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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 14,726–14,750 of 27,380 studies, newest first · page 590 of 1096.

September 2017 25

  1. 2017-09-25

    α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

    ✓ Peer-reviewed Disease mechanisms Nature neuroscience

    Key finding: We found that extracellular aSyn oligomers formed a complex with PrP C that induced the phosphorylation of Fyn kinase via metabotropic glutamate receptors 5 (mGluR5). aSyn engagement of PrP C and Fyn activated NMDA receptor (NMDAR) and altered calcium homeostasis.

    Full summary, score breakdown and related studies → Original source

  2. 2017-09-22

    The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid

    ✓ Peer-reviewed Disease mechanisms Nutrients

    Key finding: Further analysis on CSF revealed that a total of 22 subjects were affected by Alzheimer's disease (AD), 16 were affected by non-AD related dementia, and 20 were affected by other neurological disorders. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2017-09-22

    Evidence that iron accelerates Alzheimer's pathology: a CSF biomarker study

    ✓ Peer-reviewed Tau biomarkers Journal of neurology, neurosurgery, and psychiatry

    Key finding: In subjects with biomarker-confirmed Alzheimer's pathology, high CSF ferritin (>6.2 ng/mL) was associated with accelerated depreciation of CSF Aβ1-42 (reporting increased plaque formation; p=0.0001). +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2017-09-22

    Atrial fibrillation and cognitive decline in the Framingham Heart Study

    ✓ Peer-reviewed Long-term cohort studies Heart rhythm

    Key finding: There is a paucity of longitudinal research investigating the relations between atrial fibrillation (AF) and domain-specific cognitive performance. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2017-09-22

    Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers

    ✓ Peer-reviewed Tau biomarkers Neurology

    Key finding: We analyzed CSF concentrations of neurogranin, β-amyloid (Aβ42), phosphorylated tau (p-tau), and total tau (t-tau) among 132 neurologically normal older adults (mean 64.5, range 55-85), along with bilateral hippocampal volumes and a measure of episodic memory (Auditory Verbal Learning Test, delayed recall). +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2017-09-22

    Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

    ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: ApoE4-CLEAR interactions may account for suppressed autophagy in APOE ɛ4/ɛ4 carriers and, in this way, contribute to earlier AD onset.

    Full summary, score breakdown and related studies → Original source

  7. 2017-09-21

    The role of the immune system in Alzheimer disease: Etiology and treatment

    ✓ Peer-reviewed Inflammation and the immune system Ageing research reviews

    Key finding: This review seeks to demonstrate how various aspects of the immune system, both in the brain and peripherally, interact to contribute to AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2017-09-21

    Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study

    ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Obesity (BMI ≥30 kg/m 2 ) at age 50 years (hazard ratio = 1.93; 1.35-2.75) but not at 60 or 70 years was associated with risk of dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2017-09-20

    Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

    ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

    Key finding: Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2017-09-20

    Serum magnesium is associated with the risk of dementia

    ✓ Peer-reviewed Long-term cohort studies Neurology

    Key finding: Within the prospective population-based Rotterdam Study, we measured serum magnesium levels in 9,569 participants, free from dementia at baseline (1997-2008). +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2017-09-20

    ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

    ✓ Peer-reviewed Genetics Nature

    Key finding: By generating P301S tau transgenic mice on either a human ApoE knock-in (KI) or ApoE knockout (KO) background, here we show that P301S/E4 mice have significantly higher tau levels in the brain and a greater extent of somatodendritic tau redistribution by three months of age compared with P301S/E2, P301S/E3, and P301S/EKO mice. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2017-09-19

    Positive Psychosocial Factors and Cognition in Ethnically Diverse Older Adults

    ✓ Peer-reviewed Disparities Journal of the International Neuropsychological Society : JINS

    Key finding: Positive associations between self-efficacy and language did not significantly differ across race/ethnicity, although the bivariate association between self-efficacy and language was not significant among Hispanics. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2017-09-18

    PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)

    ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer s Disease

    Key finding: All amyloid negative subjects imaged were tau-negative. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2017-09-18

    Living and dying with advanced dementia: A prospective cohort study of symptoms, service use and care at the end of life

    ✓ Peer-reviewed End-of-life care Palliative medicine

    Key finding: People with advanced dementia lived with distressing symptoms. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2017-09-18

    A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease

    ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Early expression disturbance of hub genes is an important feature of AD development, and interfering with this process may reverse the disease progression.

    Full summary, score breakdown and related studies → Original source

  16. 2017-09-18

    ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

    ✓ Peer-reviewed TREM2 and immune genetics Neuroscience letters

    Key finding: TREM2 plays a role in phagocytosis, regulates release of cytokine, contributes to microglia maintenance, and its ectodomain is shed from the cell surface. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2017-09-17

    Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

    ✓ Peer-reviewed Risk factors The Lancet. Neurology

    Key finding: The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2017-09-15

    Detecting Dementia Through Interactive Computer Avatars

    ✓ Peer-reviewed Digital health tools IEEE journal of translational engineering in health and medicine

    Key finding: We concluded that our system has the potential to detect dementia through spoken dialog systems and that the system can assist health care workers. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2017-09-15

    Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)

    ✓ Peer-reviewed Brain scans and imaging Diabetes care

    Key finding: More-severe diabetes (defined by higher HbA 1c and longer disease duration) but not prediabetes or less-severe diabetes was associated with smaller brain volumes and an increased burden of brain vascular pathology. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2017-09-14

    Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

    ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Previously, we showed that replacing endogenous p35 with the noncleavable mutant p35 (Δp35) attenuated amyloidosis and improved cognitive function in a familial Alzheimer's disease mouse model. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2017-09-13

    Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer's Disease

    ✓ Peer-reviewed Vascular contributions International journal of molecular sciences

    Key finding: Although further clinical studies should clarify whether BBB disruption is a specific feature of AD pathogenesis, increasing evidence indicates that each component of the neurovascular unit is significantly affected in the presence of AD-related pathologies in animal models and human patients. +2 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2017-09-13

    Exposure to ambient air pollution and the incidence of dementia: A population-based cohort study

    ✓ Peer-reviewed Getting a diagnosis Environment international

    Key finding: In this large cohort, exposure to air pollution, even at the relative low levels, was associated with higher dementia incidence. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2017-09-13

    Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria

    ✓ Peer-reviewed Prevention and risk International psychogeriatrics

    Key finding: Affective symptoms are of prognostic utility, but interventions to prevent dementia syndromes are limited.

    Full summary, score breakdown and related studies → Original source

  24. 2017-09-12

    A Systematic Review of Dementia-related Stigma Research: Can We Move the Stigma Dial?

    ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: Stigma impedes help-seeking and treatment, and occurs broadly and world wide. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2017-09-12

    Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis

    ✓ Peer-reviewed Prevention trials Ageing research reviews

    Key finding: This meta-analysis aims to quantify the overall effect of these interventions on global cognitive functioning in older adults with MCI or dementia.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →