Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,501–15,525 of 27,380 studies, newest first · page 621 of 1096.
January 2017 25
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2017-01-01
Cognitive Training Interventions for Patients with Alzheimer's Disease: A Systematic Review
66/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: Despite some positive findings, the inaccurate definitions of CT, inadequate sample sizes, unclear randomization methods, incomplete datasets at follow-up and multiple testing may have inflated the results in many trials. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-01-01
Multimodal Cognitive Enhancement Therapy for Patients with Mild Cognitive Impairment and Mild Dementia: A Multi- Center, Randomized, Controlled, Double-Blind, Crossover Trial
72/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: Mini-Mental State Examination (effect size = 0.47, p = 0.013) and Alzheimer's Disease Assessment Scale-Cognitive Subscale (effect size = 0.35, p = 0.045) scores were significantly improved in the MCET compared with mock-therapy group. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-01-01
Tailored and Adaptive Computerized Cognitive Training in Older Adults at Risk for Dementia: A Randomized Controlled Trial
72/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: Home-based CCT with adaptive difficulty and personal tailoring appears superior to more generic CCT in relation to both cognitive and non-cognitive outcomes.
Full summary, score breakdown and related studies → Original source
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2017-01-01
Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway
38/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: Stressful life events were associated with reduced BDNF and increased 3-HK. 3-HK decreased after cognitive training, while BDNF tended to increase after physical training. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-01-01
Synaptic Plasticity, Dementia and Alzheimer Disease
38/100 ✓ Peer-reviewed Disease mechanisms CNS & neurological disorders drug targets
Key finding: We will consider also emerging data dealing with potential therapeutic approaches for ameliorating the cognitive and memory deficits associated with these disorders.
Full summary, score breakdown and related studies → Original source
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2017-01-01
Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies
47/100 ✓ Peer-reviewed Disease mechanisms Annals of neurology
Key finding: AV-1451 may have limited utility for in vivo selective and reliable detection of tau aggregates in these non-Alzheimer tauopathies. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases
41/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Alzheimer's disease : JAD
Key finding: However, evidence suggests that smaller soluble aggregates, called oligomers, are the most toxic species and form prior to tangles. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Neurotoxic reactive astrocytes are induced by activated microglia
68/100 ✓ Peer-reviewed Inflammation and the immune system Nature
Key finding: A subtype of reactive astrocytes, which we termed A1, is induced by classically activated neuroinflammatory microglia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Qualitative Assessment of Verbal Fluency Performance in Frontotemporal Dementia
54/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia and Geriatric Cognitive Disorders
Key finding: Interrater reliability was high (median 0.98). +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
The Determinants of Quality of Life of Nursing Home Residents with Young-Onset Dementia and the Differences between Dementia Subtypes
56/100 ✓ Peer-reviewed Caregiving Dementia and Geriatric Cognitive Disorders
Key finding: Residents' QoL was negatively associated with advanced dementia, PDU, and NPS. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017 no date recorded — placed by publication year
Alzheimer Europe Publication Highlights Inequalities in Access to Dementia Care and Treatment Across Europe
24/100 ✓ Peer-reviewed Risk factors European Neurological Review
Key finding: The objective of a new report, ‘European Dementia Monitor 2017: comparing and benchmarking national dementia strategies and policies’, is to provide a benchmark of national dementia policies in order to compare the responses of European countries to the dementia challenge in different domains. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate
54/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Nevertheless, there has been controversy about what types of oligomers actually confer these AD-like phenotypes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis
73/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Alzheimer's disease : JAD
Key finding: Cohort studies have reported that midlife high total serum cholesterol (TC) is associated with increased risk of Alzheimer's disease (AD) in late-life but findings have been based on few studies and previous reviews have been limited by a lack of compatible data. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Risk Factors and Pathological Substrates Associated with Agitation/Aggression in Alzheimer's Disease: A Preliminary Study using NACC Data
50/100 ✓ Peer-reviewed Long-term cohort studies Journal of Alzheimer's disease : JAD
Key finding: Neuropsychiatric symptoms are common manifestations of Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Plasma Amyloid-β Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study
65/100 ✓ Peer-reviewed Long-term cohort studies Journal of Alzheimer's disease : JAD
Key finding: Plasma amyloid-β (Aβ) levels are increasingly studied as a potential, accessible marker of cognitive impairment and dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Vitamin D and the Risk of Dementia: The Rotterdam Study
58/100 ✓ Peer-reviewed Long-term cohort studies Journal of Alzheimer's disease : JAD
Key finding: Vitamin D has gained interest as a potentially modifiable risk factor for dementia because of its putative neuroprotective effects. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Late-Life Body Mass Index, Rapid Weight Loss, Apolipoprotein E ε4 and the Risk of Cognitive Decline and Incident Dementia
58/100 ✓ Peer-reviewed Long-term cohort studies The journal of nutrition, health & aging
Key finding: Prospective longitudinal cohort study. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Does the Female Advantage in Verbal Memory Contribute to Underestimating Alzheimer's Disease Pathology in Women versus Men?
52/100 ✓ Peer-reviewed Long-term cohort studies Journal of Alzheimer's disease : JAD
Key finding: Females show an advantage over males on tests of verbal memory, which are used to diagnose AD and its precursor, amnestic mild cognitive impairment (aMCI). +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Optical Coherence Tomography Reveals Retinal Neuroaxonal Thinning in Frontotemporal Dementia as in Alzheimer's Disease
49/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD
Key finding: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are leading causes of cognitive decline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
The Montreal Cognitive Assessment: Normative Data from a Large Swedish Population-Based Cohort
55/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD
Key finding: The Montreal Cognitive Assessment (MoCA) has a high sensitivity for detecting cognitive dysfunction. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea
44/100 ✓ Peer-reviewed Tau biomarkers Alzheimer disease and associated disorders
Key finding: Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model
45/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of Alzheimer's disease : JAD
Key finding: Recently, a rare mutation in the gene Triggering receptor expressed on myeloid cells 2 (TREM2) has been associated with a substantial increase in the risk of developing late onset AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
55/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Understanding TREM2 function promises to provide important insights into how neuroinflammation contributes to AD pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
AutoDock and AutoDockTools for Protein-Ligand Docking: Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) as a Case Study
47/100 ✓ Peer-reviewed Risk genes beyond APOE Methods in molecular biology (Clifton, N.J.)
Key finding: Docking is used for optimizing known drugs and for identifying novel binders by predicting their binding mode and affinity. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-01
Impact of Cytokines and Chemokines on Alzheimer's Disease Neuropathological Hallmarks
44/100 ✓ Peer-reviewed Risk genes beyond APOE Current Alzheimer research
Key finding: Alzheimer's disease (AD) is the most common neurodegenerative disorder, neuropathologically characterized by aggregates of β-amyloid peptides, which deposit as senile plaques, and of TAU protein, which forms neurofibrillary tangles. +3 more findings
Full summary, score breakdown and related studies → Original source
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