Newest studies

Informal Caregiver Outcomes in Home-Based Dyadic Dementia Interventions: A Scoping Review

59/100 ✓ Peer-reviewed Caregiving Journal of evidence-based social work (2019)

Key finding: An initial database search yielded 3,977 studies of which 22 were included in this review. +4 more findings

• Caregiving

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Syringin attenuates Alzheimer's disease-associated neuroinflammation by inhibiting NLRP3 inflammasome activation

43/100 ✓ Peer-reviewed Inflammation and the immune system Phytomedicine : international journal of phytotherapy and phytopharmacology

Key finding: In the MWM, syringin reduced escape latency. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Cognitive dispersion is associated with white matter hyperintensities in amyloid positive older adults

43/100 ✓ Peer-reviewed Vascular contributions The Clinical Neuropsychologist

Key finding: Amyloid status moderated associations between IIV-dispersion and WMH, such that higher IIV-dispersion was associated with greater WMH in Aß+ individuals whether WMH was examined as a continuous (B = 0.30, ß = 0.13, p = .006) or a dichotomous variable based on quartiles (odds ratio [OR] = 2.41, p < .001). +3 more findings

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EEG Microstate Differences Between Alzheimer’s Disease, Frontotemporal Dementia, and Healthy Controls Using 4 and 7 Clustering Classes with a Ratio Approach

36/100 ✓ Peer-reviewed Cognitive tests and assessment Medicina

Key finding: The four- and seven-class clustering solutions achieved high variance overlap with published microstate templates. +3 more findings

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Cheese Consumption and Incidence of Dementia in Community-Dwelling Older Japanese Adults: The JAGES 2019–2022 Cohort Study

50/100 ✓ Peer-reviewed How common it is Nutrients

Key finding: After PSM, 7914 participants were analyzed (3957 consumers; 3957 non-consumers). +4 more findings

• Risk Factors

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Development of Biotin and Horseradish Peroxidase Labelling against Monoclonal Antibody Amyloid-β42 and Its Application on Enzyme-Linked Immunosorbent Assay

25/100 ✓ Peer-reviewed Treatments Jurnal Penelitian Pendidikan IPA

Key finding: The molecular mass of the conjugated antibodies was characterized with SDS-PAGE, result shows the pre-conjugated antibody has 150 kDa bands, conjugated antibody with labels is heavier than the pre-conjugated due to the addition of each label. +1 more finding

• Treatments

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ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer's Disease Pathogenesis

43/100 ✓ Peer-reviewed Genetics Biochemistry

Key finding: Compared to ApoE3 or the Alzheimer's disease-protective ApoE2 variant, the recovered yield of the LNP form of the disease-predisposing ApoE4 variant is higher.

• Genetics

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Computerized cognitive training enhances cognitive function in Alzheimer's disease by downregulating Ruminococcus-TMAO pathway

79/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of translational medicine

Key finding: Seventy-four participants completed the study. +4 more findings

• Clinical Trials

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Association between cerebrospinal fluid CXCL10 and neurocognitive disorders in people living with HIV: a meta-analysis

44/100 ✓ Peer-reviewed Inflammation and the immune system AIDS research and therapy

Key finding: Eleven studies involving 1,536 PLWH were included. +3 more findings

• Biomarkers

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Continuity of primary care and end-of-life care costs in dementia: a retrospective cohort study

43/100 ✓ Peer-reviewed End-of-life care British Journal of General Practice

Key finding: = 18 556) lived in care homes before death. +3 more findings

• Care Services
• End-of-Life Care
• Policy

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Pain, agitation, and delirium practices in Chinese intensive care units: A national multicenter survey study

48/100 ✓ Peer-reviewed Clinical safety Chinese Medical Journal

Key finding: To the Editor: The standardized management of pain–agitation–delirium (PAD) represents a fundamental component of clinical practice in intensive care units (ICUs).[1] Evidence-based analgesia and sedation strategies not only alleviate patients’ physiological discomfort and psychological distress, but also significantly reduce mechanical ventilation duration, improve long-term prognosis, and optimize healthcare resource allocation.[1,2] Equally crucial is delirium management, as evidenced by studies demonstrating that delirium duration independently predicts mortality risk, hospital stay length, healthcare expenditures, and acquired dementia incidence.[3] Although existing studies have explored PAD management practices, most rely on clinicians’ subjective recall that may distort objective clinical realities and fail to reflect distinctive characteristics.[4] Therefore, this nationwide multicenter cross-sectional study, initiated by the Critical Care Analgesia and Sedation Quality Control Subspecialty Group under the China National Center for Medical Quality Control in Critical Care Medicine, aims to investigate the current status of PAD management in China. +4 more findings

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The role of neutrophils, red blood cells, and platelets in the pathology of Alzheimer’s disease

