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Poor self-rated health did not increase risk of permanent nursing placement or mortality in people with mild Alzheimer's disease
Nielsen AB, Siersma V, Waldemar G, Waldorff FB.. BMC geriatrics, 2016-04-19
Topic: Amyloid, tau and blood-test diagnosis
Background Self-rated health (SRH) has in many population-based studies predicted adverse health outcomes, e.g. morbidity, permanent nursing home (NH) placement, and mortality. However, the predictive value of SRH to NH placement and mortality among elderly people is not consistent. This may be due to cognitive impairment. Since the SRH item is widely used, it is important to know whether SRH has different predictive value among people with cognitive impairments. We aimed to examine SRH and the risk of permanent NH placement and mortality among people with mild Alzheimer's disease (AD). Methods Data are from The Danish Alzheimer Intervention StudY (DAISY), a large randomized controlled trial of psychosocial intervention for patients with mild dementia and their caregivers with 3-years' follow-up. Five out of 14 Danish counties participated and 321 home-living elderly (mean age: 76.2 years) with mild AD (46.4 % male) were included during 2004 and 2005. Self-rated SRH, cognitive function (MMSE), quality of life (proxy-rated QOL-AD), activities of daily living (ADCS-ADL), insight, and socio-demographics were assessed at baseline. Comorbidities and information about NH placement and mortality was obtained over 3-years' follow-up from registries. With Cox proportional hazard regression we analysed the association between SRH (dichotomised into good vs. poor) and NH placement and mortality adjusted for potential confounders. Results At baseline 66 % reported excellent or good, and 34 % fair, poor or very poor SRH. Mean MMSE was 24.0 (range: 20-30). NH placement and mortality totalled 28.1 % and 16.5 % at 3-years' follow-up, respectively. Poor SRH at baseline was not related to increased risk of NH placement or to increased mortality neither in the univariable nor in multivariable analysis: In the fully adjusted models HR was 0.63 (95 % CI 0.38-1.05) and 1.28 (95 % CI 0.67-2.45), respectively. Conclusions When poor SRH was present we found no increased risk for NH placement or death among elderly people with mild AD. SRH is a widely used parameter in clinical and epidemiological research but may not be a valid indicator of health in patients with AD due to loss of insight.
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APA 7th
Nielsen, A. B., Siersma, V., Waldemar, G., & Waldorff, F. B. (2016). Poor self-rated health did not increase risk of permanent nursing placement or mortality in people with mild Alzheimer's disease. BMC geriatrics. https://doi.org/10.1186/s12877-016-0262-x
Vancouver
Nielsen AB, Siersma V, Waldemar G, Waldorff FB. Poor self-rated health did not increase risk of permanent nursing placement or mortality in people with mild Alzheimer's disease. BMC geriatrics. 2016. doi:10.1186/s12877-016-0262-x. PMID: 27094158.
BibTeX
@article{nielsen2016-27094158,
author = {Nielsen, A. B. and Siersma, V. and Waldemar, G. and Waldorff, F. B.},
title = {{Poor self-rated health did not increase risk of permanent nursing placement or mortality in people with mild Alzheimer's disease}},
journal = {BMC geriatrics},
year = {2016},
doi = {10.1186/s12877-016-0262-x},
pmid = {27094158},
url = {https://doi.org/10.1186/s12877-016-0262-x}
}
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Key findings
- Results At baseline 66 % reported excellent or good, and 34 % fair, poor or very poor SRH.
- Poor SRH at baseline was not related to increased risk of NH placement or to increased mortality neither in the univariable nor in multivariable analysis: In the fully adjusted models HR was 0.63 (95 % CI 0.38-1.05) and 1.28 (95 % CI 0.67-2.45), respectively.
- Conclusions When poor SRH was present we found no increased risk for NH placement or death among elderly people with mild AD.
Why it matters
In 321 home-living elderly people with mild Alzheimer's disease, poor self-rated health was not linked to increased risk of nursing home placement or death over three years. This concerns prediction of these outcomes, not treating, curing, or preventing the disease.
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Study details
- Study designrandomized controlled trial
- Evidence strengthHigh
How this study scored 54/100
Published in a peer-reviewed journal, and it is a randomized controlled trial. Scored zero for sample size and effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (BMC geriatrics) |
| Journal's citation record | 2 / 4 | BMC Geriatrics: journal h-index 153 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomized controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomized / blinded | 1 / 2 | Randomized (as stated in the record) |
| Times cited | 3 / 7 | Cited 15 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.2 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 2 / 6 | Cited 1.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Frans Boch Waldorff: h-index 32 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Copenhagen: institution h-index 1,378 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27094158) |
| Free to read | 2 / 2 | Free to read |
| Total | 54 / 100 | — |
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