Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,101–15,125 of 27,380 studies, newest first · page 605 of 1096.
May 2017 20
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2017-05-02
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
51/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia (New York, N. Y.)
Key finding: Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-05 month only
Lewy Body Disorders
39/100 ✓ Peer-reviewed Brain tissue and pathology Neurologic clinics
Key finding: Dementia syndromes associated with Lewy bodies are subdivided into dementia with Lewy bodies (DLB), an underdiagnosed cause of dementia in the elderly, and Parkinson disease with dementia (PDD), cognitive impairment appearing in people diagnosed with Parkinson disease.
Full summary, score breakdown and related studies → Original source
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2017-05-01
Retinal Oximetry Discovers Novel Biomarkers in Retinal and Brain Diseases
39/100 ✓ Peer-reviewed Brain scans and imaging Investigative ophthalmology & visual science
Key finding: In diabetic retinopathy, venous oxygen saturation increases and arteriovenous difference decreases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Tau Positron Emission Tomography Imaging
39/100 ✓ Peer-reviewed Brain scans and imaging Cold Spring Harbor perspectives in biology
Key finding: Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia among the elderly population. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
38/100 ✓ Peer-reviewed Disease mechanisms Science translational medicine
Key finding: We found that 16-month-old APP/PS1; C3 KO mice performed better on a learning and memory task than did APP/PS1 mice, despite having more cerebral Aβ plaques. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease
52/100 ✓ Peer-reviewed Risk factors Nature medicine
Key finding: We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Insulin resistance and exendin-4 treatment for multiple system atrophy
41/100 ✓ Peer-reviewed Drug development Brain : a journal of neurology
Key finding: We here tested the hypothesis that multiple system atrophy is associated with brain insulin resistance and showed increased expression of the key downstream messenger insulin receptor substrate-1 phosphorylated at serine residue 312 in neurons and oligodendrocytes in the putamen of patients with multiple system atrophy. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model
45/100 ✓ Peer-reviewed Drug development Brain : a journal of neurology
Key finding: When administration of RN2N was combined with focused ultrasound in a scanning mode (scanning ultrasound), RN2N delivery into the brain and uptake by neurons were markedly increased, and efficacy was significantly enhanced.
Full summary, score breakdown and related studies → Original source
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2017-05-01
Diagnostic and Prognostic Biomarkers in Amyotrophic Lateral Sclerosis: Neurofilament Light Chain Levels in Definite Subtypes of Disease
67/100 ✓ Peer-reviewed Biomarkers JAMA neurology
Key finding: This study confirms the role of NFL as a biomarker in ALS. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity
38/100 ✓ Peer-reviewed Disease mechanisms Cold Spring Harbor perspectives in medicine
Key finding: However, soluble Aβ oligomers are most potent in creating synaptic dysfunction and loss. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Emergentology
23/100 ✓ Peer-reviewed Risk factors Emergency Medicine News
Key finding: If it takes a village to raise a child, it takes one to care for our ill as well. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Early-Onset Alzheimer Disease
49/100 ✓ Peer-reviewed Brain tissue and pathology Neurologic clinics
Key finding: EOAD comprises approximately 5% of AD and is associated with delays in diagnosis, aggressive course, and age-related psychosocial needs. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice
42/100 ✓ Peer-reviewed Drug development EMBO molecular medicine
Key finding: Imbalance between the production and clearance of amyloid β (Aβ) peptides is considered to be the primary mechanism of AD pathogenesis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Subjective Cognitive Decline in Preclinical Alzheimer's Disease
53/100 ✓ Peer-reviewed Mild cognitive impairment Annual review of clinical psychology
Key finding: Yet methodological challenges associated with establishing common assessment and classification procedures hamper the construct. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial (PREADViSE)
74/100 ✓ Peer-reviewed Disparities JAMA neurology
Key finding: In both phases, men were encouraged to visit their physician if the screen results indicated possible cognitive impairment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study
56/100 ✓ Peer-reviewed Prevention and risk Stroke
Key finding: Artificially sweetened soft drink consumption was associated with a higher risk of stroke and dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Hearing Impairment and Incident Dementia and Cognitive Decline in Older Adults: The Health ABC Study
59/100 ✓ Peer-reviewed Prevention and risk The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: HI is associated with increased risk of developing dementia in older adults. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Management of Depression in Older Adults: A Review
57/100 ✓ Peer-reviewed Prevention and risk JAMA
Key finding: Major depression in older adults is common and can be effectively treated with antidepressants and electroconvulsive therapy. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-05-01
Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice
43/100 ✓ Peer-reviewed Genetics eNeuro
Key finding: We observed that metabolic outcomes of DIO were similar in E3FAD and E4FAD mice. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-05-01
Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease
75/100 ✓ Peer-reviewed Biomarkers JAMA neurology
Key finding: Among 193 cognitively healthy controls, 197 patients with mild cognitive impairment, and 180 patients with AD with dementia, plasma NFL correlated with CSF NFL (Spearman ρ = 0.59, P Conclusions and relevance Plasma NFL is associated with AD diagnosis and with cognitive, biochemical, and imaging hallmarks of the disease. +2 more findings
Full summary, score breakdown and related studies → Original source
April 2017 5
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2017-04-29
Synaptic Dysfunction in Alzheimer's Disease: Aβ, Tau, and Epigenetic Alterations
39/100 ✓ Peer-reviewed Disease mechanisms Molecular neurobiology
Key finding: Evidence suggests that Aβ and Tau oligomers contribute to synaptic loss in AD.
Full summary, score breakdown and related studies → Original source
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2017-04-29
Activation of Glucagon-Like Peptide-1 Receptor Promotes Neuroprotection in Experimental Autoimmune Encephalomyelitis by Reducing Neuroinflammatory Responses
38/100 ✓ Peer-reviewed Drug development Molecular neurobiology
Key finding: Here, we studied whether multiple sclerosis (MS) could be a complement to the CNS disorders that are associated with the GLP-1/GLP-1R signaling axis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-04-28
Palliative care for people with dementia in the terminal phase: a mixed-methods qualitative study to inform service development
41/100 ✓ Peer-reviewed End-of-life care BMC palliative care
Key finding: A mobile team that specializes in palliative care in dementia and supports professional and family caregivers is a promising model. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-04-27
Implementing monitoring technologies in care homes for people with dementia: A qualitative exploration using Normalization Process Theory
48/100 ✓ Peer-reviewed Digital health tools International journal of nursing studies
Key finding: Ageing societies and a rising prevalence of dementia are associated with increasing demand for care home places. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-04-26
Age-related white matter integrity differences in oldest-old without dementia
39/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging
Key finding: Aging is known to have deleterious effects on cerebral white matter, yet little is known about these white matter alterations in advanced age. +2 more findings
Full summary, score breakdown and related studies → Original source
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