Newest studies

Initiating advance care planning on end-of-life issues in dementia: Ambiguity among UK and Dutch physicians

47/100 ✓ Peer-reviewed End-of-life care Archives of gerontology and geriatrics

Key finding: There is considerable ambiguity about initiating ACP in dementia at diagnosis among physicians practicing in two different European health care systems and caring for different patient populations. +1 more finding

• End-of-Life Care

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Dementia in Down's syndrome

51/100 ✓ Peer-reviewed Brain tissue and pathology The Lancet. Neurology

Key finding: Genetic drivers result in a high frequency of Alzheimer's pathology in these individuals, evident from neuroimaging, biomarker, and neuropathological findings, and a high incidence of cognitive decline and dementia. +3 more findings

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease

53/100 ✓ Peer-reviewed Getting a diagnosis Acta neuropathologica

Key finding: Recent observations suggest that there is a vascular basis for neuronal atrophy in both the temporal and frontal lobes in VaD that is entirely independent of any Alzheimer pathology. +1 more finding

• Diagnosis
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

The Effects of Cognitive Training for Elderly: Results from My Mind Project

72/100 ✓ Peer-reviewed Prevention trials Rejuvenation research

Key finding: In the three groups, immediately after the end of the intervention, we observed a significant effect on some cognitive and noncognitive outcomes in the EGs. +4 more findings

• Lifestyle

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Green-Fluorescent Protein(+) Astrocytes Attach to Beta-Amyloid Plaques in an Alzheimer Mouse Model and Are Sensitive for Clasmatodendrosis

37/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: Three-dimensional confocal microscopy revealed a tight association and intense sprouting of astrocytic finely branched processes towards Aβ plaques in 12 month old mice. +1 more finding

• Brain Biology

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CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

81/100 ✓ Peer-reviewed Biomarkers The Lancet. Neurology

Key finding: The core biomarkers differentiated Alzheimer's disease from controls with good performance: CSF T-tau (average ratio 2·54, 95% CI 2·44-2·64, p<0·0001), P-tau (1·88, 1·79-1·97, p<0·0001), and Aβ42 (0·56, 0·55-0·58, p<0·0001). +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Prevalence of Intracranial Atherosclerotic Stenosis Using High-Resolution Magnetic Resonance Angiography in the General Population: The Atherosclerosis Risk in Communities Study

52/100 ✓ Peer-reviewed Disparities Stroke

Key finding: The prevalence of ICAS in older adults is high, and it could be a target for primary prevention of stroke and dementia in this population. +2 more findings

• Brain Scans
• Risk Factors

Full summary, score breakdown and related studies → Original source

Safety and tolerability of BAN2401--a clinical study in Alzheimer's disease with a protofibril selective Aβ antibody

66/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy

Key finding: BAN2401 was well-tolerated across all doses. +1 more finding

• Treatments
• Side Effects
• Clinical Trials

Full summary, score breakdown and related studies → Original source

There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS

36/100 ✓ Peer-reviewed Clinical safety Brain research

Key finding: Three major hypotheses have emerged and are still being hotly debated in the field. +4 more findings

• Genetics

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The 2015 Dutch food-based dietary guidelines

62/100 ✓ Peer-reviewed Risk factors European journal of clinical nutrition

Key finding: A general guideline to eat a more plant food-based dietary pattern and limit consumption of animal-based food and 15 specific guidelines have been formulated. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Randomized, Double-Blind, Placebo-Controlled Studies to Evaluate Treatment with Aducanumab (BIIB037) in Patients with Early Alzheimer’s Disease: Phase 3 Study Design (S1.003)

48/100 ✓ Peer-reviewed Treatments Neurology

Key finding: ENGAGE and EMERGE are Phase 3 clinical trials designed to confirm the clinical efficacy and safety profile of aducanumab in individuals with Early AD.

