Newest studies

Effectiveness, safety, and biomarker dynamics of lecanemab in Chinese Alzheimer's disease population: a multicenter real-world study

56/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Lecanemab significantly attenuated cognitive decline versus ADNI. +4 more findings

• Biomarkers
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Advance care planning in Medicare beneficiaries with Alzheimer's disease and related dementias

41/100 ✓ Peer-reviewed End-of-life care Alzheimer s & Dementia Behavior & Socioeconomics of Aging

Key finding: ACP is linked to lower EOL spending and a shift from inpatient to outpatient ADRD care; structured ACP delivery should be considered.

• End-of-Life Care
• Policy

Full summary, score breakdown and related studies → Original source

Co‐Design of a Sleep Improvement Intervention for Persons Living With Dementia Boarding in the Emergency Department

36/100 ✓ Peer-reviewed Clinical safety Academic Emergency Medicine

Key finding: Twenty-six participants (15 ED clinicians, 3 caregivers, 8 community advisors) contributed perspectives. +4 more findings

• Lifestyle

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Bedside cognitive screening to detect dementia and predict poor outcomes in hospitals

54/100 ✓ Peer-reviewed Clinical safety Alzheimer s & Dementia

Key finding: Dementia prevalence was 22%, with 35% undiagnosed. +3 more findings

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Impact of annual wellness visits on preventing falls and fractures for Alzheimer’s disease and related dementias older adults

41/100 ✓ Peer-reviewed Clinical safety Age and Ageing

Key finding: AWVs were associated with reduced risks for falls (HR: 0.976 for 2 AWVs; 0.936 for ≥3 AWVs) and fractures (HR: 0.978 for 1 AWV; 0.960 for 2 AWVs; 0.927 for ≥3 AWVs), with greater reductions observed with more AVWs. +4 more findings

• Prevention

Full summary, score breakdown and related studies → Original source

Long‐term adherence and changes in the Mediterranean and MIND diets in relation to dementia risk and cognitive function

44/100 ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia

Key finding: Participants in the highest versus lowest MedDiet and MIND categories had 21% (hazard ratio [HR] = 0.79, 95% confidence interval [CI]: 0.73-0.84) and 14% (HR = 0.86, 95% CI: 0.81-0.91) lower dementia risk, respectively. +3 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

The spleen–brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation

35/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

Key finding: Emerging evidence highlights the central role of peripheral immune-metabolic regulation in the pathogenesis of Alzheimer's disease and related dementias (ADRD). +4 more findings

• Brain Biology
• Policy

Full summary, score breakdown and related studies → Original source

Psychometric modeling of Boston process approach data for dementia prediction in the Framingham Heart Study

42/100 ✓ Peer-reviewed Long-term cohort studies Journal of the International Neuropsychological Society

Key finding: Participants were older adults (mean age 71.5 ± 8.7 years), primarily female (54.2%), and non-Hispanic White (96.5%). +4 more findings

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Impact of anticoagulation on cognitive decline and clinical outcomes in patients with atrial fibrillation and dementia: A retrospective cohort study

49/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer s Disease Reports

Key finding: In this retrospective, confounder-adjusted study, anticoagulation was associated with slower cognitive/functional decline and lower hospitalization/mortality risk in AF and dementia patients. +2 more findings

• Diagnosis

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Developments on BACE 1 Inhibitors as Anti‐Alzheimer Agents: A Perspective on Medicinal Chemistry‐Based Advances

33/100 ✓ Peer-reviewed Risk genes beyond APOE Archiv der Pharmazie

Key finding: Numerous pathogenic hypotheses have been proposed to explain this mechanism; however, the amyloid cascade hypothesis remains the most widely accepted theory, as it suggests that β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) plays a critical role in the generation of Aβ peptides.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Discriminative Plasma Lipidomic Signatures of Dementia with Lewy Bodies and Alzheimer’s Disease: A Targeted Mass Spectrometry and Machine Learning Approach

46/100 ✓ Peer-reviewed Digital health tools Neuropsychiatric Disease and Treatment

Key finding: Significant alterations were observed in 7 lipid classes and 65 specific lipid species in DLB compared to AD. +4 more findings

• Digital Tools
• Other Dementias

Full summary, score breakdown and related studies → Original source

Effect of Mindfulness-Based Stress Reduction Activities on Family Caregiver Burden in Patients With Dementia—A Pilot Study

34/100 ✓ Peer-reviewed Caregiving Home Healthcare Now

Key finding: Following the intervention, caregivers demonstrated significant improvements, including reduced perceived burden, lower levels of depression, anxiety, and stress, and improved functional engagement. +1 more finding

• Caregiving

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Eye‐Tracking‐Based Cognitive Assessment Predicts the Risk of Memory Decline: A Community‐Based Cohort Study

56/100 ✓ Peer-reviewed Getting a diagnosis Geriatrics and gerontology international/Geriatrics & gerontology international

Key finding: Approximately half (54.5%, 35/55) of participants showed a decline in RBMT scores during the 2-year follow-up and were defined as the memory decline group. +3 more findings

• Diagnosis

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Relationship between APOE Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy

