Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 22,376–22,400 of 27,380 studies, newest first · page 896 of 1096.
November 2007 5
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2007-11-01
An alternative method for estimating efficacy of the AN1792 vaccine for Alzheimer disease
54/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Published results from the AN1792 trial may have underestimated the effect of vaccine on progression of cerebral atrophy among patients with an antibody response to the vaccine. +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-11-01
Donepezil treatment and Alzheimer disease: can the results of randomized clinical trials be applied to Alzheimer disease patients in clinical practice?
47/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: A comparison of a randomized clinical trial of donepezil in AD patients and this observational study indicates that if appropriate methodological and statistical precautions are undertaken, then results from randomized clinical trials can be predictive with AD patients in clinical practice. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-11-01
Cost-benefit analysis of second-generation antipsychotics and placebo in a randomized trial of the treatment of psychosis and aggression in Alzheimer disease
64/100 ✓ Peer-reviewed Treatments Archives of general psychiatry
Key finding: There were no differences in measures of effectiveness between initiation of active treatments or placebo (which represented watchful waiting) but the placebo group had significantly lower health care costs. +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-11-01
Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials
62/100 ✓ Peer-reviewed Treatments PLoS medicine
Key finding: No significant differences emerged in the probability of conversion from MCI to AD or dementia between the treated groups and the placebo groups. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-11-01
Dietary patterns and risk of dementia: the Three-City cohort study
72/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Frequent consumption of fruits and vegetables, fish, and omega-3 rich oils may decrease the risk of dementia and Alzheimer disease, especially among ApoE epsilon 4 noncarriers. +3 more findings
Full summary, score breakdown and related studies → Original source
October 2007 20
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2007-10-29
Prevalence of dementia in the United States: the aging, demographics, and memory study
62/100 ✓ Peer-reviewed Getting a diagnosis Neuroepidemiology
Key finding: Dementia prevalence estimates from this first nationally representative population-based study of dementia in the USA to include subjects from all regions of the country can provide essential information for effective planning for the impending healthcare needs of the large and increasing number of individuals at risk for dementia as our population ages.
Full summary, score breakdown and related studies → Original source
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2007-10-25
Cognitive training for persons with mild cognitive impairment
64/100 ✓ Peer-reviewed Prevention trials International psychogeriatrics
Key finding: Furthermore, a large-scale randomized control trial with older adults, independent at entry, indicated that training delayed their cognitive and functional decline over a five-year follow-up. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-10-25
Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies
49/100 ✓ Peer-reviewed How common it is Brain research
Key finding: The amygdala and hippocampus that were vulnerable to tau or alpha-synuclein pathology demonstrated more severe TDP-43 pathology in AD and DLB cases than in FTLD-U cases. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-10-25
Chronic kidney disease is associated with white matter hyperintensity volume: the Northern Manhattan Study (NOMAS)
54/100 ✓ Peer-reviewed Prevention and risk Stroke
Key finding: The association between moderate-severe chronic kidney disease and white matter hyperintensity volume highlights the growing importance of kidney disease as a possible determinant of cerebrovascular disease and/or as a marker of microangiopathy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-10-24
Parkinson's disease: a dual-hit hypothesis
36/100 ✓ Peer-reviewed Mild cognitive impairment Neuropathology and applied neurobiology
Key finding: Accumulating evidence suggests that sporadic Parkinson's disease has a long prodromal period during which several non-motor features develop, in particular, impairment of olfaction, vagal dysfunction and sleep disorder. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-10-24
The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
52/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: The results showed that age by epsilon4 genotype interactions were found for P-tau231 (beta=1.82; p<0.05) and IP (beta=1.6; p<0.05). +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-10-24
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation
47/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Gamma-secretase can be blocked by selective inhibitors but can also be modulated by a subset of non-steroidal anti-inflammatory drugs, including sulindac sulfide. +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-10-24
Senile myoclonic epilepsy of Genton: two cases in Down syndrome with dementia and late onset epilepsy
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Epilepsy research
Key finding: Senile myoclonic epilepsy of Genton is a newer epileptic syndrome of the older patients with Down syndrome associated with an Alzheimer-type dementia.
Full summary, score breakdown and related studies → Original source
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2007-10-22
The Rotterdam Study: objectives and design update
51/100 ✓ Peer-reviewed Long-term cohort studies European Journal of Epidemiology
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands.
Full summary, score breakdown and related studies → Original source
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2007-10-22
BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein
40/100 ✓ Peer-reviewed Tau biomarkers The Journal of biological chemistry
Key finding: Research into possible mechanisms leading to the accumulation of modified Tau protein and the possibility of removing Tau protein from the system have revealed that the chaperone protein system can interact with Tau and mediate its degradation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-10-22
Gene expression profiling in the adult Down syndrome brain
50/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Genomics
Key finding: The unique profile of up-regulation on chromosome 21, consistent with primary dosage effects, was accompanied by widespread transcriptional disruption. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-10-18
Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of physiology
Key finding: Clinical manifestations result from selective neuronal degeneration of predominantly GABAergic striatal medium-sized spiny neurons (MSNs). +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-10-17
Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
47/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: Compelling evidence indicates that excess consumption of sugar-sweetened beverages plays an important role in the epidemic of obesity, a major risk factor for type 2 diabetes mellitus. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-10-16
Adjusted-Dose Warfarin versus Aspirin for Preventing Stroke in Patients with Atrial Fibrillation
76/100 ✓ Peer-reviewed Costs and economics Annals of Internal Medicine
Key finding: Letters16 October 2007Adjusted-Dose Warfarin versus Aspirin for Preventing Stroke in Patients with Atrial FibrillationRobert G. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-10-14
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2007-10-09
Peripheral inflammatory cytokines as biomarkers in Alzheimer's disease and mild cognitive impairment
40/100 ✓ Peer-reviewed Mild cognitive impairment Neuro-degenerative diseases
Key finding: These results agree with a persistent inflammatory status in AD, reinforcing the hypothesis of a progressive impairment of the immune response in this disorder and suggesting that monocytes may be good targets to study the progression from MCI to AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-10-04
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds
40/100 ✓ Peer-reviewed Risk genes beyond APOE Bioorganic & medicinal chemistry letters
Key finding: To this aim we designed, synthesized, and tested a series of compounds by introducing halophenylalkylamidic functions on the scaffold of AP2238, which is a dual binding site acetylcholinesterase inhibitor. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-10-03
The hemo-neural hypothesis: on the role of blood flow in information processing
36/100 ✓ Peer-reviewed Vascular contributions Journal of neurophysiology
Key finding: This novel view of information processing-that includes hemodynamics as an active and significant participant-has implications for understanding neural representation and the construction of accurate brain models.
Full summary, score breakdown and related studies → Original source
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2007-10-01
Fragile X-associated tremor/ataxia syndrome: clinical features, genetics, and testing guidelines
36/100 ✓ Peer-reviewed Digital health tools Movement disorders : official journal of the Movement Disorder Society
Key finding: FXTAS is caused by moderate expansions (55-200 repeats; premutation range) of a CGG trinucleotide in the fragile X mental retardation 1 (FMR1) gene, the same gene which causes fragile X syndrome when in the full mutation range (200 or greater CGG repeats). +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-10-01
Donepezil for the treatment of agitation in Alzheimer's disease
74/100 ✓ Peer-reviewed Treatments The New England journal of medicine
Key finding: In this 12-week trial, donepezil was not more effective than placebo in treating agitation in patients with Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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