Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,851–17,875 of 27,380 studies, newest first · page 715 of 1096.
May 2014 25
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2014-05-16
APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis
74/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of neurology, neurosurgery, and psychiatry
Key finding: APOE ɛ4 was associated with atrophic hippocampal volume in MRI markers, increased cerebral amyloid deposition and cerebral hypometabolism. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-15
Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease
36/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: The presence of the ε4 allele has been associated with lower levels of apoE in both serum and brain tissues of normal and AD subjects. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-05-15
IFN-γ and TNF-α are involved during Alzheimer disease progression and correlate with nitric oxide production: a study in Algerian patients
44/100 ✓ Peer-reviewed Mild cognitive impairment Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Key finding: This disease is associated with an immune disorder, which appears with significant rise in the inflammatory cytokines and increased production of free radicals such as nitric oxide (NO). +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-14
Computerized and virtual reality cognitive training for individuals at high risk of cognitive decline: systematic review of the literature
71/100 ✓ Peer-reviewed Prevention trials The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: The positive effects on psychological outcomes (N = 6) were significant reductions on depressive symptoms (N = 3) and anxiety (N = 2) and improved perceived use of memory strategy (N = 1). +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-14
Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies: systematic review with meta-analysis and trial sequential analysis
66/100 ✓ Peer-reviewed Treatments Journal of neurology, neurosurgery, and psychiatry
Key finding: Recently, several large randomised controlled trials about the treatments of cognitive impairment or dementia due to Parkinson's disease (CIND-PD or PDD) and dementia with Lewy bodies (DLB) were completed. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-14
Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline
53/100 ✓ Peer-reviewed Disparities PloS one
Key finding: The multiple-adjusted odds ratio for the incidence of overall cognitive decline (dementia or MCI) was 0.32 (95% CI: 0.16-0.64) among individuals who consumed green tea every day and 0.47 (95% CI: 0.25-0.86) among those who consumed green tea 1-6 days per week compared with individuals who did not consume green tea at all. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-13
The drive-wise project: driving simulator training increases real driving performance in healthy older drivers
41/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience
Key finding: Driving simulator training offers the potential to enhance driving skills in older drivers. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-12
The contribution of vaccination to global health: past, present and future
36/100 ✓ Peer-reviewed Risk factors Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Key finding: Enhanced deployment of recently developed pneumococcal conjugate and rotavirus vaccines should, therefore, result in a further decline in childhood mortality.
Full summary, score breakdown and related studies → Original source
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2014-05-09
Food policies for physical and mental health
43/100 ✓ Peer-reviewed Risk factors BMC Psychiatry
Key finding: Recent evidence now indicates that unhealthy diets are also risk factors for mental disorders, particularly depression and dementia.
Full summary, score breakdown and related studies → Original source
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2014-05-09
Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking
45/100 ✓ Peer-reviewed Risk genes beyond APOE The American journal of pathology
Key finding: In particular, mitochondrial cholesterol enrichment has been shown to sensitize to Aβ-induced neurotoxicity. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-08
Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage
42/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neurotrauma
Key finding: Cerebral microbleeds, focal inflammation, and white matter damage are associated with many neurological and neurodegenerative disorders including CTE, AD, PD, vascular dementia, stroke, and TBI. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-07
Early intervention in Alzheimer's disease: a health economic study of the effects of diagnostic timing
46/100 ✓ Peer-reviewed Cognitive tests and assessment BMC neurology
Key finding: Intervention and treatment in Alzheimer's disease dementia (AD-dementia) can be cost effective but the majority of patients are not diagnosed in a timely manner. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-07
Initial cognitive decline is associated with cortical thinning in early Parkinson disease
52/100 ✓ Peer-reviewed Mild cognitive impairment Neurology
Key finding: These findings confirm that MCI is associated with widespread cortical atrophy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-06
Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders
36/100 ✓ Peer-reviewed Drug development ACS chemical neuroscience
Key finding: Lithium is a well-established therapeutic option for the acute and long-term management of bipolar disorder and major depression. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-06
Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment
44/100 ✓ Peer-reviewed Prevention and risk Journal of neuroinflammation
Key finding: Our results suggest that IF induces adaptive responses in the brain and periphery that can suppress inflammation and preserve cognitive function in an animal model of systemic bacterial infection. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-05
Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology
55/100 ✓ Peer-reviewed Lewy body dementia PloS one
Key finding: Extracellular miRNAs detectable in peripheral circulation can provide information about cellular changes associated with human health and disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-05-05
Multiple instance learning for classification of dementia in brain MRI
51/100 ✓ Peer-reviewed Digital health tools Medical image analysis
Key finding: However, not all the patches extracted from patients with dementia are equally affected by the disease and some of them may not be characteristic of morphology associated with the disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-05-05
Are there differences in the prevalence of palliative care-related problems in people living with advanced cancer and eight non-cancer conditions? A systematic review
65/100 ✓ Peer-reviewed Getting a diagnosis Journal of pain and symptom management
Key finding: There are commonalities in the prevalence of problems across cancer and non-cancer patients, highlighting the need for palliative care to be provided irrespective of diagnosis. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-05-04
Cognitive reserve and Alzheimer's disease
38/100 ✓ Peer-reviewed Risk factors Molecular neurobiology
Key finding: Cognitive reserve (CR) hypothesis is proposed to elucidate the disjunction between cognitive performance and the pathological level of AD, positing that some life span experiences will lend protection from AD pathological insults. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-03
Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease
55/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: However, interlaboratory variations in the results seen with currently available immunoassays are of concern.
Full summary, score breakdown and related studies → Original source
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2014-05-02
Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions
40/100 ✓ Peer-reviewed Drug development PloS one
Key finding: Overall, our study demonstrates a high risk of artefactual signal when performing Western blotting with routinely used anti-tau antibodies, and proposes several solutions to avoid non-specific results.
Full summary, score breakdown and related studies → Original source
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2014-05-02
The involvement of lipids in Alzheimer's disease
36/100 ✓ Peer-reviewed Biomarkers Journal of genetics and genomics = Yi chuan xue bao
Key finding: Evidence suggests that the ApoE protein, a major lipid transporter, plays a key role in the pathogenesis of AD, and its role in both normal and aberrant lipid metabolism warrants further extensive investigation.
Full summary, score breakdown and related studies → Original source
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2014-05-02
A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease
60/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia
Key finding: The research on SCD in early AD, however, is limited by the absence of common standards. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-02
Association of hypometabolism and amyloid levels in aging, normal subjects
52/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Hypometabolism in PiB-positive, cognitively normal subjects in a population-based cohort occurs in AD-signature cortical regions and to a lesser extent in other cortical regions. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-01
Concept Analysis: Alzheimer's Caregiver Stress
38/100 ✓ Peer-reviewed Caregiving Nursing forum
Key finding: A theoretical definition of caregiver stress is provided, and the defining attributes, related concepts, antecedents, and consequences of caregiver stress are proposed, and case studies are presented. +2 more findings
Full summary, score breakdown and related studies → Original source
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