Newest studies

Microglial activation and tau propagate jointly across Braak stages

77/100 ✓ Peer-reviewed TREM2 and immune genetics Nature medicine

Key finding: We tested the hypothesis that the spatial propagation of microglial activation and tau accumulation colocalize in a Braak-like pattern in the living human brain. +3 more findings

• Brain Biology

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Role of Oxidative Damage in Alzheimer's Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery

49/100 ✓ Peer-reviewed Mild cognitive impairment Antioxidants (Basel, Switzerland)

Key finding: Oxidative damage is involved in the molecular mechanisms which link the accumulation of amyloid-β and neurofibrillary tangles, containing hyperphosphorylated tau, to microglia response. +4 more findings

• Early Stage
• Biomarkers
• Brain Biology

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Cognitive Trajectories and Dementia Risk: A Comparison of Two Cognitive Reserve Measures

41/100 ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience

Key finding: Both reserve measures were associated with cognitive trajectories [β × time (top tertile, ref.: bottom tertile) = 0.013; 95% CI: -0.126, -0.004 (residual-based) and 0.011; 95% CI: -0.001, 0.024, (activity-based)]. +4 more findings

• Risk Factors

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Pretreatment with metformin prevents microcystin-LR-induced tau hyperphosphorylation via mTOR-dependent PP2A and GSK-3β activation

41/100 ✓ Peer-reviewed Drug development Environmental toxicology

Key finding: A previous study indicated that tau protein hyperphosphorylation via protein phosphatase 2A (PP2A) and GSK-3β inhibition was the mechanism by which MC-LR induces neurotoxicity; however, how MC-LR-induced neurotoxicity can be effectively prevented remains unclear. +2 more findings

• Prevention

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Altered Cerebellar Resting-State Functional Connectivity in Early-Stage Parkinson's Disease Patients With Cognitive Impairment

48/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in neurology

Key finding: Compared to healthy control subjects with no cognitive deficits, altered cerebellar FC were observed in early PD participants with both motor and cognitive deficits, but not in PD patients with normal cognition, nor elderly subjects showing signs of a cognitive impairment. +3 more findings

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Psychological and Emotional Effects of Digital Technology on Children in COVID-19 Pandemic

47/100 ✓ Peer-reviewed Cognitive tests and assessment Brain sciences

Key finding: The overall documented percentage increase of technology usage in children was about 15%, of which smartphone usage has 61.7% of prevalence.

• Digital Tools

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Mass spectrometry-based methods for robust measurement of Alzheimer's disease biomarkers in biological fluids

40/100 ✓ Peer-reviewed Biomarkers Journal of neurochemistry

Key finding: Recently, technological advancements in protein detection made possible the effective study of plasma AD biomarkers despite their significantly lower concentrations versus to that in CSF.

• Biomarkers

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Evaluation of [18F]PI-2620, a second-generation selective tau tracer, for assessing four-repeat tauopathies

45/100 ✓ Peer-reviewed Brain scans and imaging Brain communications

Key finding: To assess the ability of [18F]PI-2620 to detect regional tau burden in non-Alzheimer's disease tauopathies compared with Alzheimer's disease, patients with progressive supranuclear palsy (n = 3), corticobasal syndrome (n = 2), corticobasal degeneration (n = 1) or Alzheimer's disease (n = 8), and healthy controls (n = 7) were recruited. +4 more findings

• Brain Scans

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Differential interaction with TREM2 modulates microglial uptake of modified Aβ species

41/100 ✓ Peer-reviewed TREM2 and immune genetics Glia

Key finding: Rare coding variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2) confer an increased risk for Alzheimer's disease (AD) characterized by the progressive accumulation of aggregated forms of amyloid β peptides (Aβ). +2 more findings

• Brain Biology
• Genetics

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Dementia Care in Diverse Older Adults in the U.S. Deep South and the Rest of the United States

38/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

Key finding: Across racial/ethnic groups, 33%-43% in DS and 43%-50% in non-DS used specialists; 47%-55% in DS and 41%-48% in non-DS used ADRD drugs. +4 more findings

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The Mediterranean diet and health: a comprehensive overview

40/100 ✓ Peer-reviewed Risk factors Journal of internal medicine

Key finding: The Mediterranean diet (MedDiet), one of the most studied and well-known dietary patterns worldwide, has been associated with a wide range of benefits for health. +2 more findings

• Lifestyle
• Risk Factors

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Cellular and pathological heterogeneity of primary tauopathies

43/100 ✓ Peer-reviewed Genetics Molecular neurodegeneration

Key finding: Multiple studies have suggested that pathological tau species may act as a seed that promotes aggregation of endogenous tau in naïve cells and contributes to propagation of tau pathology.