41/100 ✓ Peer-reviewed Genetics American Journal of Neuroradiology

Key finding: A total of 85 patients were included in the study with rare genotypes excluded from analysis (3 patients). +4 more findings

• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source

ACONAMI : A Case for Asian Mental Health Transformation

27/100 ✓ Peer-reviewed Health systems and care delivery Asia-Pacific Psychiatry

Key finding: Its collective ethos and measurable outputs provide a working model for advancing an Asian approach to mental health transformation, one that is equitable, culturally grounded, and globally relevant. +4 more findings

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Plasma Phosphorylated Tau 217 Cutoffs for Amyloid Pathology and Kidney Function, Body Mass Index, and Anemia

65/100 ✓ Peer-reviewed Getting a diagnosis JAMA neurology

Key finding: In the UGOT cohort, the optimal cutoff improved diagnostic accuracy compared with the standard single cutoff, particularly in CKD and anemia (CKD: from 0.65; 95% CI, 0.57-0.72; to 0.83; 95% CI, 0.76-0.89; anemia: from 0.80; 95% CI, 0.76-0.84; to 0.86; 95% CI, 0.82-0.90), with consistent findings in the Roche cohort. +3 more findings

Full summary, score breakdown and related studies → Original source

Time, talk, and teamwork: Perceptions of personalised dementia care planning conversations in primary care

41/100 ✓ Peer-reviewed End-of-life care PloS one

Key finding: A persistent gap remains between policy ambitions and everyday practice.

• Care Services

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Neighborhood food store and subsequent health and well-being of older adults in Japan: an outcome-wide study

46/100 ✓ Peer-reviewed Risk factors Archives of gerontology and geriatrics

Key finding: Compared to older adults who reported having many availability of neighborhood food stores, those reporting fewer stores were associated with less favorable outcomes in 5 of 7 domains; physical/cognitive health (low self-rated health and Instrumental activities of daily living), health behaviors (low frequency of going out), mental health (more depressive symptoms and hopeless), psychological well-being (low happiness and life satisfaction), cognitive social capital (low community attachment). +1 more finding

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A qualitative inquiry about end-of-life care for people with advanced dementia: “Planning ahead not in reality”

30/100 ✓ Peer-reviewed End-of-life care Geriatric Nursing

Key finding: Six key themes were identified: Inadequate preparation, guidance and access to appropriate resources; Taboo and misunderstanding: talking about death; Dementia as a terminal illness and the role of palliative care; Key time points, critical events and decisions; Planning ahead not in reality; Family issues and dynamics. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Circulating immune cell phenotypes are associated with inflammatory biomarkers in dementia-free participants from the Framingham Heart Study Offspring cohort

45/100 ✓ Peer-reviewed Long-term cohort studies Scientific Reports

Key finding: Higher levels of CD8 Cytotoxic T cells, CD8 + CD27-, CD8 effector T cells, and interferon gamma-producing CD8 T cells (Tc1) were all associated with higher levels of soluble CD8 alpha chain (CD8A). +3 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Vitamina E e outros antioxidantes na síndrome de Down para pacientes com demência: evidências iniciais com foco em marcadores genéticos

28/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Jornal de Assistência Farmacêutica e Farmacoeconomia

Key finding: No entanto, os resultados dos estudos clínicos apresentam divergências entre si, além de limitações metodológicas, pequeno tamanho amostral e variabilidade na definição dos desfechos. +4 more findings

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EEG microstate alterations in Parkinson’s disease dementia

36/100 ✓ Peer-reviewed Getting a diagnosis Scientific Reports

Key finding: Significant group differences were found in microstate dynamics. +3 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Predicting rates of cognitive and functional decline in Alzheimer’s disease and mild cognitive impairment

39/100 ✓ Peer-reviewed Mild cognitive impairment Communications Medicine

Key finding: The MMSE model achieves a mean absolute error (MAE) of 1.84 (95% CI: 1.64-2.04) internally and 2.19 in external validation. +4 more findings

• Early Stage

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Multi-class Alzheimer’s disease (AD) classification using Swin Transformer wavelet and Gray Wolf Optimization (GWO)

40/100 ✓ Peer-reviewed Brain scans and imaging Intelligence-Based Medicine

Key finding: This is while the EfficientNet model is the lightest in these criteria. • A hybrid deep learning framework combining Swin Transformer, wavelet transform, and Gray Wolf Optimization is proposed for multi-class Alzheimers disease MRI classification. • Wavelet decomposition enhances multi-scale frequency feature extraction, improving discrimination between dementia stages compared with baseline CNN models.

Full summary, score breakdown and related studies → Original source

Epilepsy and Alzheimer Disease: Epidemiologic, Clinical, Molecular, and Neuropathologic Convergences and Divergences

39/100 ✓ Peer-reviewed Tau biomarkers Neurology. Clinical practice

Key finding: Alzheimer disease (AD) and epilepsy are major causes of neurologic disability and are reciprocally related: epileptiform discharges, subclinical seizures, and epilepsy are more prevalent in patients with AD compared with controls; progressive cognitive impairment commonly afflicts epilepsy patients; and late-onset epilepsy patients have higher rates of new-onset dementia. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source