Newest studies

Cholinesterase inhibitors for patients with dementia: Patterns of prescribing and disparities in treatment

40/100 ✓ Peer-reviewed Disparities Journal of Alzheimer s Disease

Key finding: Repeated measures logistic regression was used to estimate the likelihood of ChEI fills by time-period, dementia type, and time x dementia type interaction to determine if change in prescription patterns significantly differed by diagnosis.

• Treatments
• Health Equity
• Other Dementias

Full summary, score breakdown and related studies → Original source

Filial Piety Under Pressure: A Qualitative Study of Dementia Caregiver Burdens in Rural China

36/100 ✓ Peer-reviewed Caregiving Journal of Gerontological Social Work

Key finding: China has the world's highest dementia prevalence, disproportionately impacting rural areas. +4 more findings

• Caregiving
• Health Equity

Full summary, score breakdown and related studies → Original source

Synthesis of Amyloid Images Using a Generative Adversarial Network from 2-Dimensional 18 F-FDG Images and Evaluation for Clinical Use

30/100 ✓ Peer-reviewed Brain scans and imaging Journal of Nuclear Medicine Technology

Key finding: Synthetic images were visually consistent, producing plausible negative and positive patterns while preserving continuity in the sagittal plane. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Validation of the Polish Version of Addenbrooke’s Cognitive Examination III in Mild Cognitive Impairment and Alzheimer’s Disease Dementia

42/100 ✓ Peer-reviewed Getting a diagnosis Dementia and Geriatric Cognitive Disorders

Key finding: Internal consistency of the ACE-III was strong (McDonald's ω = 0.889). +3 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Employing AI tools to predict features for dental care use in the United States during the global respiratory illness outbreak

46/100 ✓ Peer-reviewed Health systems and care delivery Frontiers in Public Health

Key finding: Oral health is strongly associated with overall health. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Semaglutide Attenuates Neuroinflammation in Mice

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv

Key finding: Together, these findings reveal how GLP-1R signaling orchestrates resolution of neuroinflammation through coordinated multi-cellular programs.

• Brain Biology
• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Nutritional and physical pathways from feeding difficulty to sarcopenia in Alzheimer’s dementia

42/100 ✓ Peer-reviewed Prevention trials Frontiers in Nutrition

Key finding: Individuals with Alzheimer’s dementia exhibited poorer nutritional status (EdFED: 8.0 vs. 2.0; NUFFE: 10.0 vs. 7.0; both p < 0.001) and lower adherence to the Mediterranean diet (6.0 vs. 7.0; p = 0.050). +2 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP‐43 Mouse Model of Frontotemporal Dementia

41/100 ✓ Peer-reviewed Brain tissue and pathology The FASEB Journal

Key finding: The duodenum, jejunum, and ileum of TDP-43 overexpressing versus wildtype mice were investigated.

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Data-driven clinical decision support tool for diagnosing mild cognitive impairment in Parkinson’s disease

53/100 ✓ Peer-reviewed Mild cognitive impairment npj Parkinson s Disease

Key finding: This finding suggests that ML models can complement clinical assessments, by facilitating the detection of MCI and complementing the diagnostic characterisation of PwPD.

• Early Stage
• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome

46/100 ✓ Peer-reviewed Down syndrome and Alzheimer's JAMA Neurology

Key finding: This cross-sectional study examines data for participants in the Alzheimer Biomarker Consortium–Down Syndrome study to gauge the concordance of clinical and biological Alzheimer disease staging.

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Systemic complement factors in aging, Alzheimer's disease and other dementias: a longitudinal study over 10 years

52/100 ✓ Peer-reviewed Laboratory science Molecular Neurodegeneration

Key finding: The results of this study indicate an AD-specific peripheral complement signature associated with disease development, highlighting complement factors as critical immune mediators that link aging and AD. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Epigenomics in Understanding Racial Disparities of Alzheimer’s Disease and Related Dementias

38/100 ✓ Peer-reviewed Disparities International Journal of Molecular Sciences

Key finding: The few AD studies conducted on minority populations in the US have found that significant AD health disparities exist, demonstrating that African Americans and Hispanics have a significantly higher prevalence of AD and related dementias, with their risk often approaching twice that of White individuals.

