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Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease
Liao F, Yoon H, Kim J.. Current opinion in lipidology, 2017-02-01
Topic: Amyloid, tau and blood-test diagnosis
Purpose of review APOE4 genotype is the strongest genetic risk factor for Alzheimer's disease. Prevailing evidence suggests that amyloid β plays a critical role in Alzheimer's disease. The objective of this article is to review the recent findings about the metabolism of apolipoprotein E (ApoE) and amyloid β and other possible mechanisms by which ApoE contributes to the pathogenesis of Alzheimer's disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Liao, F., Yoon, H., & Kim, J. (2017). Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease. Current opinion in lipidology. https://doi.org/10.1097/mol.0000000000000383
Vancouver
Liao F, Yoon H, Kim J. Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease. Current opinion in lipidology. 2017. doi:10.1097/mol.0000000000000383. PMID: 27922847.
BibTeX
@article{liao2017-27922847,
author = {Liao, F. and Yoon, H. and Kim, J.},
title = {{Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease}},
journal = {Current opinion in lipidology},
year = {2017},
doi = {10.1097/mol.0000000000000383},
pmid = {27922847},
url = {https://doi.org/10.1097/mol.0000000000000383}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Prevailing evidence suggests that amyloid β plays a critical role in Alzheimer's disease.
- The objective of this article is to review the recent findings about the metabolism of apolipoprotein E (ApoE) and amyloid β and other possible mechanisms by which ApoE contributes to the pathogenesis of Alzheimer's disease.
- Recent findings ApoE isoforms have differential effects on amyloid β metabolism.
- Recent studies demonstrated that ApoE-interacting proteins, such as ATP-binding cassette A1 (ABCA1) and LDL receptor, may be promising therapeutic targets for Alzheimer's disease treatment.
Why it matters
This review states that APOE4 is the strongest genetic risk factor for Alzheimer's disease and that ApoE isoforms have differential effects on amyloid beta metabolism. It summarizes possible mechanisms by which ApoE contributes to disease but reports no treatment, cure or prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Current opinion in lipidology) |
| Journal's citation record | 2 / 4 | Current Opinion in Lipidology: journal h-index 155 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 193 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 17.5 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 4 / 6 | Cited 8.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 3 / 4 | Cited 61 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Jungsu Kim: h-index 49 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27922847) |
| Free to read | 2 / 2 | Free to read |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1097/mol.0000000000000383
- PubMed: 27922847
- Original source →
- Free full text: Current Opinion in Lipidology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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