35/100 ✓ Peer-reviewed Disease mechanisms Annals of Medicine

Key finding: Emerging evidence transcends the traditional central nervous system (CNS)-centric perspective, revealing that neutrophils, red blood cells (RBCs), and platelets may play critical roles in AD pathogenesis by modulating systemic inflammatory responses, disrupting blood-brain barrier integrity, and participating in the CNS-peripheral interactions. +1 more finding

• Brain Biology

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Delta-opioid receptor ameliorates microglia-induced synapse loss by regulating C1q in Alzheimer disease pathology

36/100 ✓ Peer-reviewed Inflammation and the immune system Brain Behavior and Immunity

Key finding: Consistent with these findings, overexpressing microglial DOR effectively inhibited its shift towards a phagocytotic phenotype and protected co-cultured neurons from lipopolysaccharide (LPS) -induced injury. +1 more finding

• Brain Biology

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Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology

49/100 ✓ Peer-reviewed Brain tissue and pathology Nature Communications

Key finding: Both ligands bind with high affinity to aggregated, but not soluble, TDP-43 in patient brain samples from diverse TDP-43 proteinopathies, including frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), ALS, and LATE, and in cell models. +4 more findings

• Brain Scans
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Recommended best practices for construct-centered adaptation of the Harmonized Cognitive Assessment Protocol

46/100 ✓ Peer-reviewed Getting a diagnosis The Journals of Gerontology Series B

Key finding: Recommendations for HCAP adaptation include phases of preparation (assembling local expert teams; resource planning), implementation (construct-centered adaptation guided by local experts), pre-testing (iterative, mixed-methods approach), and field preparation (creating documentation; interviewer training; planning for ongoing quality assurance). +3 more findings

• Diagnosis

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Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health

60/100 ✓ Peer-reviewed Prevention and risk Communications Medicine

Key finding: The highest-risk group (Q4) shows a 2.8-fold increased risk of Alzheimer’s disease, a 6.4-fold risk of multiple sclerosis, and a 2.4-fold higher mortality risk. +4 more findings

• Lifestyle
• Risk Factors

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LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies

46/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica

Key finding: Parkinson's disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with endolysosomal dysfunction across cell types, and carriers of LRRK2 mutations variably present with phosphorylated tau and α-synuclein deposits in post-mortem analysis. +2 more findings

• Brain Biology

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Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv : the preprint server for health sciences

Key finding: We identified 91 genetic loci associated with ADRD risk, including 16 which are novel, and 56 which are specifically detected in clinically diagnosed AD cases. +2 more findings

• Genetics
• Brain Biology

Scored 48 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Dementia risk literacy in older Australians: beyond knowledge

43/100 ✓ Peer-reviewed Prevention trials Public Health Research & Practice

Key finding: Participants numbered 3334 and had a median age of 62 years. +4 more findings

• Risk Factors
• Prevention
• Lifestyle

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Computational Insights into the Destabilization of Baicalein on the Tau Protofibrils Associated with Alzheimer’ s Disease and Chronic Traumatic Encephalopathy

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of Physical Chemistry B

Key finding: It is revealed that the three-dimensional configurations of the protofibrils in AD and CTE-specific tau filaments are rather similar. +1 more finding

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Auditory Hallucinations as the First Symptom of Alzheimer´s Disease – A Case Report

30/100 ✓ Peer-reviewed Brain scans and imaging Current Alzheimer Research

Key finding: Auditory hallucinations in older age could be the first symptom of AD and even occur before cognitive decline.

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Interview – Interview zum Thema: Neue Alzheimer-Therapien: Warum Radiolog:innen ARIA kennen müssen

28/100 ✓ Peer-reviewed Treatments RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

Key finding: Elke Hattingen, Direktorin der Klinik für Neuroradiologie am Universitätsklinikum Frankfurt am Main, einen Überblick über die typischen MRT-Befunde, über die bildmorphologischen Verläufe und die Risikofaktoren von ARIA. +4 more findings

• Treatments
• Side Effects

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Neue Alzheimer-Therapien: Vortrag zu ARIA für eine sichere MRT-Diagnostik

28/100 ✓ Peer-reviewed Treatments RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

Key finding: Mit der Einführung neuer Alzheimer-Therapien wie den Anti-Amyloid-Antikörpern Lecanemab und Donanemab rückt ein bislang wenig bekanntes, aber hochaktuelles Phänomen in den Fokus: ARIA – Amyloid-related Imaging Abnormalities. +3 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Privación del Sueño y Melatonina Factores que Influyen en la Enfermedad de Alzheimer: Revisión Sistemática

26/100 ✓ Peer-reviewed Genetics Ciencia Latina Revista Científica Multidisciplinar

Key finding: De 1.559 registros, se incluyeron 24 estudios. +4 more findings

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Racial/ethnic differences in neuropsychological test performance in frontotemporal degeneration

54/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Minoritized individuals had lower scores and/or greater likelihood of impairment on measures of lexical retrieval, processing speed, cognitive flexibility, and working memory but not global cognition, verbal recall, attention, and category fluency. +4 more findings

• Health Equity
• Other Dementias

Full summary, score breakdown and related studies → Original source