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

PICALM rs3851179 Variant Confers Susceptibility to Alzheimer's Disease in Chinese Population

68/100 ✓ Peer-reviewed Genetics Molecular neurobiology

Key finding: However, these studies reported consistent and inconsistent results. +4 more findings

• Genetics

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Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)

57/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: People's differences in cognitive functions are partly heritable and are associated with important life outcomes. +4 more findings

• Genetics

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Dopa-responsive akinesia: Homozygous GCH1 mutation (P5.150)

31/100 ✓ Peer-reviewed Health systems and care delivery Neurology

Key finding: This individual had childhood-onset progressive motor impairment. +4 more findings

• Genetics

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TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus

44/100 ✓ Peer-reviewed TREM2 and immune genetics Clinical epigenetics

Key finding: Recent genome-wide association studies revealed TREM2 rs75932628-T variant to be associated with Alzheimer's disease (AD) and other neurodegenerative diseases. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns

57/100 ✓ Peer-reviewed Genetics Translational psychiatry

Key finding: We systematically compared structural imaging patterns of advanced brain aging (ABA) in the general-population, herein defined as significant deviation from typical BA to those found in Alzheimer disease (AD). +4 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Ensembles of Deep Learning Architectures for the Early Diagnosis of the Alzheimer's Disease

36/100 ✓ Peer-reviewed Digital health tools International journal of neural systems

Key finding: Two deep learning based structures and four different voting schemes are implemented and compared, giving as a result a potent classification architecture where discriminative features are computed in an unsupervised fashion. +1 more finding

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Association Between Oral Health and Cognitive Status: A Systematic Review

60/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society

Key finding: It is unclear how or whether oral health and cognitive status are related. +1 more finding

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The Effect of Decreased Audibility on MMSE Performance: A Measure Commonly Used for Diagnosing Dementia

71/100 ✓ Peer-reviewed Risk factors Journal of the American Academy of Audiology

Key finding: Apparent cognitive deficits based on MMSE scores obtained in test conditions in which audibility is reduced could result in incorrectly identified cognitive loss if clinicians are not alert to hearing loss when patients are evaluated. +1 more finding

• Diagnosis

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Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides

40/100 ✓ Peer-reviewed Drug development EMBO molecular medicine

Key finding: These results reveal an association between ApoER2 isoform expression and AD, and provide preclinical evidence for the utility of ASOs as a therapeutic approach to mitigate Alzheimer's disease symptoms by improving ApoER2 exon 19 splicing.

• Treatments
• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia

36/100 ✓ Peer-reviewed Brain scans and imaging Continuum (Minneapolis, Minn.)

Key finding: This article provides an overview of the clinical features, neuropathologic findings, diagnostic criteria, and management of dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD), together known as the Lewy body dementias.

• Other Dementias
• Brain Scans

Full summary, score breakdown and related studies → Original source

Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions

55/100 ✓ Peer-reviewed Brain scans and imaging The Lancet. Neurology

Key finding: Idiopathic rapid eye movement (REM) sleep behaviour disorder (IRBD) manifests as unpleasant dreams and vigorous behaviours during REM sleep that can result in injuries.

• Diagnosis
• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source

Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial

75/100 ✓ Peer-reviewed Clinical safety JAMA

Key finding: Among patients with agitated delirium receiving mechanical ventilation in the intensive care unit, the addition of dexmedetomidine to standard care compared with standard care alone (placebo) resulted in more ventilator-free hours at 7 days. +4 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Adjuvant transcranial direct current stimulation for treating Alzheimer's disease: A case study

45/100 ✓ Peer-reviewed Prevention trials Dementia & neuropsychologia

Key finding: The data obtained revealed that the application of tDCS had a stabilizing effect on overall patient cognitive function and led to improved performance on all the secondary outcome tests. +1 more finding

• Treatments

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Effect of Potentially Inappropriate Use of Antimuscarinic Medications on Healthcare Use and Cost in Individuals with Overactive Bladder

41/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: Of members initiated on an antimuscarinic OAB medication, 31.1% had a drug-drug or drug-disease or syndrome interaction. +4 more findings

• Treatments
• Policy

Full summary, score breakdown and related studies → Original source