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Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels
Babulal GM, Ghoshal N, Head D, Vernon EK, Holtzman DM, Benzinger TLS, Fagan AM, Morris JC et al.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2016-04-19
Topic: Amyloid, tau and blood-test diagnosis
Objectives To evaluate whether cerebrospinal fluid (CSF) and PET Pittsburgh Compound B (PiB) biomarkers of underlying Alzheimer disease (AD) pathology (β-amyloid 42 [Aβ 42 ], tau, phosphorylated tau 181 [ptau 181 ], tau/Aβ 42 , ptau 181 /Aβ 42 and mean cortical binding potential [MCBP] for PET-PiB) predict changes in mood in cognitively normal older adults. Setting Knight Alzheimer's Disease Research Center (ADRC) at Washington University (WU). Participants Participants, 65 years of age or older, were enrolled from longitudinal studies at the WU Knight ADRC.
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APA 7th
Babulal, G. M., Ghoshal, N., Head, D., Vernon, E. K., Holtzman, D. M., Benzinger, T. L. S., et al. (2016). Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. https://doi.org/10.1016/j.jagp.2016.04.004
Vancouver
Babulal GM, Ghoshal N, Head D, Vernon EK, Holtzman DM, Benzinger TLS, et al. Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2016. doi:10.1016/j.jagp.2016.04.004. PMID: 27426238.
BibTeX
@article{babulal2016-27426238,
author = {Babulal, G. M. and Ghoshal, N. and Head, D. and Vernon, E. K. and Holtzman, D. M. and Benzinger, T. L. S. and Fagan, A. M. and Morris, J. C. and others},
title = {{Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels}},
journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
year = {2016},
doi = {10.1016/j.jagp.2016.04.004},
pmid = {27426238},
url = {https://doi.org/10.1016/j.jagp.2016.04.004}
}
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Key findings
- Setting Knight Alzheimer's Disease Research Center (ADRC) at Washington University (WU).
- Participants Participants, 65 years of age or older, were enrolled from longitudinal studies at the WU Knight ADRC.
- Measurements CSF, PET-PiB biomarkers, Clinical Dementia Rating (CDR), Mini-Mental State Examination (MMSE), Profile of Mood States-Short Form (POMS-SF), the Geriatric Depression Scale (GDS), and Neuropsychiatric Inventory Questionnaire (NPI-Q).
- Results Data from 118 participants at baseline and 66 participants at one-year follow-up were analyzed.
Why it matters
This study examined whether Alzheimer's disease biomarkers in spinal fluid and brain scans predict mood changes in cognitively normal older adults. It is about a possible link between biomarkers and mood, not about treating, curing or preventing the disease.
Study details
- Study designlongitudinal study
- Participants118
- Evidence strengthModerate
How this study scored 58/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry) |
| Journal's citation record | 2 / 4 | American Journal of Geriatric Psychiatry: journal h-index 178 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 118 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 143 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.9 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 3 / 6 | Cited 7.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 2 / 4 | Cited 47 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Catherine M. Roe: h-index 51 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27426238) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
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