• Health Equity
• Genetics

Full summary, score breakdown and related studies → Original source

Curcuma longa-Derived Curcumin Nanoparticles in Experimental Models of Alzheimer’s Disease: A Formulation-Based Approach

27/100 ✓ Peer-reviewed Treatments Probecell Science

Key finding: The particle size of formulation F6 was optimal, the polydispersity index was minimised, the efficiency of encapsulation maximised, and a long-term drug release profile was demonstrated. +2 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Resting-State EEG captures functional network correlates of plasma p-Tau-217 in Alzheimer's disease

54/100 ✓ Peer-reviewed Biomarkers NeuroImage. Clinical

Key finding: AD-MCI and AD-DEM patients showed increased p-tau217 and spectral slowing (higher theta, lower alpha). +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Real world clinical practice of lecanemab at PUMCH dementia cohort: focus on dynamic imaging and biomarker evolution

48/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s Research & Therapy

Key finding: A significant median Centiloid reduction of 30.9 was observed, with a 24.1% amyloid PET negativity rate after six months. +2 more findings

• Brain Scans
• Treatments

Full summary, score breakdown and related studies → Original source

HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs

39/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of Disease

Key finding: Together, our findings establish a mechanistic link between HOPS loss-of-function and aberrant APP processing, with implications for neurodegeneration. • HOPS impairment blocks retromer-mediated recycling of APP to the TGN. • HOPS impairment redistributes APP to static late endosomes in soma and den

• Digital Tools

Full summary, score breakdown and related studies → Original source

Assistive Intelligence: A Framework for AI-Powered Technologies Across the Dementia Continuum

37/100 ✓ Peer-reviewed Digital health tools Journal of Ageing and Longevity

Key finding: These are mapped across four core domains: cognition, mental health, physical health and independence, and caregiver support. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

An Ensemble Learning Artificial Intelligence Model for Alzheimer's Disease Detection Using OCT

54/100 ✓ Peer-reviewed Digital health tools Ophthalmology Science

Key finding: For detecting AD-dementia, the ensemble model achieved the area under the receiver operating characteristic curve (AUROC) of 0.943 (95% confidence interval, 0.906-0.980), 0.786 (95% confidence interval, 0.673-0.899), and 0.795 (95% confidence interval, 0.716-0.874) in the internal validation, External-1, and External-2, respectively. +3 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Metabolites released from apoptotic cells in central nervous system orchestrates the pathological process of Alzheimer disease through improving autophagy

40/100 ✓ Peer-reviewed Biomarkers Autophagy

Key finding: As a result, although there is an increased formation of autophagosomes, misfolded proteins fail to undergo proper degradation in the subsequent process. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Prevalence and outcomes of recorded dementia vary by data source: a population cohort study of 133,407 older adults

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety medRxiv

Key finding: Dementia is variably recorded across routine datasets, and the setting in which dementia is first recorded identifies groups with markedly different prognosis.

• Care Services

Scored 53 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Exercise and Brain Health: Expert Review

45/100 ✓ Peer-reviewed Brain scans and imaging American journal of lifestyle medicine

Key finding: Overall, both aerobic and anaerobic exercises are integral and complementary to preserving brain health through effects on cognitive function and brain structure.

• Brain Scans
• Lifestyle

Full summary, score breakdown and related studies → Original source

A Systematic Review to Evaluate the Effect of Neflamapimod on Cognitive Function and Progression of Dementia

44/100 ✓ Peer-reviewed Inflammation and the immune system Neurology India

Key finding: Treatment options for dementia mainly comprise of symptomatic treatment, as no disease-modifying therapy currently exists that directly reduces the pathology. +2 more findings

• Brain Biology
• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

Place of death for people with dementia: A scoping review

40/100 ✓ Peer-reviewed End-of-life care PLoS ONE

Key finding: After screening, a total of 48 studies were included in this review. +4 more findings

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Association of Palliative Care Initiation With Acute Healthcare Utilization Among Community‐Dwelling Adults Living With Dementia

52/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: Palliative care was associated with a higher risk of hospitalization in the first 90 days (e.g., hazard ratio (HR) 1.43 at 30 days; 95% confidence interval (CI) 1.25-1.64), which was driven predominantly by hospitalization with palliative intent, but was no longer significantly different beyond 180 days, compared to not receiving palliative care. [Correction added on 31 January 2026, after first online publication: The preceding sentence has been revised in this version.] +4 more findings

• End-of-Life Care
• Risk Factors

Full summary, score breakdown and related studies → Original source

Pharmacological Advances in Targeting Neuroinflammation for Alzheimer’s Disease

28/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Pharmaceutical Technology Research and Management

Key finding: Mechanistic studies demonstrate that pharmacological modulation of microglial phenotypes inhibition of pro inflammatory mediators TNF alpha IL 1 IL 6 and targeting pathways such as NF kappa B NLRP3 inflammasome p38 MAPK JAK STAT and TREM2 can attenuate neuroinflammatory cascades and reduce amyloid beta and tau associated neurotoxicity. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source