Newest studies

Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice

38/100 ✓ Peer-reviewed Drug development Journal of neurochemistry

Key finding: Increasing evidence has shown that type 2 diabetes (T2D) is a risk factor for Alzheimer's disease. +2 more findings

• Brain Biology
• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease

54/100 ✓ Peer-reviewed Brain tissue and pathology Human brain mapping

Key finding: Identifying the earliest neurodegenerative changes associated with each variant has implications for early diagnosis, and for understanding the mechanisms that underlie regional vulnerability and disease progression in AD. +3 more findings

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Cognitive reserve and lifestyle: moving towards preclinical Alzheimer's disease

38/100 ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience

Key finding: While some of these investigations are in agreement with the compensatory view of cognitive reserve, other studies have revealed new clues on the neural mechanisms underlying beneficial effects of lifestyle factors on the brain. +1 more finding

• Early Stage
• Lifestyle

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ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing

47/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry

Key finding: Crossing ABCA7-deficient animals to an APP transgenic model resulted in significant increases in the soluble Aβ as compared with mice expressing normal levels of ABCA7. +1 more finding

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Mapping CSF biomarker profiles onto NIA-AA guidelines for Alzheimer's disease

49/100 ✓ Peer-reviewed Tau biomarkers European archives of psychiatry and clinical neuroscience

Key finding: These results enrich the discussion on the NIA-AA guidelines and point to a discordance between clinical symptomatology and CSF biomarkers even in patients with full-blown AD dementia, who are supposed to have a clearly positive for AD neurochemical profile.

• Biomarkers

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Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

36/100 ✓ Peer-reviewed Disease mechanisms Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Key finding: Excessive stimulation of NAD(P)H and electron transport chain leads to the overproduction of ROS, results in oxidative stress, which is a good mediator to injure the cell structures, lipids, proteins, and DNA.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder

48/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience

Key finding: The intervention group increased in global cognition compared to the control group, p = 0.002, Cohen's d = 0.31. +3 more findings

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Functional Significance of TDP-43 Mutations in Disease

46/100 ✓ Peer-reviewed Brain tissue and pathology Advances in genetics

Key finding: However, almost all patients affected by ALS or tau-negative FTD share in their brains the presence of aggregated TDP-43, a nuclear factor that plays an important role in regulating RNA metabolism. +3 more findings

• Brain Biology

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Optical Coherence Tomography in Alzheimer's Disease: A Meta-Analysis

69/100 ✓ Peer-reviewed Mild cognitive impairment PloS one

Key finding: 11 studies were identified, including 380 patients with AD, 68 with MCI and 293 healthy controls (HC). +3 more findings

• Early Stage

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P50: A candidate ERP biomarker of prodromal Alzheimer's disease

48/100 ✓ Peer-reviewed Tau biomarkers Brain research

Key finding: MCI-AD patients yielded larger P50s than MCI-Other. +3 more findings

• Biomarkers
• Early Stage

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18F-FDG PET Improves Diagnosis in Patients with Focal-Onset Dementias

44/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Brain 18F-FDG PET scans interpreted with Neurostat and 3D-SSP displays accurately detected Alzheimer disease in patients with primary progressive aphasia or corticobasal syndrome as focal-onset dementias. +1 more finding

• Brain Scans
• Diagnosis

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Therapeutic strategies for Alzheimer's disease in clinical trials

36/100 ✓ Peer-reviewed Treatments Pharmacological reports : PR

Key finding: Interesting results have also been achieved in trials involving small molecules such as inhibitors of β-secretase (MK-8931, E2609), a combination of 5-HT6 antagonist (idalopirdine) with donepezil, inhibition of advanced glycation end product receptors by azeliragon or modulation of the acetylcholine response of α-7 nicotinic acetylcholine receptors by encenicline.

• Treatments
• Clinical Trials
• Brain Biology

Full summary, score breakdown and related studies → Original source

Advance Care Planning in Nursing Home Patients With Dementia: A Qualitative Interview Study Among Family and Professional Caregivers

43/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

Key finding: ACP is a multifactorial process, which may lean on professional caregivers' guidance. +1 more finding

• Caregiving
• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

52/100 ✓ Peer-reviewed Risk factors Nature reviews. Neuroscience

Key finding: Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is associated with a greatly increased risk of early-onset Alzheimer disease.

