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56/100

✓ Peer-reviewed alzhub usefulness score 56 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

Aims Cardiometabolic diseases (hypertension, coronary artery disease [CAD] and diabetes are known to associate with poorer cognitive ability but there are limited data on whether having more than one of these conditions is associated with additive effects. We aimed to quantify the magnitude of their associations with non-demented cognitive abilities and determine the extent to which these associations were additive. Methods and results We examined cognitive test scores in domains of reasoning, information processing speed and memory, included as part of the baseline UK Biobank cohort assessment (N = 474 129 with relevant data), adjusting for a range of potentially confounding variables.

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APA 7th

Lyall, D. M., Celis-Morales, C. A., Anderson, J., Gill, J. M., Mackay, D. F., McIntosh, A. M., et al. (2017). Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants. European heart journal. https://doi.org/10.1093/eurheartj/ehw528

Vancouver

Lyall DM, Celis-Morales CA, Anderson J, Gill JM, Mackay DF, McIntosh AM, et al. Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants. European heart journal. 2017. doi:10.1093/eurheartj/ehw528. PMID: 28363219.

BibTeX

@article{lyall2017-28363219,
  author  = {Lyall, D. M. and Celis-Morales, C. A. and Anderson, J. and Gill, J. M. and Mackay, D. F. and McIntosh, A. M. and Smith, D. J. and Deary, I. J. and others},
  title   = {{Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants}},
  journal = {European heart journal},
  year    = {2017},
  doi     = {10.1093/eurheartj/ehw528},
  pmid    = {28363219},
  url     = {https://doi.org/10.1093/eurheartj/ehw528}
}

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Key findings

We aimed to quantify the magnitude of their associations with non-demented cognitive abilities and determine the extent to which these associations were additive.
Methods and results We examined cognitive test scores in domains of reasoning, information processing speed and memory, included as part of the baseline UK Biobank cohort assessment (N = 474 129 with relevant data), adjusting for a range of potentially confounding variables.
The presence of hypertension, CAD and diabetes generally associated with poorer cognitive scores on all tests, compared with a control group that reported none of these diseases.
There was evidence of an additive deleterious dose effect of an increasing number of cardiometabolic diseases, for reasoning scores (unstandardized additive dose beta per disease = -0.052 score points out of 13, 95% CI [confidence intervals] -0.063 to - 0.041, P < 0.001), log reaction time scores (exponentiated beta = 1.005, i.e. 0.5% slower, 95% CI 1.004-1.005, P < 0.001) and log memory errors (exponentiated beta = 1.005 i.e. 0.5% more errors; 95% CI 1.003-1.008).

Why it matters

This study examined whether having hypertension, coronary artery disease or diabetes, alone or together, is associated with poorer cognitive abilities in people without dementia. It is observational and does not test whether treating these conditions prevents dementia.

Study details

Participants474
Evidence strengthModerate

How this study scored 56/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (European heart journal)
Journal's citation record	3 / 4	European Heart Journal: journal h-index 456 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	2 / 4	474 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 100 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	9.1 citations a year over 11 year(s) since 2017
Impact for its field and year	3 / 6	Cited 3.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 7 other studies in this library
Still being cited	2 / 4	Cited 41 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Jill P. Pell: h-index 101 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Glasgow: institution h-index 1,600 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28363219)
Free to read	2 / 2	Free to read
Total	56 / 100	—

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