Newest studies

Insomnia and somnolence in idiopathic RBD: a prospective cohort study

57/100 ✓ Peer-reviewed Risk factors NPJ Parkinson's disease

Key finding: Finally, on polysomnogram, those with increased tonic rapid eye movement had higher risk of developing defined neurodegenerative disease (HR = 1.88, p = 0.039). +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

The gut microbiome in human neurological disease: A review

41/100 ✓ Peer-reviewed Disease mechanisms Annals of neurology

Key finding: These microorganisms collectively form the human microbiota, with most colonizing the gut. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Typical and atypical pathology in primary progressive aphasia variants

62/100 ✓ Peer-reviewed Lewy body dementia Annals of neurology

Key finding: Each PPA clinical variant is associated with a typical and most frequent cognitive, neuroimaging, and neuropathological profile. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease

43/100 ✓ Peer-reviewed Risk genes beyond APOE Neuroscience letters

Key finding: It has been shown that the activity of nicotinamide adenine dinucleotide (NAD+) is related with the decline of Aβ toxicity in AD. +3 more findings

Full summary, score breakdown and related studies → Original source

Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals

38/100 ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Alzheimer's disease (AD) is characterized by two hallmark molecular pathologies: amyloid aβ 1-42 and Tau neurofibrillary tangles. +2 more findings

• Brain Scans
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. The SENATOR-OnTop series

62/100 ✓ Peer-reviewed Clinical safety BMJ open

Key finding: A large number of non-pharmacological interventions for BPSD were identified. +1 more finding

Full summary, score breakdown and related studies → Original source

A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis

45/100 ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica communications

Key finding: Continued focus on mutation-specific upstream mechanisms has yet to predict disease progression in the clinic. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Hearing loss as a risk factor for dementia: A systematic review

62/100 ✓ Peer-reviewed Prevention and risk Laryngoscope investigative otolaryngology

Key finding: Level of evidence Level V, systematic review. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Astrocytes and synaptic plasticity in health and disease

39/100 ✓ Peer-reviewed Disease mechanisms Experimental brain research

Key finding: Regulation of synaptic plasticity is critical for healthy cognition and learning and this is provided in part by metaplasticity, which can act to maintain synaptic transmission within a dynamic range and potentially prevent excitotoxicity. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Apolipoprotein E: the resilience gene

39/100 ✓ Peer-reviewed Genetics Experimental brain research

Key finding: We found a significantly higher resilience in participants with apoE genotype containing the E2 allele (E2/2, E2/3) as compared to participants with the E4 allele (E4/4, E4/3). +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings

63/100 ✓ Peer-reviewed Inflammation and the immune system Ageing research reviews

Key finding: Tau PET imaging has also revealed characteristic spatial patterns among various non-AD tauopathies, supporting its potential role for differential diagnosis.

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

2017 Alzheimer's disease facts and figures

36/100 ✓ Peer-reviewed End-of-life care Alzheimer s & Dementia

Key finding: This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care, and the overall impact on caregivers and society.

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Challenges and opportunities in understanding dementia and delirium in the acute hospital

41/100 ✓ Peer-reviewed Clinical safety PLoS medicine

Key finding: In an Essay, Andrew Jackson and colleagues discuss challenges in the diagnosis and management of older people with dementia and delirium in acute hospitals.

• Care Services

Full summary, score breakdown and related studies → Original source

Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan

43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

Key finding: The current study describes in vitro 3 H-PiB binding in the frontal cortex of autopsy cases with DS compared to non-DS controls. +2 more findings

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy

41/100 ✓ Peer-reviewed Drug development Scientific reports

Key finding: Mass spectrometry studies indicate that tau acetylation sites cluster within the microtubule (MT)-binding region (MTBR), suggesting acetylation could regulate both normal and pathological tau functions.

Full summary, score breakdown and related studies → Original source

Tuning Up the Old Brain with New Tricks: Attention Training via Neurofeedback

41/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience

Key finding: More published studies have demonstrated the efficacy of NF, particularly for treating attention deficit hyperactivity disorder (ADHD) in children. +1 more finding

Full summary, score breakdown and related studies → Original source

Frequency and Risk Factors for Live Discharge from Hospice

61/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: Roughly one in five hospice patients were discharged alive (21%; n = 1911). +1 more finding

• End-of-Life Care
• Risk Factors

Full summary, score breakdown and related studies → Original source

Benefit-finding and effect on caregiver depression: A double-blind randomized controlled trial

64/100 ✓ Peer-reviewed Treatments Journal of consulting and clinical psychology

Key finding: Finding positive gains is an effective intervention to reduce depressive symptoms among Alzheimer caregivers. +1 more finding

• Clinical Trials
• Caregiving

Full summary, score breakdown and related studies → Original source

Interactive wearable systems for upper body rehabilitation: a systematic review

67/100 ✓ Peer-reviewed Treatments Journal of neuroengineering and rehabilitation

Key finding: This review has shown that wearable systems are used mostly for the monitoring and provision of feedback on posture and upper extremity movements in stroke rehabilitation. +3 more findings

• Digital Tools
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Selective deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease (APP/PS1) mice by inhibiting TGF-β/Smad2/STAT3 signaling

40/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging

Key finding: Whole body deletion of apoE significantly ameliorated the spatial learning and memory impairment, reduced amyloid β-protein production and inhibited astrogliosis in APP/apoE KO mice, as well as specific deletion apoE in astrocytes in APP/GFAP-apoE KO mice. +2 more findings

• Brain Biology
• Genetics
• Biomarkers

Full summary, score breakdown and related studies → Original source

Visual dysfunction and its correlation with retinal changes in patients with Alzheimer's disease

45/100 ✓ Peer-reviewed Risk factors Eye (London, England)

Key finding: Structural measurements of the retinal nerve fiber layer (RNFL) and macular thickness were obtained using spectral domain-optical coherence tomography (SD-OCT).ResultsCSV at three of the four spatial frequencies was significantly worse in AD patients than in controls. +4 more findings

Full summary, score breakdown and related studies → Original source

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases

38/100 ✓ Peer-reviewed Brain scans and imaging Prostaglandins, leukotrienes, and essential fatty acids

Key finding: Evidence mostly from non-human studies suggests that DHA intake above normal nutritional requirements might modify the risk/course of a number of diseases of the brain. +1 more finding

Full summary, score breakdown and related studies → Original source

Dementia and delirium, the outcomes in elderly hip fracture patients

69/100 ✓ Peer-reviewed Clinical safety Clinical interventions in aging

Key finding: Elderly patients with a hip fracture are vulnerable for delirium, especially when the patient has dementia. +3 more findings

Full summary, score breakdown and related studies → Original source

Predicting conversion from MCI to AD using resting-state fMRI, graph theoretical approach and SVM

41/100 ✓ Peer-reviewed Digital health tools Journal of neuroscience methods

Key finding: Using subset of optimal features in SVM, we classified MCI-C from MCI-NC with an accuracy, sensitivity, specificity, and the area under the receiver operating characteristic (ROC) curve of 91.4%, 83.24%, 90.1%, and 0.95, respectively. +2 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Stem cell reports

Key finding: Further studies demonstrated that this effect is not due to an interaction with the core γ-secretase responsible for Aβ production.

• Down Syndrome
• Diagnosis

Full summary, score breakdown and related studies → Original source