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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 15,476–15,500 of 27,380 studies, newest first · page 620 of 1096.

January 2017 25

  1. 2017-01-01

    Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies

    ✓ Peer-reviewed Drug development The journal of prevention of Alzheimer's disease

    Key finding: Preclinical studies have shown that antibodies against tau can prevent this transfer of misfolded tau between cells. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2017-01-01

    Amyloid-Related Imaging Abnormalities in an Aged Squirrel Monkey with Cerebral Amyloid Angiopathy

    ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

    Key finding: Histopathologic examination of the anomalous region revealed reactive astrocytosis and microgliosis, infiltration of systemic inflammatory/immune cells, damage to axons and myelin, and hemosiderin deposition. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2017-01-01

    Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage

    ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

    Key finding: The ARIA-H profile of verubecestat-treated mice was not significantly different than controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2017-01-01

    Central Review of Amyloid-Related Imaging Abnormalities in Two Phase III Clinical Trials of Bapineuzumab in Mild-To-Moderate Alzheimer's Disease Patients

    ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

    Key finding: ARIA was detected more often on MRI scans when every scan was reviewed by trained neuroradiologists and results adjudicated. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2017-01-01

    Clinical Development of Aducanumab, an Anti-Aβ Human Monoclonal Antibody Being Investigated for the Treatment of Early Alzheimer's Disease

    ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

    Key finding: However, none of the phase III clinical trials conducted to date that targeted amyloid β (Aβ) production, aggregation, or clearance demonstrated a statistically significant treatment effect in patients with AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2017-01-01

    The Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind

    ✓ Peer-reviewed Treatments Current neuropharmacology

    Key finding: Moreover, data have accumulated which clearly indicate that this small peptide plays a key role in the physiological processes of memory formation. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2017-01-01

    In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease

    ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD

    Key finding: The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-β. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2017-01-01

    Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study

    ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD

    Key finding: Future longitudinal studies examining the association of more severe depressive symptoms and cerebral tau accumulation are needed to substantiate this finding and to guide prevention and treatment in AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2017-01-01

    Biomarkers for the Early Detection and Progression of Alzheimer's Disease

    ✓ Peer-reviewed Brain scans and imaging Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    Key finding: However, the ultimate AD biomarker panel will likely involve the inclusion of novel CSF and blood biomarkers more precisely associated with confirmed pathophysiologic mechanisms to improve its reliability for detecting preclinical AD.

    Full summary, score breakdown and related studies → Original source

  10. 2017-01-01

    Genomic variants, genes, and pathways of Alzheimer's disease: An overview

    ✓ Peer-reviewed Genetics American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

    Key finding: With the gradual aging of the world's population, leading to increased prevalence of AD, and the substantial cost of care for those afflicted, identifying the genetic causes of disease represents a critical effort in identifying therapeutic targets. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2017-01-01

    Google Calendar Enhances Prospective Memory in Alzheimer's Disease: A Case Report

    ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD

    Key finding: We investigated whether an external memory aid (i.e., Google Calendar) would alleviate prospective memory compromise in a patient with mild Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  12. 2017-01-01

    Diagnostic Value of a Tablet-Based Drawing Task for Discrimination of Patients in the Early Course of Alzheimer's Disease from Healthy Individuals

    ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD

    Key finding: Time-in-air (i.e., transitioning from one stroke to the next without touching the surface) differed significantly between patients with aMCI, eDAT, and HCs demonstrating an excellent sensitivity and a moderate specificity to discriminate aMCI subjects from normal elderly and an excellent sensitivity and specificity to discriminate patients affected by mild Alzheimer's disease from healthy individuals.

