Newest studies

Cerebrospinal fluid markers detect Alzheimer's disease in nonamnestic dementia

43/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Nineteen nonamnestic autopsied cases with relevant CSF values were included. +4 more findings

• Biomarkers
• Diagnosis

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Relationship between chewing ability and cognitive impairment in the rural elderly

52/100 ✓ Peer-reviewed Disparities Archives of gerontology and geriatrics

Key finding: Our findings suggest that poor chewing ability is associated with cognitive impairment or dementia in the elderly living in rural area. +3 more findings

• Health Equity
• Diagnosis

Full summary, score breakdown and related studies → Original source

Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial

76/100 ✓ Peer-reviewed Clinical safety PloS one

Key finding: Aerobic exercise in early AD is associated with benefits in functional ability. +3 more findings

• Clinical Trials
• Lifestyle

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Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

49/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: However, the manner in which disperse microscopic lesions reduce global cognitive function and increase the risk for Alzheimer's disease is unclear. +3 more findings

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Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report

48/100 ✓ Peer-reviewed Cognitive tests and assessment Photomedicine and laser surgery

Key finding: This study investigated whether patients with mild to moderately severe dementia or possible Alzheimer's disease (AD) with Mini-Mental State Exam (MMSE) Baseline scores of 10-24 would improve when treated with near-infrared photobiomodulation (PBM) therapy. +3 more findings

• Diagnosis

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The clinical and neurobehavioral course of Down syndrome and dementia with or without new-onset epilepsy

46/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Epilepsy & behavior : E&B

Key finding: New-onset epilepsy seems to occur early in the course of dementia in DS patients. +3 more findings

• Down Syndrome

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Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease

50/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Higher gLFC connectivity is a functional substrate of CR that helps to maintain episodic memory relatively well in the face of emerging FDG-PET hypometabolism in early-stage AD. +2 more findings

• Early Stage

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Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms

38/100 ✓ Peer-reviewed Disease mechanisms Trends in neurosciences

Key finding: Emerging findings suggest that the autophagy/lysosome pathway that removes damaged mitochondria (mitophagy) is also compromised in AD, resulting in the accumulation of dysfunctional mitochondria. +1 more finding

• Brain Biology

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Nursing home manager's knowledge, attitudes and beliefs about advance care planning for people with dementia in long-term care settings: a cross-sectional survey

53/100 ✓ Peer-reviewed End-of-life care Journal of clinical nursing

Key finding: Whilst nursing home managers recognise the potential benefits of advance care planning, barriers and challenges create a reluctance to facilitate. +2 more findings

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Use of Preventive Medication in Patients With Limited Life Expectancy: A Systematic Review

59/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

Key finding: Patients continue to receive medications that are not prescribed as symptomatic treatment despite having a LLE.

• Treatments
• End-of-Life Care

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Nursing home manager's knowledge, attitudes and beliefs about advance care planning for people with dementia in long‐term care settings: a cross‐sectional survey

43/100 ✓ Peer-reviewed Health systems and care delivery Journal of Clinical Nursing

Key finding: Whilst nursing home managers recognise the potential benefits of advance care planning, barriers and challenges create a reluctance to facilitate. +2 more findings

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis

52/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: As the population ages due to demographic trends and gains in life expectancy, the incidence and prevalence of dementia increases, and the need to understand the etiology and pathogenesis of dementia becomes ever more urgent. +4 more findings

• Risk Factors

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Cerebrospinal Fluid Biomarkers of Cognitive Decline in Parkinson's Disease

55/100 ✓ Peer-reviewed Tau biomarkers International review of neurobiology

Key finding: Longitudinal studies indicate that low levels of CSF Aβ42 are predictive of cognitive decline; however, results for tau and α-Syn were not consistent.

• Biomarkers
• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

41/100 ✓ Peer-reviewed Disease mechanisms Scientific reports

Key finding: To this end we sequenced bacterial 16S rRNA from fecal samples of Aβ precursor protein (APP) transgenic mouse model and found a remarkable shift in the gut microbiota as compared to non-transgenic wild-type mice. +2 more findings

• Brain Biology

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Narrative Organization Deficit in Lewy Body Disorders Is Related to Alzheimer Pathology

43/100 ✓ Peer-reviewed Tau biomarkers Frontiers in neuroscience

Key finding: Mildly demented LBD patients had a significant deficit judging narratives compared to non-demented patients, but this deficit was not correlated with MMSE. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Handgrip strength as a means of monitoring progression of cognitive decline - A scoping review

51/100 ✓ Peer-reviewed Mild cognitive impairment Ageing research reviews

Key finding: Studies that investigated changes in cognition relative to baseline grip strength and, those that investigated changes in grip strength relative to cognitive function were revealed.

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Gut microbiota: Implications in Parkinson's disease

41/100 ✓ Peer-reviewed Disease mechanisms Parkinsonism & related disorders

Key finding: A recent study has shown that Parkinson's disease patients suffer from GM dysbiosis, but whether it is a cause or an effect is yet to be understood.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Impact of Physical Activity on Cognitive Decline, Dementia, and Its Subtypes: Meta-Analysis of Prospective Studies

69/100 ✓ Peer-reviewed Prevention trials BioMed research international

Key finding: The overall sample from all studies is 117410 with the highest follow-up of 28 years. +1 more finding

• Lifestyle

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Nurses' experiences of pain management for people with advanced dementia approaching the end of life: a qualitative study

38/100 ✓ Peer-reviewed End-of-life care Journal of clinical nursing

Key finding: Achieving pain management in practice was highly challenging.

• End-of-Life Care

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Evaluation of a dietary screener: the Mediterranean Eating Pattern for Americans tool

52/100 ✓ Peer-reviewed Prevention trials Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

Key finding: The MEPA screener captures several components of the Mediterranean style pattern, although further testing of the MEPA screener is indicated. +1 more finding

• Lifestyle

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Transethnic genome-wide scan identifies novel Alzheimer's disease loci

53/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci. +2 more findings

• Genetics

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Prediction of Mild Cognitive Impairment Conversion Using a Combination of Independent Component Analysis and the Cox Model

44/100 ✓ Peer-reviewed Long-term cohort studies Frontiers in human neuroscience

Key finding: Thus, it is necessary to explore and predict the onset of AD in MCI stage. +3 more findings

• Early Stage

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Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?

45/100 ✓ Peer-reviewed TREM2 and immune genetics Neuroscience and biobehavioral reviews

Key finding: Chronic stress also primes microglia and induces inflammatory responses in the adult brain, thereby compromising synapse-supportive roles of microglia and deteriorating cognitive functions during aging. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Predicting behavioral variant frontotemporal dementia with pattern classification in multi-center structural MRI data

61/100 ✓ Peer-reviewed Digital health tools NeuroImage. Clinical

Key finding: Our study demonstrates that MRI, a widespread imaging technology, can individually identify bvFTD with high accuracy in multi-center imaging data, paving the road to personalized diagnostic approaches in the future. +1 more finding

• Brain Scans
• Other Dementias
• Digital Tools

Full summary, score breakdown and related studies → Original source

A systematic review of medication non-adherence in persons with dementia or cognitive impairment

67/100 ✓ Peer-reviewed Caregiving PloS one

Key finding: Fifteen studies met inclusion criteria. +2 more findings

• Treatments

Full summary, score breakdown and related studies → Original source