Newest studies

Aerobic Training and Circulating Neurotrophins in Alzheimer's Disease Patients: A Controlled Trial

70/100 ✓ Peer-reviewed Prevention trials Experimental aging research

Key finding: After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified. +2 more findings

• Clinical Trials

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Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

41/100 ✓ Peer-reviewed Drug development Theranostics

Key finding: Aging is a natural process, which plays a critical role in the pathogenesis of a variety of diseases, i.e., aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease, cardiovascular diseases, cancers, obesity and other metabolic abnormalities. +3 more findings

• Treatments
• Risk Factors

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Feasibility and acceptability of a web-based advance care plan for dementia

41/100 ✓ Peer-reviewed End-of-life care Geriatric nursing (New York, N.Y.)

Key finding: While advance care planning (ACP) can help elicit preferences and is associated with improved end-of-life outcomes, persons living with dementia (PLWD) in nursing homes are rarely included in ACP. +2 more findings

• End-of-Life Care

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Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease

56/100 ✓ Peer-reviewed Inflammation and the immune system Molecular neurodegeneration

Key finding: The implication of gut microbiota in the control of brain functions in health and disease is a novel, currently emerging concept. +3 more findings

• Brain Biology

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APOE Effects on Late Life Cognitive Trajectories in Diverse Racial/Ethnic Groups

66/100 ✓ Peer-reviewed Disparities Journal of the International Neuropsychological Society : JINS

Key finding: ϵ4 prevalence in Black (46%) and White participants (46%) was almost double that of Latino participants (24%). ϵ4 was associated with poorer baseline episodic memory only in White participants (p = .001), but had a moderately strong association with episodic memory change across all racial/ethnic groups (Blacks= -.061 SD/year, Latinos = -.055,Whites= -.055). ϵ4 association with semantic memory change was strongest in White participants (-.071), intermediate in Latino participants (-.041), and weakest in Black participants (-.022). +3 more findings

• Health Equity
• Genetics

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Serum glial fibrillary acidic protein is a body fluid biomarker: A valuable prognostic for neurological disease - A systematic review

67/100 ✓ Peer-reviewed Biomarkers International immunopharmacology

Key finding: Our review shows an association between GFAP levels and the disease being studied, suggesting that elevated GFAP levels are a potentially valuable diagnostic biomarker in the evaluation of different neurological diseases.

• Biomarkers

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Psychodrama with persons with dementia on zoom: Proof of concept

34/100 ✓ Peer-reviewed Health systems and care delivery Dementia (London, England)

Key finding: Zooming from home, clients engaged in significant social interaction. +3 more findings

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Assessments of the Value of New Interventions Should Include Health Equity Impact

41/100 ✓ Peer-reviewed Disparities PharmacoEconomics

Key finding: An evidence-based quantitative assessment of the health equity impact can help decision makers develop coverage policies, programme designs, and quality initiatives focused on optimizing both total health and health equity given the treatment options available. +4 more findings

• Health Equity
• Treatments
• Policy

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Decreased imaging time of amyloid PET using [18F]florbetapir can maintain quantitative accuracy

41/100 ✓ Peer-reviewed Brain scans and imaging Radiological physics and technology

Key finding: Shortening the amount of time required to acquire amyloid positron emission tomography (PET) brain images while maintaining the accuracy of quantitative evaluation would help to overcome motion artifacts associated with Alzheimer's disease patients. +1 more finding

• Brain Scans

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Cohort Analysis of the Association of Delirium Severity With Cerebrospinal Fluid Amyloid-Tau-Neurodegeneration Pathologies

64/100 ✓ Peer-reviewed Biomarkers The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: Delirium is associated with cognitive decline and subsequent dementia, and rises in plasma total tau (tTau) and neurofilament light (NfL), providing links to Amyloid-Tau-Neurodegeneration (ATN) pathophysiology. +3 more findings

• Biomarkers

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Refining a Digital Therapeutic Platform for Home Care Agencies in Dementia Care to Elicit Stakeholder Feedback: Focus Group Study With Stakeholders

36/100 ✓ Peer-reviewed Health systems and care delivery JMIR aging

Key finding: Overall, 39 participants participated across the 6 stakeholder focus groups. +1 more finding

• Care Services
• Clinical Trials

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Impact of sleep duration on executive function and brain structure

58/100 ✓ Peer-reviewed Long-term cohort studies Communications biology

Key finding: Poor memory and increased risk of dementia is associated with the extremes of sleep quantity and disruption of other sleep characteristics. +3 more findings

• Lifestyle

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Early-Stage Alzheimer's Disease Prediction Using Machine Learning Models

53/100 ✓ Peer-reviewed Digital health tools Frontiers in public health

Key finding: The proposed work shows better results with the best validation average accuracy of 83% on the test data of AD. +1 more finding

• Digital Tools
• Early Stage

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Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application

63/100 ✓ Peer-reviewed Genetics Molecular neurodegeneration

Key finding: Extensive clinical and genomic studies have revealed biomarkers, risk factors, pathways, and targets of AD in the past decade. +1 more finding

• Genetics

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Metabolites of soil microorganisms modulate amyloid β production in Alzheimer's neurons

41/100 ✓ Peer-reviewed Biomarkers Scientific reports

Key finding: Screening results and following assessment of dose-dependency identified Verrucarin A, produced in Myrothecium spp., showed 80% decrease in Aβ production. +2 more findings

• Brain Biology

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Association of plasma biomarkers, p-tau181, glial fibrillary acidic protein, and neurofilament light, with intermediate and long-term clinical Alzheimer's disease risk: Results from a prospective cohort followed over 17 years

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: GFAP may be an early AD biomarker increasing before p-tau181 and NfL and the effect modifying role of cardiovascular health should be considered in biomarker risk stratification. +1 more finding

• Biomarkers

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Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's disease

46/100 ✓ Peer-reviewed Inflammation and the immune system Neurobiology of disease

Key finding: Iba1, and more specifically TMEM119 and P2RY12 are gaining ground as presumedly more specific microglia markers, but comprehensive characterization of the expression of these three markers individually as well as combined is currently missing. +3 more findings

• Brain Biology

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Palliative care for older people with dementia-we need a paradigm shift in our approach

41/100 ✓ Peer-reviewed End-of-life care Age and ageing

Key finding: A palliative care approach to dementia should look at symptoms across the four pillars of palliative care, but in reality, we tend to over-focus on physical and psychological symptoms, while spiritual and emotional needs can be overlooked, especially around the time of diagnosis, where such needs may be significant. +1 more finding

• End-of-Life Care

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Palliative Care and Dementia: What All Advanced Practice Nurses Should Know

41/100 ✓ Peer-reviewed End-of-life care Critical care nursing clinics of North America

Key finding: Dementia is a progressive, incurable condition that causes limitations in life and should be recognized as a life-limiting condition. +4 more findings

• End-of-Life Care

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The vascular risk factors and vascular neuropathology in subjects with autopsy-confirmed dementia with Lewy bodies

54/100 ✓ Peer-reviewed Vascular contributions International journal of geriatric psychiatry

Key finding: No significant differences of VRFs were identified between DLB and AD. +4 more findings

• Other Dementias
• Brain Biology
• Genetics

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Brain-gut-microbiota axis in Parkinson's disease: A historical review and future perspective

57/100 ✓ Peer-reviewed Disease mechanisms Brain research bulletin

Key finding: Clinical cohort studies suggest that certain intestinal microbes have protective or pathogenic effects on the progression of PD. +1 more finding

• Other Dementias

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Electroacupuncture ameliorates neuroinflammation in animal models

41/100 ✓ Peer-reviewed Inflammation and the immune system Acupuncture in medicine : journal of the British Medical Acupuncture Society

Key finding: A growing body of basic research has shown that EA can ameliorate neuroinflammation centrally (in animal models of ischemic stroke, Alzheimer's disease, traumatic brain injury, spinal cord injury, Parkinson's disease and vascular dementia) and peripherally (e.g. after a surgical insult or injection of lipopolysaccharide) and that its effects involve different molecular mechanisms, including activation of the α7 nicotinic acetylcholine receptor signaling pathway and P2 type purinergic receptors, inhibition of nuclear factor κB, and mitigation of damage secondary to oxidative stress and NOD-like receptor protein 3 inflammasome activation. +2 more findings

• Brain Biology

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Brain pathology and cognitive scores prior to onset of late-life depression

64/100 ✓ Peer-reviewed Risk factors International journal of geriatric psychiatry

Key finding: In the incident depression group, there was a mild decline in cognitive scores from baseline to the visit before depression onset compared with the never-depressed group. +4 more findings

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Effect of cognitive reserve on cognitive function in Parkinson's disease

70/100 ✓ Peer-reviewed Risk factors Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Key finding: The present study showed that higher educational levels were related to better general cognitive function, executive function, memory, and information processing speed in PD patients, whereas no significant association was showed between educational levels and visuospatial function, language in PD patients. +3 more findings

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The Laterality of Early Age-Related Hearing Loss and Brain β-Amyloid

57/100 ✓ Peer-reviewed Risk factors Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Key finding: Mean age ± standard deviation was 64.3 ± 3.5 years. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source