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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 21,601–21,625 of 27,380 studies, newest first · page 865 of 1096.

February 2009 25

  1. 2009-02-27

    Mitochondrial ATP-synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer's disease pathology

    ✓ Peer-reviewed Disease mechanisms Brain pathology (Zurich, Switzerland)

    Key finding: Several proteins have been identified as targets of oxidative damage in AD dementia (usually stages V/VI of Braak) and in subjects with mild cognitive impairment associated with middle stages of AD pathology (stage IV of Braak). +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2009-02-26

    Widespread neocortical abnormalities in temporal lobe epilepsy with and without mesial sclerosis

    ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage

    Key finding: The pattern of thinning in TLE-no was different from the pattern in TLE-MTS. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2009-02-26

    Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

    ✓ Peer-reviewed Risk genes beyond APOE Science

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is familial in 10% of cases.

    Full summary, score breakdown and related studies → Original source

  4. 2009-02-26

    Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

    ✓ Peer-reviewed Risk genes beyond APOE Science

    Amyotrophic lateral sclerosis (ALS) is a fatal degenerative motor neuron disorder.

    Full summary, score breakdown and related studies → Original source

  5. 2009-02-26

    Differential placental gene expression in severe preeclampsia

    ✓ Peer-reviewed Brain tissue and pathology Placenta

    Key finding: Twenty-one women were randomly selected from 50 participants with uncomplicated pregnancies to match 21 patients with severe preeclampsia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2009-02-26

    Nature, prevalence and factors associated with depression among the elderly in a rural south Indian community

    ✓ Peer-reviewed Disparities International psychogeriatrics

    Key finding: Geriatric depression is prevalent in rural south India. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2009-02-26

    Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints

    ✓ Peer-reviewed Prevention and risk Stroke

    Key finding: Our data suggest that vascular abnormalities, independently of blood pressure levels, may play a role in the setting of subjective memory complaints as well as of WMH in elderly hypertensive patients. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2009-02-25

    Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology

    Key finding: Recently, we documented a high prevalence of Helicobacter pylori (Hp) infection in patients with AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2009-02-24

    {beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distribution

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: Emerging evidence suggests that soluble Abeta oligomers adversely affect synaptic function, which leads to cognitive failure associated with AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2009-02-23

    Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

    ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences of the United States of America

    Key finding: We demonstrate that metformin, at doses that lead to activation of the AMP-activated protein kinase (AMPK), significantly increases the generation of both intracellular and extracellular Abeta species. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2009-02-23

    Epigenetics, oxidative stress, and Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Free radical biology & medicine

    Key finding: The sporadic nature of 90% of AD cases, the differential susceptibility to and course of the illness, as well as the late age onset of the disease suggest that epigenetic and environmental components play a role in the etiology of late-onset AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2009-02-22

    Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy

    ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica

    Key finding: Arteries in the brain have two major functions (a) delivery of blood and (b) elimination of interstitial fluid and solutes, including amyloid-beta (Abeta), along perivascular pathways (lymphatic drainage). +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2009-02-22

    Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study

    ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society

    Key finding: Six thousand thirty community-dwelling persons aged 65 to 95. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2009-02-21

    Statins: mechanisms of neuroprotection

    ✓ Peer-reviewed Drug development Progress in neurobiology

    Key finding: However, the cholesterol synthesis pathway also has several by-products, the non-sterol isoprenoids that are also important in cellular functioning. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2009-02-19

    Recent developments in Alzheimer's disease therapeutics

    ✓ Peer-reviewed Costs and economics BMC medicine

    Key finding: Primary targets include beta-amyloid, whose presence and accumulation in the brain is thought to contribute to the development of Alzheimer's disease, and tau protein which, when hyperphosphorylated, results in the self-assembly of tangles of paired helical filaments also believed to be involved in the pathogenesis of Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  16. 2009-02-19

    Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

    ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Further, in transgenic cortex, microdeposits of oligomeric Abeta associate with a subset of excitatory synapses, which are significantly smaller than those not in contact with oligomeric Abeta. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2009-02-19

    Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies

    ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica

    Key finding: Although the amyloid-beta peptide is by far the commonest amyloid subunit implicated in sporadic and rarely in hereditary forms of CAA, a number of other proteins may also be involved in rare familial diseases in which CAA is also a characteristic morphological feature. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2009-02-18

    Can progressive and non-progressive behavioural variant frontotemporal dementia be distinguished at presentation?

    ✓ Peer-reviewed Digital health tools Journal of neurology, neurosurgery, and psychiatry

    Key finding: Progressive and non-progressive patients are difficult to differentiate on the basis of current clinical diagnostic criteria for FTD but a combination of general cognitive, executive dysfunction and impaired ADL measures appear to be the most promising discriminators. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2009-02-11

    S100beta protein expression: gender- and age-related daily changes

    ✓ Peer-reviewed Biomarkers Neurochemical research

    Key finding: These results confirm previous S100beta evaluations in human serum and cerebrospinal fluid reporting the protein's function as a biomarker for brain damage (Gazzolo et al. in Clin Chem 49:967-970, 2003; Clin Chim Acta 330:131-133, 2003; Pediatr Res 58:1170-1174, 2005), similar behavior was also observed for GFAP in relation to Alzheimer Disease (Fukuyama et al. in Eur Neurol 46:35-38, 2001). +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2009-02-09

    Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease

    ✓ Peer-reviewed Treatments Journal of neurology, neurosurgery, and psychiatry

    Key finding: This observational study revealed that the addition of the NMDA receptor antagonist memantine to the treatment of AD with ChEI significantly altered the treated history of AD by extending time to nursing home admission. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2009-02-09

    Epilepsy and cognitive impairments in Alzheimer disease

    ✓ Peer-reviewed How common it is Archives of neurology

    Key finding: Alzheimer disease (AD) is associated with cognitive decline and increased incidence of seizures. +2 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2009-02-08

    Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Nature medicine

    Key finding: Collectively, these findings indicate that BDNF exerts substantial protective effects on crucial neuronal circuitry involved in Alzheimer's disease, acting through amyloid-independent mechanisms.

    Full summary, score breakdown and related studies → Original source

  23. 2009-02-07

    Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders

    ✓ Peer-reviewed Getting a diagnosis European psychiatry : the journal of the Association of European Psychiatrists

    Key finding: The task force includes members of the Association Française de Psychiatrie Biologique, the European Psychiatric Association, the European Alzheimer's Disease Consortium and experts from Europe, Australia and North America. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2009-02-06

    Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment

    ✓ Peer-reviewed Mild cognitive impairment Radiology

    Key finding: Semiautomated, individually specific quantitative MR imaging methods can be used to identify a pattern of regional atrophy in MCI that is predictive of clinical decline. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2009-02-06

    A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging

    ✓ Peer-reviewed Down syndrome and Alzheimer's Biochimica et biophysica acta

    Key finding: More recently it has been shown that the proliferative and differentiative ability of stem cells decreases with age, suggesting that this may play a role in tissue aging. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →