Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 14,801–14,825 of 27,380 studies, newest first · page 593 of 1096.
August 2017 25
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2017-08-28
End-of-life care for advanced dementia patients in residential care home-a Hong Kong perspective
39/100 ✓ Peer-reviewed Health systems and care delivery Annals of palliative medicine
Key finding: In the program, advance care planning (ACP), Do Not Attempt Cardiopulmonary Resuscitation (DNACPR) (non-hospitalized) order will be established and the program will be expected to cover all clusters in Hong Kong by 2018/2019. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-28
Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging
41/100 ✓ Peer-reviewed Genetics Nature neuroscience
Key finding: Under homeostatic conditions, we found that neocortical resident microglia were long-lived, with a median lifetime of well over 15 months; thus, approximately half of these cells survive the entire mouse lifespan.
Full summary, score breakdown and related studies → Original source
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2017-08-26
Dementia and fragility fractures: Issues and solutions
39/100 ✓ Peer-reviewed Costs and economics Injury
Key finding: Dementia and fragility fractures are two conditions that pose significant morbidity and mortality to the elderly population. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-26
The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice
41/100 ✓ Peer-reviewed Drug development Journal of neurology, neurosurgery, and psychiatry
Key finding: The inadvertent development of CAA-like pathology in patients treated with amyloid-beta immunotherapy for Alzheimer's disease has highlighted the importance of establishing how and why CAA develops; without this information, the use of these treatments may be unnecessarily restricted. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-25
Association of Lithium in Drinking Water With the Incidence of Dementia
71/100 ✓ Peer-reviewed Drug development JAMA Psychiatry
Key finding: A total of 73 731 patients with dementia and 733 653 controls (median age, 80.3 years; interquartile range, 74.9-84.6 years; 44 760 female [60.7%] and 28 971 male [39.3%]) were included in the study. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-25
Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain
50/100 ✓ Peer-reviewed Disparities Scientific reports
Key finding: We found a diversity of Aβ peptides, with 26 unique proteoforms including various N- and C-terminal truncations.
Full summary, score breakdown and related studies → Original source
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2017-08-24
Anti-Amyloid-β Monoclonal Antibodies for Alzheimer's Disease: Pitfalls and Promise
41/100 ✓ Peer-reviewed Treatments Biological psychiatry
Key finding: Although testing of mAbs has been fraught with failure and confusing results, the experience gained from these trials has provided important clues for better treatments.
Full summary, score breakdown and related studies → Original source
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2017-08-23
Sleep architecture and the risk of incident dementia in the community
56/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-22
Predictors of emergency department attendance by people with dementia in their last year of life: Retrospective cohort study using linked clinical and administrative data
71/100 ✓ Peer-reviewed End-of-life care Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: ED attendance in the last year of life for people with dementia is common and is increasing. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-08-21
Genetics of Alzheimer's Disease: the Importance of Polygenic and Epistatic Components
39/100 ✓ Peer-reviewed Genetics Current neurology and neuroscience reports
Key finding: We aimed to summarize the recent advances in genetic findings of Alzheimer's disease (AD), focusing on traditional single-marker and gene approaches and non-traditional ones, i.e., polygenic and epistatic components. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-19
Trauma, PTSD, and the Developing Brain
48/100 ✓ Peer-reviewed Hippocampus size on brain scans Current psychiatry reports
Key finding: PTSD in youth is common and debilitating.
