p = 0.045), but not with total microglia (β=-4.88, SE=3.08, p = 0.114). +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2025-12-01

    Mediterranean diet, gut microbiota, and cognitive decline in older adults with obesity/overweight and metabolic syndrome: a prospective cohort study

    ✓ Peer-reviewed Prevention trials BMC Medicine

    Key finding: Higher adherence to the MedDiet was associated with greater gut microbial diversity (p < 0.05) and distinct microbial composition (PERMANOVA, p = 0.001). +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2025-12-01

    Differential expression of conditioned medium from tauopathies patients' olfactory neuroepithelial precursor cells, implications in the neurodegeneration

    ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

    Key finding: hONE-NPCs expressed proteins such as Ki67, Nestin, GFAP, and b-III Tubulin, which are associated with cellular proliferation and the neuronal progenitor lineage. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2025-12-01

    Tau Protein and Neurodegeneration

    ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

    Key finding: The different Alzheimer and Pick tau folds establish the existence of molecular conformers of assembled tau. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2025-12-01

    Amygdala parcellation reveals unique subregions of atrophy in FTLD‐tauopathies

    ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

    Key finding: PPA/3R had a mean age of 63.5 years (SD = 3.9), PPA/4R were 72.5 years (SD = 5.8), and controls were 63.4 years (SD = 6.8). +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2025-12-01

    Amygdala parcellation reveals unique subregions of atrophy in FTLD‐tauopathies

    ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

    Key finding: PPA/3R had a mean age of 63.5 years (SD = 3.9), PPA/4R were 72.5 years (SD = 5.8), and controls were 63.4 years (SD = 6.8). +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2025-12-01

    Amygdala nuclei are not uniformly vulnerable to FTLD‐tauopathies in PPA

    ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

    Key finding: The basal nucleus showed significant neuronal loss in PPA versus controls (p <0.05). +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2025-12-01

    Targeting anaplastic lymphoma kinase (ALK) alleviates synaptic dysfunction associated with C9orf72 haploinsufficiency

    ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

    Key finding: Primary cortical neurons with C9orf72 haploinsufficiency exhibit alterations in dendritic branching, indicating disrupted neuronal connectivity. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2025-12-01

    Mice with pR927Q and pI712M Erbb4 Mutations Develop Features of Frontotemporal Dementia and ALS

    ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

    Key finding: Barnes Maze Acquisition was performed on males (N = 4-5/genotype) after habituation and several days training. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2025-12-01

    A human iPSC model of Tauopathies engineered for 4R Tau isoform expression endogenously develops late‐stage neuronal Tau pathology

    ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

    Key finding: We found that induction of adult human brain-like 4R Tau isoform expression enables endogenous formation of late-stage Tauopathy hallmarks in iPSC-derived neurons engineered to contain synergistic Tau mutations. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2025-12-01

    Monoamine Oxidase‐B (MAO‐B) Identifies Neurotoxic Reactive Astrocytes in Alzheimer's Disease and Related Dementias

    ✓ Peer-reviewed Inflammation and the immune system Alzheimer s & Dementia

    Key finding: Compared to controls, MAO-B immunoreactive area fraction was significantly increased in the frontal cortex and white matter of AD, CBD, and especially PiD and FTLD-TDP, but not PSP. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2025-12-01

    Irisin attenuates astrocyte activation and rescues memory in Alzheimer model mice

    ✓ Peer-reviewed Inflammation and the immune system Alzheimer s & Dementia

    Key finding: We demonstrate that irisin promotes the expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF), α5 subunits of integrin receptors and LDH5α, and stimulates transient activation of ERK 1/2 in astrocytes. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2025-12-01

    Microglia as a key player in Aβ‐related astrocyte reactivity

    ✓ Peer-reviewed Inflammation and the immune system Alzheimer s & Dementia

    Key finding: Our results suggest that microglial activation is a major phenomenon linking Aβ and astrocyte reactivity in the living AD brain. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2025-12-01

    Small Molecule Targeting of Chaperone {IP Protein} Prevents and Reverses TDP‐43 Aggregation In‐vitro and In‐vivo

    ✓ Peer-reviewed Brain tissue and pathology Alzheimer s & Dementia

    Key finding: Acute and chronic treatment of JRMS reduced TDP-25 aggregation in a dose-dependent manner by ∼75% in cells. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2025-12-01

    Novel immunoassays for TDP‐43 detection in plasma and CSF

    ✓ Peer-reviewed Brain tissue and pathology Alzheimer s & Dementia

    Key finding: The full length TDP-43 assay in standard format had a quantitative range of 10-275,000 pg/mL and sufficient sensitivity to quantitate 100% of the tested plasma samples. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2025-12-01

    Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?

    ✓ Peer-reviewed Brain tissue and pathology Alzheimer s & Dementia

    Key finding: Among 1,307 individuals, 36.9% were non-White and 49.7% were women. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2025-12-01

    TDP‐43 and APOE: A complex interaction

    ✓ Peer-reviewed Brain tissue and pathology Alzheimer s & Dementia

    Key finding: We identified an interaction between TDP-43 and APOE through immunoprecipitation followed by proteomics in mice, verified in human brain by co- immunoprecipitation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2025-12-01

    Investigation of the roles of microglia and astrocytes in cerebral amyloid angiopathy across diverse murine strains

    ✓ Peer-reviewed Brain tissue and pathology Alzheimer s & Dementia

    Key finding: We have shown that B6 and WSB genetic backgrounds are less susceptible to CAA compared to BXW, which develops robust CAA. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2025-12-01

    Detection of TDP‐43 seeds in CSF of presymptomatic and symptomatic genetic FTD/ALS

    ✓ Peer-reviewed Brain tissue and pathology Alzheimer s & Dementia

    Key finding: TDP-43 seeding activity was detected in 67% of TDP-43-linked symptomatic patients, with a specificity of 93%. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2025-12-01

    Associations of Cardiovascular‐Kidney‐Metabolic Syndrome with Psychiatric Disorders and Dementia in Midlife and Older adults in the UK Biobank

    ✓ Peer-reviewed Long-term cohort studies Alzheimer s & Dementia

    Key finding: Among 389,314 participants, CKM stages were distributed as follows: stage 0 (10.0%), stage 1 (8.0%), stage 2 (57.6%), stage 3 (17.9%), and stage 4 (6.5%). +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →