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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 13,626–13,650 of 27,380 studies, newest first · page 546 of 1096.

September 2018 25

  1. 2018-09-29

    Concordance Between Proxy Level of Care Preference and Advance Directives Among Nursing Home Residents With Advanced Dementia: A Cluster Randomized Clinical Trial

    ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

    Key finding: Better alignment between preferences for comfort-focused care and advance directives is needed in advanced dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2018-09-28

    DYRK1A and cognition: A lifelong relationship

    ✓ Peer-reviewed Down syndrome and Alzheimer's Pharmacology & therapeutics

    Key finding: Because this kinase is positioned at the crossroads of many important processes, genetic dosage errors in this protein produce devastating effects arising from DYRK1A deficiency, such as in MRD7, an autism spectrum disorder, or from DYRK1A excess, such as in Down syndrome. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2018-09-28

    Fluoride activates microglia, secretes inflammatory factors and influences synaptic neuron plasticity in the hippocampus of rats

    ✓ Peer-reviewed TREM2 and immune genetics Neurotoxicology

    Key finding: It is thought that synaptic plasticity is the basis of learning and memory skills in developing children. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2018-09-27

    MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study

    ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy

    Key finding: Amyloid pathology is associated with changes in structural MRI measures in CN and MCI. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2018-09-27

    Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice

    ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: Better cognitive outcome and higher synaptic density in PS2APP mice was predicted by higher TSPO expression at 8 mo. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2018-09-26

    The efficacy and safety of memantine for the treatment of Alzheimer's disease

    ✓ Peer-reviewed Treatments Expert opinion on drug safety

    Key finding: Although memantine monotherapy and combination therapy are associated with a few individual adverse events such as somnolence, it is well-tolerated and its safety (all-cause discontinuation) is comparable or superior to that of the placebo (agitation).

    Full summary, score breakdown and related studies → Original source

  7. 2018-09-26

    Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics European journal of human genetics : EJHG

    Key finding: We hypothesized that variant effect sizes should increase when individuals who represent the extreme ends of a disease spectrum are considered, as their genomes are assumed to be maximally enriched or depleted with disease-associated genetic variants. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2018-09-26

    Microglia in neurodegeneration

    ✓ Peer-reviewed Lewy body dementia Nature neuroscience

    Key finding: Injury to neurons in Alzheimer's, Parkinson's, Huntington's, and prion diseases, as well as in amyotrophic lateral sclerosis, frontotemporal dementia, and chronic traumatic encephalopathy, results from disruption of the sentinel or housekeeping functions and dysregulation of the defense function and neuroinflammation. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2018-09-25

    The intestinal microbiome and Alzheimer's disease: A review

    ✓ Peer-reviewed Disease mechanisms Animal models and experimental medicine

    Key finding: Alzheimer's disease (AD) is an increasingly common neurodegenerative disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2018-09-25

    Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease

    ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

    Key finding: Three biomarkers were identified to differ among the AD stages, including neurofilament light chain (NfL; p < 0.001), fatty acid binding protein 3 (Fabp3; p < 0.001), and interleukin (IL)-10 (p = 0.033). +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2018-09-25

    Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia

    ✓ Peer-reviewed Biomarkers PloS one

    Key finding: Among the hip fracture patients, 88.6% of the cognitively normal (Clinical Dementia Rating-CDR 0; n = 70) and 98.8% with mild cognitive impairment (CDR 0.5; n = 81) fell in the abnormal biomarker categories by the A/T/N classification. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2018-09-25

    Neurotoxic effects of organophosphorus pesticides and possible association with neurodegenerative diseases in man: A review

    ✓ Peer-reviewed Risk factors Toxicology

    Key finding: Compared to the cholinergic syndrome, that causes millions of cases of poisoning with fatality of more than 15% each year, other disorders involve much smaller number of patients.

    Full summary, score breakdown and related studies → Original source

  13. 2018-09-25

    Cerebral Small Vessel Disease

    ✓ Peer-reviewed Vascular contributions Cell transplantation

    Key finding: Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological processes and etiologies. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2018-09-25

    Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model

    ✓ Peer-reviewed Inflammation and the immune system Nature communications

    Key finding: An inflammatory neurodegenerative pathway, involving Caspase-1 activation, is associated with human age-dependent cognitive impairment and several classical AD brain pathologies. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2018-09-25

    Aging and the Epidemiology of Epilepsy

    ✓ Peer-reviewed Caregiving Neuroepidemiology

    Key finding: The increased incidence of seizures and epilepsy in the elderly can be attributed to the increase of age-related and aging-related epileptogenic conditions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2018-09-24

    High Burden of Palliative Care Needs of Older Adults During Emergency Major Abdominal Surgery

    ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

    Key finding: Of 411 participants, 57% had high illness burden. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2018-09-24

    Steroid-responsive encephalopathy with a peculiar CSF biomarker profile in an 89-year-old man

    ✓ Peer-reviewed Tau biomarkers Oxford medical case reports

    Key finding: Being treatable, steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), or Hashimoto's encephalopathy, should be distinguished from untreatable conditions.

    Full summary, score breakdown and related studies → Original source

  18. 2018-09-24

    The role of brain vasculature in neurodegenerative disorders

    ✓ Peer-reviewed Vascular contributions Nature neuroscience

    Key finding: On the other hand, cerebral blood flow shortfalls and blood-brain barrier dysfunction are early findings in neurodegenerative disorders in humans and animal models. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2018-09-24

    Interventions for hearing and vision impairment to improve outcomes for people with dementia: a scoping review

    ✓ Peer-reviewed Risk factors International psychogeriatrics

    Key finding: ABSTRACTBackground:Age-related hearing and vision problems are common among people with dementia and are associated with poorer function, reduced quality of life and increased caregiver burden. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2018-09-24

    Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development

    ✓ Peer-reviewed Long-term cohort studies Frontiers in genetics

    Key finding: Although genome-wide association study (GWAS) have reported hundreds of single-nucleotide polymorphisms (SNPs) and genes linked to AD, the mechanisms about how these SNPs modulate the development of AD remain largely unknown. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2018-09-24

    Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial

    ✓ Peer-reviewed Cognitive tests and assessment PLoS medicine

    Key finding: This study reports the findings of the first large-scale Phase III investigator-driven clinical trial to slow the rate of cognitive decline in Alzheimer disease with a dihydropyridine (DHP) calcium channel blocker, nilvadipine. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2018-09-24

    Animal models of neurodegenerative diseases

    ✓ Peer-reviewed Lewy body dementia Nature neuroscience

    Key finding: Animal models of adult-onset neurodegenerative diseases have enhanced the understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2018-09-24

    American Geriatrics Society and National Institute on Aging Bench-to-Bedside Conference: Sensory Impairment and Cognitive Decline in Older Adults

    ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society

    Key finding: Comorbid vision, hearing, and cognitive impairments in older adults are more common than would be expected by chance alone, suggesting that some common mechanisms might affect these neurological systems.

    Full summary, score breakdown and related studies → Original source

  24. 2018-09-24

    Procedural Framework to Facilitate Hospital-Based Informed Consent for Dementia Research

    ✓ Peer-reviewed Treatments Journal of the American Geriatrics Society

    Key finding: Short stays; limited access to patients, caregivers, and LARs; and fluctuating influences of acute illness on capacity determination compound these challenges in the acute care setting. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2018-09-24

    The effect of reminiscence therapy on cognitive functions, depression, and quality of life in Alzheimer patients: Randomized controlled trial

    ✓ Peer-reviewed Treatments International journal of geriatric psychiatry

    Key finding: Alzheimer is a disease leading to various neuropsychiatric behavioral disorders, and the most common symptom observed during the prognosis of Alzheimer's disease is dysmnesia.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →