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Epidemiology of Parkinson's disease
Tysnes OB, Storstein A.. Journal of neural transmission (Vienna, Austria : 1996), 2017-02-01
Topic: Risk, prevention and care in population studies
Parkinson's disease (PD) affects 1-2 per 1000 of the population at any time. PD prevalence is increasing with age and PD affects 1% of the population above 60 years. The main neuropathological finding is α-synuclein-containing Lewy bodies and loss of dopaminergic neurons in the substantia nigra, manifesting as reduced facilitation of voluntary movements. With progression of PD, Lewy body pathology spreads to neocortical and cortical regions. PD is regarded as a movement disorder with three cardinal signs: tremor, rigidity and bradykinesia. A recent revision of the diagnostic criteria excludes postural instability as a fourth hallmark and defines supportive criteria, absolute exclusion criteria and red flags. Non-motor symptoms in PD have gained increasing attention and both motor and non-motor signs are now included among the supportive criteria. The cause of PD is unknown in most cases. Genetic risk factors have been identified, including monogenetic causes that are rare in unselected populations. Some genetic factor can be identified in 5-10% of the patients. Several environmental factors are associated with increased risk of PD. Autopsy studies show that the clinical diagnosis of PD is not confirmed at autopsy in a significant proportion of patients. Revised diagnostic criteria are expected to improve the clinician´s accuracy in diagnosing PD. Increasing knowledge on genetic and environmental risk factors of PD will probably elucidate the cause of this disease within the near future.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Tysnes, O. B., & Storstein, A. (2017). Epidemiology of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). https://doi.org/10.1007/s00702-017-1686-y
Vancouver
Tysnes OB, Storstein A. Epidemiology of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2017. doi:10.1007/s00702-017-1686-y. PMID: 28150045.
BibTeX
@article{tysnes2017-28150045,
author = {Tysnes, O. B. and Storstein, A.},
title = {{Epidemiology of Parkinson's disease}},
journal = {Journal of neural transmission (Vienna, Austria : 1996)},
year = {2017},
doi = {10.1007/s00702-017-1686-y},
pmid = {28150045},
url = {https://doi.org/10.1007/s00702-017-1686-y}
}
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Key findings
- Several environmental factors are associated with increased risk of PD.
- Autopsy studies show that the clinical diagnosis of PD is not confirmed at autopsy in a significant proportion of patients.
Why it matters
This review describes how common Parkinson's disease is, its main brain findings and diagnostic criteria, and notes that the clinical diagnosis is not confirmed at autopsy in a significant proportion of patients. It is about Parkinson's disease epidemiology, not Alzheimer's disease treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neural transmission (Vienna, Austria : 1996)) |
| Journal's citation record | 2 / 4 | Journal of Neural Transmission: journal h-index 167 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 2,422 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 220.2 citations a year over 11 year(s) since 2017 |
| Impact for its field and year | 6 / 6 | Cited 92.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 4 / 4 | Cited 756 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Anette Margrethe Storstein: h-index 24 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Haukeland University Hospital: institution h-index 500 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28150045) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
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