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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 16,126–16,150 of 27,380 studies, newest first · page 646 of 1096.

April 2016 25

  1. 2016-04-22

    Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes

    ✓ Peer-reviewed Disease mechanisms Scientific reports

    Key finding: This study showed that rat bone marrow mesenchymal stem cells (BM-MSCs) can improve the cognitive impairments of STZ-diabetic mice by repairing damaged neurons and astrocytes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2016-04-21

    Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses

    ✓ Peer-reviewed Genetics Nature communications

    Key finding: A common approach to understanding neurodegenerative disease is comparing gene expression in diseased versus healthy tissues.

    Full summary, score breakdown and related studies → Original source

  3. 2016-04-21

    Whole-Genome Sequencing of a Healthy Aging Cohort

    ✓ Peer-reviewed Genetics Cell

    Key finding: Studies of long-lived individuals have revealed few genetic mechanisms for protection against age-associated disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2016-04-21

    Alzheimer disease genetic risk factor APOE e4 and cognitive abilities in 111,739 UK Biobank participants

    ✓ Peer-reviewed Long-term cohort studies Age and ageing

    Key finding: Carriers of the e4 allele may be more vulnerable to conditions that are independent risk factors for cognitive decline, such as cardiometabolic diseases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2016-04-21

    Targeting microglia for the treatment of Alzheimer's Disease

    ✓ Peer-reviewed TREM2 and immune genetics Glia

    Key finding: Coding and noncoding polymorphisms in several genes expressed in microglia-including APOE, TREM2, CD33, GRN, and IL1RAP-alter AD risk, and therefore could be considered as entry points for therapeutic intervention. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2016-04-21

    Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death

    ✓ Peer-reviewed Lewy body dementia The EMBO journal

    Key finding: Here, we found that C9ORF72 forms a complex with the WDR41 and SMCR8 proteins to act as a GDP/GTP exchange factor for RAB8a and RAB39b and to thereby control autophagic flux. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2016-04-21

    Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

    ✓ Peer-reviewed Lewy body dementia Neuron

    Key finding: Disease mechanisms were evaluated in mice expressing C9ORF72 RNAs with up to 450 GGGGCC repeats or with one or both C9orf72 alleles inactivated. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2016-04-21

    Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

    ✓ Peer-reviewed Lewy body dementia Cell

    Key finding: Remarkably, deleting C1qa gene significantly reduces synaptic pruning by Grn(-/-) microglia and mitigates neurodegeneration, behavioral phenotypes, and premature mortality in Grn(-/-) mice. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2016-04-21

    Hearing Their Voice: A Systematic Review of Dementia Family Caregivers' Needs

    ✓ Peer-reviewed Caregiving The Gerontologist

    Key finding: Two themes were developed from 12 studies: caregiver needs related to the management of older people with dementia and caregivers' personal needs.

    Full summary, score breakdown and related studies → Original source

  10. 2016-04-20

    Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds

    ✓ Peer-reviewed Risk genes beyond APOE Neuron

    Key finding: We conclude that the PSEN1-L435F and -C410Y mutations are extreme examples of the previously proposed "dysfunction" of γ-secretase that characterizes FAD-associated PSEN.

    Full summary, score breakdown and related studies → Original source

  11. 2016-04-20

    Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer's disease treatment

    ✓ Peer-reviewed Treatments Colloids and surfaces. B, Biointerfaces

    Key finding: New drugs, such as peptide iAβ5, capable to inhibit the aggregates associated with Alzheimeŕs disease (AD) are being tested but the most frequent drawback is to reach the brain in the desired concentrations due to the low BBB permeability-surface area. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2016-04-20

    Genome instability in Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Mechanisms of ageing and development

    Key finding: Autosomal dominant, familial AD (fAD) is very rare and caused by mutations in amyloid precursor protein (APP), presenilin-1 (PSEN-1), and presenilin-2 (PSEN-2) genes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2016-04-19

    Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels

    ✓ Peer-reviewed Cognitive tests and assessment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: Knight Alzheimer's Disease Research Center (ADRC) at Washington University (WU). +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2016-04-19

    A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II

    ✓ Peer-reviewed How common it is Nature communications

    Key finding: At 2 years CFAS I interviewed 5,156 (76% response) with 5,288 interviewed in CFAS II (74% response). +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2016-04-19

    Poor self-rated health did not increase risk of permanent nursing placement or mortality in people with mild Alzheimer's disease

    ✓ Peer-reviewed Treatments BMC geriatrics

    Key finding: When poor SRH was present we found no increased risk for NH placement or death among elderly people with mild AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2016-04-18

    The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients

    ✓ Peer-reviewed Clinical safety Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Cognitive decline after surgery is biphasic and accelerated among persons with delirium.

    Full summary, score breakdown and related studies → Original source

  17. 2016-04-18

    TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

    ✓ Peer-reviewed TREM2 and immune genetics The Journal of experimental medicine

    Key finding: Rare TREM2 variants that affect TREM2 function lead to an increased risk of developing AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2016-04-15

    CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

    ✓ Peer-reviewed Genetics Nature communications

    Key finding: Interrogation of international cohorts identified additional novel CCNF variants in familial and sporadic ALS and FTD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2016-04-15

    Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Amyloid-positive cognitively healthy participants showed a significant increase in mI/creatine and mI/NAA levels compared to amyloid-negative healthy elderly (p Conclusions mI levels are elevated already at asymptomatic stages of AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2016-04-13

    Many people in Scotland now benefit from anticipatory care before they die: an after death analysis and interviews with general practitioners

    ✓ Peer-reviewed End-of-life care BMJ supportive & palliative care

    Key finding: GPs are identifying patients for anticipatory and palliative care more equitably across the different disease trajectories and earlier in the disease process than they were previously identifying patients specifically for palliative care. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2016-04-12

    Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults

    ✓ Peer-reviewed Biomarkers Journal of Alzheimer s Disease

    Key finding: Higher HOMA-IR was associated with higher sAβPPβ and Aβ42 . +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2016-04-12

    The association between aspects of daily life and quality of life of people with dementia living in long-term care facilities: a momentary assessment study

    ✓ Peer-reviewed Cognitive tests and assessment International psychogeriatrics

    Key finding: The results underline the importance of social interaction and a positive mood for a higher QoL. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2016-04-12

    Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

    ✓ Peer-reviewed Inflammation and the immune system Trends in neurosciences

    Key finding: However, recent studies in mice have revealed that CSF-1R signaling directly controls the development and maintenance of microglia, and cell autonomously regulates neuronal differentiation and survival. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2016-04-12

    Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia

    ✓ Peer-reviewed Long-term cohort studies Stroke

    Key finding: The American Heart Association developed the ideal cardiovascular health (CVH) index as a simple tool to promote CVH; yet, its association with brain atrophy and dementia remains unexamined. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2016-04-11

    Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration

    ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of clinical investigation

    Key finding: We found that the full-length wild-type APP (APPWT) and β-CTF both induced endosomal enlargement and disrupted NGF signaling and axonal trafficking. β-CTF alone induced atrophy of BFCNs that was rescued by the dominant-negative Rab5 mutant, Rab5S34N.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →