Newest studies

Respite time-use among dementia caregivers

32/100 ✓ Peer-reviewed Caregiving Frontiers in Health Services

Key finding: Respite goal achievement on a given week predicted improvements in participants' ratings of their respite time-use outcomes one week later. +4 more findings

• Caregiving

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Temporal Muscle Thickness as a New Biomarker: Its Association With Alzheimer Pathology and Cognitive Impairment in Chinese Adults

49/100 ✓ Peer-reviewed Brain scans and imaging Journal of Cachexia Sarcopenia and Muscle

Key finding: A decline in TMT was associated with worse cognitive function, increased cerebral tau deposition and impaired functional performance. +4 more findings

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Phenolic Compounds in Exercise Physiology: Dual Role in Oxidative Stress and Recovery Adaptation

47/100 ✓ Peer-reviewed Prevention and risk Food Science & Nutrition

Key finding: Exercise-induced oxidative stress results from the overproduction of reactive oxygen and nitrogen species (ROS/RNS) during intense physical activity, potentially impairing muscle function and recovery. +1 more finding

• Lifestyle
• Brain Biology

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Public health strategies for hepatocellular carcinoma: from risk factors to prevention and control

41/100 ✓ Peer-reviewed Prevention and risk Journal of Liver Cancer

Key finding: Tertiary prevention aims to reduce morbidity and mortality through timely treatment and multidisciplinary care. +4 more findings

• Prevention
• Risk Factors
• Diagnosis

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“I Shouldn’t Have to Drive to the Suburbs”: Grocery Store Access, Transportation, and Food Security in Detroit During the COVID-19 Pandemic

41/100 ✓ Peer-reviewed Risk factors Nutrients

Key finding: Bivariate analyses showed that chain grocery store shoppers reported significantly greater fruit and vegetable intake (2.42 vs. 2.14 times/day for independent grocery store shoppers, p < 0.001) and lower rates of food insecurity compared to independent store shoppers (45.9% vs. 65.3% for independ +4 more findings

• Health Equity

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Evaluating the pragmatic characteristics of advance care planning outcome measures in dementia clinical trials: A scoping review

38/100 ✓ Peer-reviewed End-of-life care Carolina Digital Repository (University of North Carolina at Chapel Hill)

Key finding: Trials included 103 outcome measures (39 primary and 64 secondary), of which 11% measured process, 14% measured action, 49% measured healthcare, and 26% measured quality of care. +4 more findings

• End-of-Life Care
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Assistive technologies for people with advanced disease and in palliative care: a scoping review

32/100 ✓ Peer-reviewed End-of-life care Disability and Rehabilitation Assistive Technology

Key finding: Outcomes of assistive technology use related to functioning, quality of life, dignity in end-of-life care and health service use. +4 more findings

• End-of-Life Care
• Digital Tools

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Understanding rehabilitation and support needs after an episode of delirium: a qualitative thematic analysis of interviews with older people with delirium, family carers and healthcare professionals

40/100 ✓ Peer-reviewed Clinical safety BMC Geriatrics

Key finding: Several interconnected themes were identified as potential resources that enable recovery from delirium: (a) social contact and recovery of social lives; (b) the need for information, support, and education; (c) personalisation and personhood; (d) relationship continuity with professional carers; (e) the experience and involvement of carers; and (f) treating the cause and healthy lifestyle. +2 more findings

• Caregiving

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Can Frontal Assessment Battery Discriminate between Patients with Alzheimer’s and Frontotemporal Dementia?

46/100 ✓ Peer-reviewed Getting a diagnosis Archives of Clinical Neuropsychology

Key finding: FAB-Ch scores were significantly lower in individuals with dementia compared to controls (p < .001). +4 more findings

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“It may cost you your money, it costs you your life”: a framework for financial hardship in dementia

48/100 ✓ Peer-reviewed End-of-life care The Gerontologist

Key finding: Among 52 participants recruited, 27 were former caregivers, 16 were current caregivers, and nine were persons with dementia; experiences reflected Alzheimer's (n = 18), sporadic Creutzfeldt-Jakob (n = 12), Lewy body (n = 7), and other dementias (n = 15). +4 more findings

• Policy

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Co-occurrence of multiple pathologies in a case of frontotemporal dementia with TBK1 mutation: first in vivo detection of alpha-synuclein and tau co-pathology

36/100 ✓ Peer-reviewed Disease mechanisms Acta Neuropathologica Communications

Key finding: Our findings support a broader interpretation of TBK1-associated neurodegeneration and highlight the importance of multimodal diagnostic approaches that integrate molecular, genetic, imaging, and neuropathological tools. +1 more finding

• Genetics
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Co-Expression of Mutant Tau and α-Synuclein in Neurons Promotes Tau Phosphorylation, Neuronal Loss, and Neuroinflammation in Mouse Brain

36/100 ✓ Peer-reviewed Inflammation and the immune system Molecular Neurobiology

Key finding: Previous studies revealed that tau and α-syn promote their aggregation with each other. +3 more findings

• Brain Biology
• Other Dementias

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Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome

41/100 ✓ Peer-reviewed Brain tissue and pathology Acta Neuropathologica Communications

Key finding: Furthermore, we observed a striking difference in the abundance of neuropathological proteins TDP-43 and ANXA11, and their interactors between the temporal cortex and dentate gyrus.

