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Regulation of Cognitive Processing by Hippocampal Cholinergic Tone
Mohammed A Al-Onaizi, Gustavo M Parfitt, Benjamin Kolisnyk, Clayton S H Law, Monica S Guzman, Daniela Martí Barros, L Stan Leung, Marco A M Prado et al.. Cerebral cortex (New York, N.Y. : 1991), 2017-02-01
Topic: Disease mechanisms in lab and animal studies
Cholinergic dysfunction has been associated with cognitive abnormalities in a variety of neurodegenerative and neuropsychiatric diseases. Here we tested how information processing is regulated by cholinergic tone in genetically modified mice targeting the vesicular acetylcholine transporter (VAChT), a protein required for acetylcholine release. We measured long-term potentiation of Schaffer collateral-CA1 synapses in vivo and assessed information processing by using a mouse touchscreen version of paired associates learning task (PAL). Acquisition of information in the mouse PAL task correlated to levels of hippocampal VAChT, suggesting a critical role for cholinergic tone. Accordingly, synaptic plasticity in the hippocampus in vivo was disturbed, but not completely abolished, by decreased hippocampal cholinergic signaling. Disrupted forebrain cholinergic signaling also affected working memory, a result reproduced by selectively decreasing VAChT in the hippocampus. In contrast, spatial memory was relatively preserved, whereas reversal spatial memory was sensitive to decreased hippocampal cholinergic signaling. This work provides a refined roadmap of how synaptically secreted acetylcholine influences distinct behaviors and suggests that distinct forms of cognitive processing may be regulated in different ways by cholinergic activity.
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APA 7th
Al-Onaizi, M. A., Parfitt, G. M., Kolisnyk, B., Law, C. S. H., Guzman, M. S., Barros, D. M., et al. (2017). Regulation of Cognitive Processing by Hippocampal Cholinergic Tone. Cerebral cortex (New York, N.Y. : 1991). https://doi.org/10.1093/cercor/bhv349
Vancouver
Al-Onaizi MA, Parfitt GM, Kolisnyk B, Law CSH, Guzman MS, Barros DM, et al. Regulation of Cognitive Processing by Hippocampal Cholinergic Tone. Cerebral cortex (New York, N.Y. : 1991). 2017. doi:10.1093/cercor/bhv349. PMID: 26803167.
BibTeX
@article{alonaizi2017-26803167,
author = {Al-Onaizi, Mohammed A and Parfitt, Gustavo M and Kolisnyk, Benjamin and Law, Clayton S H and Guzman, Monica S and Barros, Daniela Martí and Leung, L Stan and Prado, Marco A M and others},
title = {{Regulation of Cognitive Processing by Hippocampal Cholinergic Tone}},
journal = {Cerebral cortex (New York, N.Y. : 1991)},
year = {2017},
doi = {10.1093/cercor/bhv349},
pmid = {26803167},
url = {https://doi.org/10.1093/cercor/bhv349}
}
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Key findings
- Cholinergic dysfunction has been associated with cognitive abnormalities in a variety of neurodegenerative and neuropsychiatric diseases.
- Disrupted forebrain cholinergic signaling also affected working memory, a result reproduced by selectively decreasing VAChT in the hippocampus.
- This work provides a refined roadmap of how synaptically secreted acetylcholine influences distinct behaviors and suggests that distinct forms of cognitive processing may be regulated in different ways by cholinergic activity.
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cerebral cortex (New York, N.Y. : 1991)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26803167) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
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