Full summary, score breakdown and related studies → Original source
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2017-08-19
Intradialytic Cognitive and Exercise Training May Preserve Cognitive Function
69/100 ✓ Peer-reviewed Prevention trials Kidney international reports
Key finding: Preliminary findings of our pilot study suggested that cognitive decline in psychomotor speed and executive function is possibly prevented by intradialytic CT and ET. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-19
Adherence to the 2015 Dutch dietary guidelines and risk of non-communicable diseases and mortality in the Rotterdam Study
64/100 ✓ Peer-reviewed Prevention and risk European journal of epidemiology
Key finding: Using Cox proportional-hazards models adjusted for confounders, we observed every additional component adhered to was associated with a 3% lower mortality risk (HR 0.97, 95% CI 0.95; 0.98), lower risk of stroke (HR 0.95, 95% CI 0.92; 0.99), chronic obstructive pulmonary disease (HR 0.94, 95% CI 0.91; 0.98), colorectal cancer (HR 0.90, 95% CI 0.84; 0.96), and depression (HR 0.97, 95% CI 0.95; 0.999), but not with incidence of coronary heart disease, type 2 diabetes, heart failure, lung cancer, breast cancer, or dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-08-18
Systematic Review of Sex-Specific Reporting of Data: Cholinesterase Inhibitor Example
84/100 ✓ Peer-reviewed Treatments Journal of the American Geriatrics Society
Key finding: Thirty-three randomized controlled trials were identified evaluating 15,971 participants (9,103 (57%) female). +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-18
Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults
67/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Simvastatin-related reductions in CSF p-tau 181 concentrations may be modulated by LDL cholesterol. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-17
Long-Term Care Service Trajectories and Their Predictors for Persons Living With Dementia: Results From a Canadian Study
50/100 ✓ Peer-reviewed Health systems and care delivery Journal of aging and health
Key finding: Our results revealed relatively equal reliance on home care (HC) and facility-based residential care (RC) as starting points. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-17
Societal and Family Lifetime Cost of Dementia: Implications for Policy
38/100 ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society
Key finding: Dementia substantially increases lifetime costs of care.
Full summary, score breakdown and related studies → Original source
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2017-08-17
Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease
45/100 ✓ Peer-reviewed Brain scans and imaging JCI insight
Key finding: The geometric distribution and increased burden of retinal amyloid pathology in AD, together with the feasibility to noninvasively detect discrete retinal amyloid deposits in living patients, may lead to a practical approach for large-scale AD diagnosis and monitoring. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-17
Trajectory of Dyspnea and Respiratory Distress among Patients in the Last Month of Life
60/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: Respiratory distress escalated in the last days. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-08-17
Clinical Use and Utility of Amyloid Imaging
44/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: Disclosure of amyloid imaging results is desired by many cognitively impaired subjects and seems to be safe once appropriate education is delivered to the disclosing clinicians. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-08-16
Resveratrol for Alzheimer's disease
46/100 ✓ Peer-reviewed Clinical trials Annals of the New York Academy of Sciences
Key finding: The amyloid hypothesis suggests that the progressive accumulation and deposition of central nervous system (CNS) amyloid with aging is the proximate cause of Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
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2017-08-16
Plasma and cerebrospinal fluid tau and neurofilament concentrations in rapidly progressive neurological syndromes: a neuropathology-based cohort
50/100 ✓ Peer-reviewed Biomarkers European journal of neurology
Key finding: Molecular subtypes of sporadic CJD show different levels of plasma tau. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-08-15
The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system
43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neurochemistry
Key finding: APP was first described as a cell-surface receptor; nevertheless, increasing evidence highlighted APP as a cell adhesion molecule. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-14
Alzheimer's disease genetic risk variants beyond APOE ε4 predict mortality
57/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Higher GRS predicted mortality (hazard ratio = 1.05; 95% confidence interval: 1.00-1.10, P = .04). +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-14
Changes of cerebrospinal fluid Aβ42, t-tau, and p-tau in Parkinson's disease patients with cognitive impairment relative to those with normal cognition: a meta-analysis
52/100 ✓ Peer-reviewed Disease mechanisms Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Key finding: The results showed that CSF Aβ 42 level in PDCI cohort was lower than that in PDNC cohort (pooled Std.MD = -0.44, 95% CI [-0.61, -0.26], p < 0.00001).
Full summary, score breakdown and related studies → Original source
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