• Brain Biology
• Policy

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Intermittent fasting reprograms the brain proteome to prevent synaptic degeneration and cognitive impairment in vascular dementia

44/100 ✓ Peer-reviewed Lewy body dementia Theranostics

Key finding: These findings establish IF as a potent modulator of synaptic resilience in VaD, acting through coordinated preservation of synaptic structure, inhibition of inflammatory synapse loss, and metabolic reprogramming. +1 more finding

• Other Dementias
• Brain Biology

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Beneficial effect of artificial intelligence care call on memory and depression in community dwelling individuals with dementia

39/100 ✓ Peer-reviewed Digital health tools Scientific Reports

Key finding: After the AI care call intervention, GDS scores decreased significantly, while memory scores increased significantly. +3 more findings

• Digital Tools

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Clinical prediction models using artificial intelligence approaches in dementia

59/100 ✓ Peer-reviewed Digital health tools Aging Clinical and Experimental Research

Key finding: Among 2699 articles initially screened, 21 studies were included, encompassing over 1 million participants. +4 more findings

• Digital Tools

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Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort

50/100 ✓ Peer-reviewed How common it is Alzheimer s Research & Therapy

Key finding: , respectively (p-values < 0.05), with p-tau217 demonstrating the highest classification accuracy for Aβ-PET status (AUC = 0.94). +3 more findings

• Biomarkers

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Equitable formal care access: examining processes for Hispanic/Latino family dementia caregivers’ decision-making

37/100 ✓ Peer-reviewed Caregiving The Gerontologist

Key finding: Four main themes were identified: (1) reasons family caregivers may not choose formal care, (2) perceived benefits of formal care, (3) how family caregivers choose formal care, and (4) recommendations for delivering information about formal care options. +4 more findings

• Caregiving
• Health Equity

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Evaluation of Reminiscence Therapy on Language Outcomes Among People With Dementia

26/100 ✓ Peer-reviewed Getting a diagnosis Perspectives of the ASHA Special Interest Groups

Key finding: There was a significant correlation in MoCA and FLCI-2 measures but no significant correlation between the language measures (CIUs, FLCI-2, or word count). +2 more findings

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Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention

46/100 ✓ Peer-reviewed Prevention and risk Nutrition & Metabolism

Key finding: These findings align with mechanistic evidence on the food-gut-brain axis in maintaining optimal brain health by preventing neurodegeneration. +1 more finding

• Prevention
• Lifestyle
• Brain Biology

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Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases

48/100 ✓ Peer-reviewed Genetics Nature Biotechnology

Key finding: We introduce scPRS, a graph neural network-based framework that computes single-cell-resolved PRSs by integrating reference single-cell chromatin accessibility profiles. scPRS outperforms traditional PRS approaches in genetic risk prediction, as demonstrated across multiple diseases including type 2 diabetes, hypertrophic cardiomyopathy, Alzheimer disease and severe COVID-19.

• Genetics

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Alcohol consumption and cerebrospinal fluid biomarkers for preclinical alzheimer's disease in a population-based sample of 70-year-olds

51/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

Key finding: It is largely unknown how alcohol use affects the risk of Alzheimer`s disease (AD). +3 more findings

• Biomarkers
• Early Stage
• Lifestyle

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No improvement with palliative care in patients with moderate to severe dementia

29/100 ✓ Peer-reviewed End-of-life care AJN American Journal of Nursing

• End-of-Life Care

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The discriminant ability of the Eating Assessment Tool-10 to detect dysphagia and aspiration according to the stage of Alzheimer's disease

39/100 ✓ Peer-reviewed Clinical safety Journal of Alzheimer s Disease

Key finding: BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder frequently associated with dysphagia, leading to malnutrition, dehydration, and aspiration pneumonia. +2 more findings

• Diagnosis

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Multidomain interventions for dementia: Reconsidering clinical relevance, transferability and trial limitations

28/100 ✓ Peer-reviewed Prevention trials Geriatrics and gerontology international/Geriatrics & gerontology international

• Clinical Trials

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