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Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System
Chitu V, Gokhan Ş, Nandi S, Mehler MF, Stanley ER.. Trends in neurosciences, 2016-04-12
Topic: Brain proteins, microglia and lab models
The colony-stimulating factor-1 receptor (CSF-1R) kinase regulates tissue macrophage homeostasis, osteoclastogenesis, and Paneth cell development. However, recent studies in mice have revealed that CSF-1R signaling directly controls the development and maintenance of microglia, and cell autonomously regulates neuronal differentiation and survival. While the CSF-1R-cognate ligands, CSF-1 and interleukin-34 (IL-34) compete for binding to the CSF-1R, they are expressed in a largely non-overlapping manner by mature neurons.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Chitu, V., Ş, G., Nandi, S., Mehler, M. F., & Stanley, E. R. (2016). Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System. Trends in neurosciences. https://doi.org/10.1016/j.tins.2016.03.005
Vancouver
Chitu V, Ş G, Nandi S, Mehler MF, Stanley ER. Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System. Trends in neurosciences. 2016. doi:10.1016/j.tins.2016.03.005. PMID: 27083478.
BibTeX
@article{chitu2016-27083478,
author = {Chitu, V. and Ş, Gokhan and Nandi, S. and Mehler, M. F. and Stanley, E. R.},
title = {{Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System}},
journal = {Trends in neurosciences},
year = {2016},
doi = {10.1016/j.tins.2016.03.005},
pmid = {27083478},
url = {https://doi.org/10.1016/j.tins.2016.03.005}
}
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Key findings
- However, recent studies in mice have revealed that CSF-1R signaling directly controls the development and maintenance of microglia, and cell autonomously regulates neuronal differentiation and survival.
- While the CSF-1R-cognate ligands, CSF-1 and interleukin-34 (IL-34) compete for binding to the CSF-1R, they are expressed in a largely non-overlapping manner by mature neurons.
- The recent identification of a dominantly inherited, adult-onset, progressive dementia associated with inactivating mutations in the CSF-1R highlights the importance of CSF-1R signaling in the brain.
- We review the roles of the CSF-1R and its ligands in microglial and neural development and function, and their relevance to our understanding of neurodegenerative disease.
Why it matters
This review reports that in mice, CSF-1R signaling controls development and maintenance of microglia and regulates neuronal differentiation and survival, and notes an inherited adult-onset progressive dementia linked to inactivating mutations in this pathway. It reports no treatment or prevention result for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Trends in neurosciences) |
| Journal's citation record | 3 / 4 | Trends in Neurosciences: journal h-index 439 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 364 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 30.3 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 2 / 6 | Cited 2.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 3 / 4 | Cited 117 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author E. Richard Stanley: h-index 90 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Albert Einstein College of Medicine: institution h-index 973 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27083478) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
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