    Full summary, score breakdown and related studies → Original source

  13. 2017-01-01

    Insulin Resistance and Future Cognitive Performance and Cognitive Decline in Elderly Patients with Cardiovascular Disease

    ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD

    Key finding: IR is related to subsequent poorer cognitive performance and greater cognitive decline among patients with cardiovascular disease with and without diabetes. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2017-01-01

    Computerized Cognitive Testing for Use in Clinical Trials: A Comparison of the NIH Toolbox and Cogstate C3 Batteries

    ✓ Peer-reviewed Cognitive tests and assessment The journal of prevention of Alzheimer's disease

    Key finding: Preliminary findings suggest that the NIH Toolbox has the advantage of showing the strongest overall clustering and alignment with standardized paper-and-pencil tasks. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2017-01-01

    Sleep Deprivation Induced Plasma Amyloid-β Transport Disturbance in Healthy Young Adults

    ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

    Key finding: Sleep deprivation can lead to an elevation of plasma Aβ40 and decrease of the Aβ42/Aβ40 ratio. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2017-01-01

    Cerebrospinal Fluid Aβ42/40 Corresponds Better than Aβ42 to Amyloid PET in Alzheimer's Disease

    ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

    Key finding: The CSF Aβ42/40 ratio is superior to Aβ42 alone as a marker of amyloid-positivity by PET. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2017-01-01

    The Cerebrospinal Fluid Aβ1-42/Aβ1-40 Ratio Improves Concordance with Amyloid-PET for Diagnosing Alzheimer's Disease in a Clinical Setting

    ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

    Key finding: We detected an increased concordance in the visual and quantitative (standardized uptake value ratio (SUVR) and total volume of distribution (VT)) [18F]AV45 PET measures when the CSF Aβ1-42/Aβ1-40 was applied compared to Aβ1-42 alone. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2017-01-01

    TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury

    ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Here, we show that the dendrite lengths and spine densities are reduced significantly in hippocampal CA1 pyramidal neurons, but increased in spinal neurokinin-1-positive neurons in mice after SNI, indicating that the excitatory synaptic connectivity is reduced in hippocampus but enhanced in spinal dorsal horn in this neuropathic pain model. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2017-01-01

    Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

    ✓ Peer-reviewed Hippocampus size on brain scans Science translational medicine

    Key finding: After reduction of human tau in this mouse model of tauopathy, fewer tau inclusions developed, and preexisting phosphorylated tau and Thioflavin S pathology were reversed. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2017-01-01

    Healthcare decision-making: past present and future, in light of a diagnosis of dementia

    ✓ Peer-reviewed End-of-life care International journal of palliative nursing

    Key finding: A person with dementia may lose the capacity to make decisions associated with advance care planning early in the course of the disease, requiring more involvement of family carers.

    Full summary, score breakdown and related studies → Original source

  21. 2017-01-01

    Effect of the Goals of Care Intervention for Advanced Dementia: A Randomized Clinical Trial

    ✓ Peer-reviewed End-of-life care JAMA internal medicine

    Key finding: Residents' mean age was 86.5 years, 39 (12.9%) were African American, and 246 (81.5%) were women.

    Full summary, score breakdown and related studies → Original source

  22. 2017-01-01

    Risk Factors Associated with Falls in Older Adults with Dementia: A Systematic Review

    ✓ Peer-reviewed Clinical safety Physiotherapy Canada. Physiotherapie Canada

    Key finding: A total of 17 studies met the inclusion criteria. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2017-01-01

    A 24-Week Multi-Modality Exercise Program Improves Executive Control in Older Adults with a Self-Reported Cognitive Complaint: Evidence from the Antisaccade Task

    ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD

    Key finding: Exercise programs involving aerobic and resistance training (i.e., multiple-modality) have shown promise in improving cognition and executive control in older adults at risk, or experiencing, cognitive decline.

    Full summary, score breakdown and related studies → Original source

  24. 2017-01-01

    Cognitive Rehabilitation in Alzheimer's Disease: A Controlled Intervention Trial

    ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD

    Key finding: Our study demonstrates the feasibility of a group-based Cognitive Rehabilitation program for patients with mild AD dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2017-01-01

    The relevance of nutrition for the concept of cognitive frailty

    ✓ Peer-reviewed Prevention trials Current opinion in clinical nutrition and metabolic care

    Key finding: Physical and cognitive frailty are interrelated and synergistic syndromes more frequently seen in old age, which represent intermediate stages between aging successfully and disability. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →