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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 15,976–16,000 of 27,380 studies, newest first · page 640 of 1096.

June 2016 25

  1. 2016-06-27

    The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

    ✓ Peer-reviewed Lewy body dementia Nature medicine

    Key finding: Here we have found that TDP-43 accumulates in the mitochondria of neurons in subjects with ALS or frontotemporal dementia (FTD). +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2016-06-27

    Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

    ✓ Peer-reviewed Risk factors Journal of neuroscience research

    Key finding: There is significant evidence that pathways involving inflammation and oxidative-nitrosative stress (ONS) play a key pathophysiological role in promoting cognitive dysfunction.

    Full summary, score breakdown and related studies → Original source

  3. 2016-06-27

    Feasibility of an Immersive Virtual Reality Intervention for Hospitalized Patients: An Observational Cohort Study

    ✓ Peer-reviewed Digital health tools JMIR mental health

    Key finding: Most inpatient users of VR described the experience as pleasant and capable of reducing pain and anxiety. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2016-06-27

    A systematic review of the relationship between behavioral and psychological symptoms (BPSD) and caregiver well-being

    ✓ Peer-reviewed Caregiving International psychogeriatrics

    Key finding: The evidence is not conclusive as to whether some BPSD impact caregiver well-being more than others.

    Full summary, score breakdown and related studies → Original source

  5. 2016-06-26

    Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease

    ✓ Peer-reviewed Drug development BioMed research international

    Key finding: MT chloride (methylene blue) was investigated in a 24-week Phase II clinical trial in 321 patients with mild to moderate AD that failed to show significant positive effects in mild AD patients, although long-term observations (50 weeks) and biomarker studies suggested possible benefit. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2016-06-26

    A multiple hold-out framework for Sparse Partial Least Squares

    ✓ Peer-reviewed Digital health tools Journal of neuroscience methods

    Key finding: SPLS outperformed PLS, finding statistically significant effects and providing higher correlation values in hold-out data. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2016-06-25

    A blood screening test for Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: The present study creates the first-ever multiethnic referent sample that spans community-based and clinic-based populations for implementation of an AD blood screen.

    Full summary, score breakdown and related studies → Original source

  8. 2016-06-24

    The mTOR signalling cascade: paving new roads to cure neurological disease

    ✓ Peer-reviewed Vascular contributions Nature reviews. Neurology

    Key finding: In line with the positioning of mTOR as a pivotal cell signalling node, altered mTOR activation has been associated with a group of phenotypically diverse neurological disorders.

    Full summary, score breakdown and related studies → Original source

  9. 2016-06-23

    Classification of patients with MCI and AD from healthy controls using directed graph measures of resting-state fMRI

    ✓ Peer-reviewed Digital health tools Behavioural brain research

    Key finding: We also performed a hub node analysis and found that the number of hubs in HC, MCI, and AD were 12, 10, and 9, respectively, suggesting that patients with AD experience disturbance of critical communication areas in their brain network as AD progresses.

    Full summary, score breakdown and related studies → Original source

  10. 2016-06-23

    Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

    Key finding: We previously observed that in CA1 of Down syndrome (DS) patients, the level of SET is increased, and SET is translocated to the cytoplasm and associated with the hyperphosphorylation of tau at ser202/thr205. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2016-06-22

    Ubiquitin-dependent and independent roles of SUMO in proteostasis

    ✓ Peer-reviewed Disease mechanisms American journal of physiology. Cell physiology

    Key finding: Cellular proteomes are continuously undergoing alterations as a result of new production of proteins, protein folding, and degradation of proteins. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2016-06-22

    Brain microbleeds: Epidemiology and clinical implications

    ✓ Peer-reviewed Vascular contributions Neurologia

    Key finding: The prevalence of BMB is highly variable (3%-27% in the general population, 6%-80% in patients with vascular risk factors or vascular disease, and 16%-45% in patients with cognitive impairment). +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2016-06-22

    Mirabegron for the treatment of overactive bladder: cost-effectiveness from US commercial health-plan and Medicare Advantage perspectives

    ✓ Peer-reviewed Health systems and care delivery Journal of Medical Economics

    Key finding: From both commercial and Medicare Advantage perspectives, mirabegron was the most clinically effective treatment, while oxybutynin was the least expensive. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2016-06-22

    Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment European radiology

    Key finding: We included 88 patients with dementia due to AD from the Amsterdam Dementia Cohort. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2016-06-22

    The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

    ✓ Peer-reviewed Lewy body dementia The EMBO journal

    Key finding: Thus, our data identify C9orf72 as a novel Rab1a effector in the regulation of autophagy and indicate that C9orf72 haploinsufficiency and associated reductions in autophagy might be the underlying cause of C9ALS/FTD-associated p62 pathology.

    Full summary, score breakdown and related studies → Original source

  16. 2016-06-21

    Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration

    ✓ Peer-reviewed Risk factors Biochimica et biophysica acta. Molecular basis of disease

    Key finding: These cumulative pleiotropic burdens in mitochondria leads to insulin resistance, increased ROS production; enhanced stress-related enzymes that is directly linked MetS and diabetes in neurodegeneration. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2016-06-21

    Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

    ✓ Peer-reviewed Tau biomarkers Nature communications

    Key finding: Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2016-06-20

    Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers

    ✓ Peer-reviewed Vascular contributions Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: We summarize and review current knowledge and understanding of matrix metalloproteinases in the brain and at the blood-brain barrier in neuroinflammation, multiple sclerosis, cerebral aneurysms, stroke, epilepsy, Alzheimer's disease, Parkinson's disease, and brain cancer. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2016-06-20

    First-in-human, double-blind, placebo-controlled, single-dose escalation study of aducanumab (BIIB037) in mild-to-moderate Alzheimer's disease

    ✓ Peer-reviewed Treatments Alzheimer's & dementia (New York, N. Y.)

    Key finding: In this single-dose study, aducanumab demonstrated an acceptable safety and tolerability profile and linear PK at doses ≤30 mg/kg (clinicaltrials.govNCT01397539). +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2016-06-18

    Exposure to air pollution as a potential contributor to cognitive function, cognitive decline, brain imaging, and dementia: A systematic review of epidemiologic research

    ✓ Peer-reviewed Risk factors Neurotoxicology

    Key finding: We also identified several common challenges. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2016-06-18

    Alzheimer's disease due to loss of function: A new synthesis of the available data

    ✓ Peer-reviewed Biomarkers Progress in neurobiology

    Key finding: This paradigm has been criticized, yet most data suggest that Aβ plays a key role in the disease.

    Full summary, score breakdown and related studies → Original source

  22. 2016-06-17

    Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease?

    ✓ Peer-reviewed Brain scans and imaging Trends in neurosciences

    Key finding: Sleep disruption appears to be a core component of Alzheimer's disease (AD) and its pathophysiology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2016-06-15

    Oxidative stress, protein modification and Alzheimer disease

    ✓ Peer-reviewed Genetics Brain research bulletin

    Key finding: Many hypotheses have been proposed to explain different causes of AD, but the exact mechanisms remain unclear. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2016-06-15

    Tau physiology and pathomechanisms in frontotemporal lobar degeneration

    ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry

    Key finding: Frontotemporal lobar degeneration (FTLD) has been associated with toxic intracellular aggregates of hyperphosphorylated tau (FTLD-tau).

    Full summary, score breakdown and related studies → Original source

  25. 2016-06-15

    Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

    ✓ Peer-reviewed Brain tissue and pathology Journal of neurochemistry

    Key finding: The past decade has seen the discovery of several new FTD-causing genetic mutations and the identification of many of the relevant pathological proteins. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →