Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 14,876–14,900 of 27,380 studies, newest first · page 596 of 1096.
July 2017 25
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2017-07-28
Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer's disease
64/100 ✓ Peer-reviewed Long-term cohort studies Scientific reports
Key finding: We analyzed 5-year longitudinal outcomes and biomarker data from 562 subjects with mild cognitive impairment (MCI) from two national studies (ADNI) using a novel multilayer clustering algorithm. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-28
In vivo retention of 18F-AV-1451 in corticobasal syndrome
51/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Patients with CBS without typical AD pathology exhibited AV-1451 retention in the motor cortex, corticospinal tract, and basal ganglia contralateral to the affected body side, clearly different from controls and patients with AD dementia or PSP. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-07-27
Significance of long chain polyunsaturated fatty acids in human health
41/100 ✓ Peer-reviewed Prevention and risk Clinical and translational medicine
Key finding: Recent findings reviewed in the present study highlight that the omega-6 fatty acid ARA appears increased, and omega-3 EPA and DHA decreased in most cancer tissues compared to normal ones, and that increments in omega-3 LC-PUFAs consumption and an omega-6/omega-3 ratio of 2-4:1, are associated with a reduced risk of breast, prostate, colon and renal cancers. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-07-27
Epidemiology and outcomes of people with dementia, delirium, and unspecified cognitive impairment in the general hospital: prospective cohort study of 10,014 admissions
60/100 ✓ Peer-reviewed Clinical safety BMC medicine
Key finding: CSD is common in older inpatients and associated with considerably worse outcomes, with little variation between different types of CSD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-26
18F-Flortaucipir PET/MRI Correlations in Nonamnestic and Amnestic Variants of Alzheimer Disease
39/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: The subgroups showed the expected 18F-flortaucipir-binding patterns. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-26
AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: Defining a summary measure
52/100 ✓ Peer-reviewed Biomarkers NeuroImage
Key finding: We additionally validated this summary metric in a cohort of 13 Alzheimer disease patients, and showed that this measure correlates with cognitive dysfunction and β-amyloid PET imaging in a diseased population.
Full summary, score breakdown and related studies → Original source
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2017-07-24
Can a tablet-based cancellation test identify cognitive impairment in older adults?
45/100 ✓ Peer-reviewed Cognitive tests and assessment PloS one
Key finding: In the MCI group, age (B = -0.37, p<0.001) and current daily use of computer-based devices (B = 5.85, p<0.001) were associated with the number of correct cancellations of the e-CT. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-24
Necroptosis activation in Alzheimer's disease
41/100 ✓ Peer-reviewed Genetics Nature neuroscience
Key finding: We found that necroptosis was activated in postmortem human AD brains, positively correlated with Braak stage, and inversely correlated with brain weight and cognitive scores. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-24
Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia
47/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of clinical investigation
Key finding: Activated microglia are a universal feature of ALS/FTD pathology; however, their role in disease pathogenesis remains incompletely understood. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-24
Functional correlates of TSH, fT3 and fT4 in Alzheimer disease: a F-18 FDG PET/CT study
43/100 ✓ Peer-reviewed Tau biomarkers Scientific reports
Key finding: We evaluated 87 subjects (37 males and 50 females, mean age 70 (±6) years old) with AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-22
Hearing Impairment and Incident Dementia: Findings from the English Longitudinal Study of Ageing
72/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society
Key finding: Older adults with hearing loss are at greater risk of dementia than those with normal hearing. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-22
Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study
51/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Atrophy rates are pathologically increased up to seven years before "expected onset".
Full summary, score breakdown and related studies → Original source
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2017-07-21
A re-examination of Montreal Cognitive Assessment (MoCA) cutoff scores
66/100 ✓ Peer-reviewed Mild cognitive impairment International journal of geriatric psychiatry
Key finding: A MoCA cutoff score of 23, rather than the initially recommended score of 26, lowers the false positive rate and shows overall better diagnostic accuracy. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-21
Dementia prevalence and incidence in a federation of European Electronic Health Record databases: The European Medical Informatics Framework resource
41/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The European Medical Information Framework initiative supports EHR data on unprecedented number of people with dementia.
Full summary, score breakdown and related studies → Original source
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2017-07-21
A Review of Fluid Biomarkers for Alzheimer's Disease: Moving from CSF to Blood
57/100 ✓ Peer-reviewed Biomarkers Neurology and therapy
Key finding: Both plasma tau and NFL are increased in AD, and a recent study showed that plasma NFL has a diagnostic performance comparable to the core AD CSF biomarkers, and predicted future cognitive decline.
Full summary, score breakdown and related studies → Original source
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2017-07-21
Quasi-experimental evaluation of a multifaceted intervention to improve quality of end-of-life care and quality of dying for patients with advanced dementia in long-term care institutions
47/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: Our multidimensional intervention in long-term care facilities for patients with terminal dementia resulted in improved quality of care and quality of dying when compared to usual care. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-21
Sleep characteristics and risk of dementia and Alzheimer's disease: The Atherosclerosis Risk in Communities Study
57/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This study tested the hypotheses that late-midlife obstructive sleep apnea (OSA) and short and long sleep duration are associated with dementia over 15 years of follow-up. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-21
Motor speech signature of behavioral variant frontotemporal dementia: Refining the phenotype
43/100 ✓ Peer-reviewed Digital health tools Neurology
Key finding: One in 8 patients presented with moderate speech timing deficits with a further two-thirds rated as mild or subclinical. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-07-20
FGWAS: Functional genome wide association analysis
48/100 ✓ Peer-reviewed Genetics NeuroImage
Key finding: Compared with the standard multivariate regression model, the multivariate varying coefficient model explicitly models the functional features of functional phenotypes through the integration of smooth coefficient functions and functional principal component analysis. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-07-20
Dementia prevention, intervention, and care
65/100 ✓ Peer-reviewed Prevention and risk The Lancet
Full summary, score breakdown and related studies → Original source
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2017-07-20
A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone
69/100 ✓ Peer-reviewed Treatments Genetics in medicine : official journal of the American College of Medical Genetics
Key finding: PurposeTelephone disclosure of genetic test results can improve access to services. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-19
Drug candidates in clinical trials for Alzheimer's disease
50/100 ✓ Peer-reviewed Inflammation and the immune system Journal of biomedical science
Key finding: AD is the most common neurodegenerative disease worldwide, affecting one-fifth of those aged over 85 years. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-19
Serum Interleukin-10 Levels Correlate with Cerebrospinal Fluid Amyloid Beta Deposition in Alzheimer Disease Patients
44/100 ✓ Peer-reviewed Tau biomarkers Neuro-degenerative diseases
Key finding: In Alzheimer disease (AD) inflammation becomes evident throughout the course of the disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-19
Automatic measurement of prosody in behavioral variant FTD
51/100 ✓ Peer-reviewed Digital health tools Neurology
Key finding: Reduced f0 range reflects impaired prosody in bvFTD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-07-18
A systematic review of the prevalence of comorbid cancer and dementia and its implications for cancer-related care
69/100 ✓ Peer-reviewed End-of-life care Aging & mental health
Key finding: There is a dearth of good-quality evidence investigating the cancer-dementia prevalence and its implications for successful cancer treatment. +2 more findings
Full summary, score breakdown and related studies → Original source
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