• Risk Factors
• Genetics
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease

67/100 ✓ Peer-reviewed Treatments International journal of nanomedicine

Key finding: Alzheimer's disease is a neurological disorder that results in cognitive and behavioral impairment.

• Treatments

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The Role of Oxidative Damage in the Pathogenesis and Progression of Alzheimer's Disease and Vascular Dementia

42/100 ✓ Peer-reviewed Prevention and risk Oxidative medicine and cellular longevity

Key finding: Oxidative stress (OS) has been demonstrated to be involved in the pathogenesis of the two major types of dementia: Alzheimer's disease (AD) and vascular dementia (VaD).

• Other Dementias

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Complementarity of visual and voxel-based FDG-PET analysis to detect MCI-like hypometabolic pattern in elderly patients with hypertension and isolated memory complaints

46/100 ✓ Peer-reviewed Risk factors Acta Radiologica

Key finding: An MCI-like hypometabolic pattern was documented in 5 patients (7%) by SVA and 7 patients (10%) by SPM analysis; however, only 2 of these patients were selected by both methods. +3 more findings

• Risk Factors
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

A genome-wide association study of late-onset Alzheimer's disease in a Japanese population

38/100 ✓ Peer-reviewed Genetics Psychiatric genetics

Key finding: Our data indicated that 18p11.32 (rs1992269, P = 9.77 × 10(-7)), CNTNAP2 (rs802571, P = 1.26 × 10(-6)), and 12q24.23 (rs11613092, P = 6.85 × 10(-6)) were suggestive loci for susceptibility to LOAD. +2 more findings

• Genetics

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NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein

41/100 ✓ Peer-reviewed Brain tissue and pathology Science (New York, N.Y.)

Key finding: Extracellular deposits of Aβ and intraneuronal tau inclusions define Alzheimer's disease, whereas intracellular inclusions of α-synuclein make up the Lewy pathology of Parkinson's disease. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients

70/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: These findings describe solanezumab effects on efficacy/safety measures in a mild AD population. +2 more findings

• Clinical Trials
• Treatments

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Palliative care in dementia: literature review of nurses' knowledge and attitudes towards pain assessment

57/100 ✓ Peer-reviewed End-of-life care International journal of palliative nursing

Key finding: Nurses play a key role in the effective management of pain through the use of pain assessment tools, behavioural observation, and analgesic choice. +1 more finding

• End-of-Life Care

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A multicenter study of the early detection of synaptic dysfunction in Mild Cognitive Impairment using Magnetoencephalography-derived functional connectivity

41/100 ✓ Peer-reviewed Disease mechanisms NeuroImage. Clinical

Key finding: The changes in network synchronization are evident in patients with Mild Cognitive Impairment (MCI) at the group level, but there are very few Magnetoencephalography (MEG) studies regarding discrimination at the individual level. +4 more findings

• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update

39/100 ✓ Peer-reviewed TREM2 and immune genetics Archivum immunologiae et therapiae experimentalis

Key finding: Since the first description of AD in 1907, many hypotheses have been established to explain its causes. +3 more findings

• Genetics
• Brain Biology

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R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

55/100 ✓ Peer-reviewed Risk genes beyond APOE JAMA neurology

Key finding: The R47H variant in the triggering receptor expressed on myeloid cells 2 gene (TREM2), a modulator of the immune response of microglia, is a strong genetic risk factor for Alzheimer disease (AD) and possibly other neurodegenerative disorders. +3 more findings

• Genetics
• Brain Biology
• Caregiving

Full summary, score breakdown and related studies → Original source

New Clinical Subtypes of Parkinson Disease and Their Longitudinal Progression: A Prospective Cohort Comparison With Other Phenotypes

65/100 ✓ Peer-reviewed Mild cognitive impairment JAMA neurology

Key finding: The best cluster solution found was based on orthostatic hypotension, mild cognitive impairment, rapid eye movement sleep behavior disorder (RBD), depression, anxiety, and Unified Parkinson's Disease Rating Scale Part II and Part III scores at baseline.

• Other Dementias

Full summary, score breakdown and related studies → Original source