• Brain Biology

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TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination

54/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of experimental medicine

Key finding: Whereas the essential phagocytic function of microglia for remyelination is well known, the underlying metabolic pathways required for myelin debris clearance are poorly understood. +3 more findings

• Genetics

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The Central Mechanisms of Resistance Training and Its Effects on Cognitive Function

41/100 ✓ Peer-reviewed Prevention trials Sports medicine (Auckland, N.Z.)

Key finding: While the benefits of resistance exercise on the neuromuscular system are well documented, there is growing evidence to suggest that resistance exercise, even when performed acutely, can lead to neuroplastic changes within the central nervous system (CNS) and improve cognitive functioning.

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Nursing Home Alzheimer's Special Care Units: Geographic Location Matters

44/100 ✓ Peer-reviewed Risk factors Journal of the American Medical Directors Association

Key finding: We examined locations of NHs with ASCUs and assessed whether neighborhood socioeconomic deprivation, region, and levels of rurality were associated with NH ASCUs. +4 more findings

• Care Services

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Neuropsychiatric and Cognitive Symptoms Across the Alzheimer Disease Clinical Spectrum: Cross-sectional and Longitudinal Associations

69/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology

Key finding: In this single-center observational study, we included all individuals who visited the Alzheimer Center Amsterdam and had a clinical diagnosis of subjective cognitive decline (SCD), mild cognitive impairment (MCI), or probable AD dementia and were A+. +3 more findings

• Early Stage

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The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy

48/100 ✓ Peer-reviewed Risk genes beyond APOE Autophagy

Key finding: This novel group of human disorders may present throughout life and comprises severe early-onset neurodevelopmental and more common adult-onset neurodegenerative disorders. +3 more findings

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Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease

41/100 ✓ Peer-reviewed Vascular contributions Metabolic brain disease

Key finding: Further research is required to better understand the early pathophysiological mechanisms associated with NVU alteration and CAA to generate early biomarkers and timely treatments for AD.

• Brain Biology

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Planning and optimising a digital intervention to protect older adults' cognitive health

43/100 ✓ Peer-reviewed Prevention trials Pilot and feasibility studies

Key finding: A digitally delivered intervention with minimal support appears acceptable and potentially engaging to older adults with higher and lower levels of cognitive performance. +2 more findings

• Digital Tools

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Feasibility of Routine Quality of Life Measurement for People Living With Dementia in Long-Term Care

48/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Medical Directors Association

Key finding: Average time to complete DEMQOL-CH was <5 minutes. +4 more findings

• Care Services

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Risk factors for postoperative delirium: An umbrella review of systematic reviews

60/100 ✓ Peer-reviewed Clinical safety International journal of surgery (London, England)

Key finding: Given the wealth of existing literature, future research should avoid simple risk factor evaluation except for novel candidates, validate existing prognostic models where possible, and instead focus on interventional research. +2 more findings

• Risk Factors

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Higher circulating α-carotene was associated with better cognitive function: an evaluation among the MIND trial participants

76/100 ✓ Peer-reviewed Prevention trials Journal of nutritional science

Key finding: High plasma α-carotene was associated with better global cognition. +4 more findings

• Clinical Trials
• Lifestyle

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Delirium in critical illness: clinical manifestations, outcomes, and management

67/100 ✓ Peer-reviewed Risk factors Intensive care medicine

Key finding: Now it is known that antipsychotics and other psychoactive medications do not reliably improve brain function in critically ill delirious patients. +4 more findings

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Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial

58/100 ✓ Peer-reviewed Treatments Neurology and therapy

Key finding: These results indicate that trans-resveratrol has potential neuroprotective roles in the treatment of moderate to mild AD and that its mechanism may involve a reduction in the accumulation and toxicity of Aβ in the brain of patients, thereby reducing neuroinflammation. +3 more findings

• Clinical Trials
• Biomarkers
• Brain Scans

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Multimodal retinal imaging to detect and understand Alzheimer's and Parkinson's disease

41/100 ✓ Peer-reviewed Brain scans and imaging Current opinion in neurobiology

Key finding: It makes the retina not only a promising target for biomarker development, but it also suggests that novel fundamental insights into the pathophysiology of Alzheimer's and Parkinson's disease can be obtained by studying the retina-brain axis.

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source