Newest studies

Neuroinflammation, Gut Microbiome, and Alzheimer's Disease

39/100 ✓ Peer-reviewed Costs and economics Molecular neurobiology

Key finding: There are also clinical complications in advanced dementia, such as eating problems, infections, which will lead to the decline of patients' life quality, and the rising cost of care for AD to our society. +4 more findings

• Brain Biology

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Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders

41/100 ✓ Peer-reviewed Treatments International journal of biological sciences

Key finding: Phytochemicals from medicinal plants can provide a better and safer alternative to synthetic molecules. +4 more findings

• Treatments

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Age-accelerated cognitive decline in asymptomatic adults with CSF β-amyloid

60/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Compare cognitive and hippocampal volume trajectories in asymptomatic middle-aged and older adults with positive CSF markers of β-amyloid (Aβ) or tau to adults without an Alzheimer disease (AD)-associated biomarker profile. +3 more findings

• Biomarkers

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The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort

59/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia (New York, N. Y.)

Key finding: We describe the first large-scale, potentially label-enabling clinical trial of a preclinical treatment for ADAD. +3 more findings

• Clinical Trials
• Early Stage
• Genetics

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Targeting Early Dementia: Using Lipid Cubic Phase Nanocarriers to Cross the Blood⁻Brain Barrier

39/100 ✓ Peer-reviewed Vascular contributions Biomimetics (Basel, Switzerland)

Key finding: Numerous published studies indicate that the preservation of a healthy cerebrovascular endothelium can be an important therapeutic target.

• Treatments

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Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy

38/100 ✓ Peer-reviewed Drug development Journal of the American Chemical Society

Key finding: Exogenous NSCs treated with the NPs significantly rescue the memory deficits in 2xTg-AD mice.

• Treatments

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The ERICA Score: An MR Imaging-based Visual Scoring System for the Assessment of Entorhinal Cortex Atrophy in Alzheimer Disease

48/100 ✓ Peer-reviewed Biomarkers Radiology

Key finding: An ERICA score of 2 or greater indicates probable AD with high diagnostic accuracy. © RSNA, 2018 Online supplemental material is available for this article. +2 more findings

• Brain Scans

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Machine Learning-based Individual Assessment of Cortical Atrophy Pattern in Alzheimer's Disease Spectrum: Development of the Classifier and Longitudinal Evaluation

62/100 ✓ Peer-reviewed Digital health tools Scientific reports

Key finding: In addition, we validated this similarity measure in two longitudinal cohorts consisting of 79 patients with amnestic-mild cognitive impairment (aMCI) and 27 patients with probable AD dementia. +4 more findings

• Digital Tools

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Association of Atrial Fibrillation With Cognitive Decline and Dementia Over 20 Years: The ARIC-NCS (Atherosclerosis Risk in Communities Neurocognitive Study)

55/100 ✓ Peer-reviewed Disparities Journal of the American Heart Association

Key finding: AF is associated with greater cognitive decline and increased risk of dementia, independent of ischemic stroke. +4 more findings

• Risk Factors

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Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay

41/100 ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences of the United States of America

Key finding: Because many cases of FTD result from GRN nonsense mutations, an animal model for this type of mutation is highly desirable for understanding pathogenesis and testing therapies. +2 more findings

• Treatments
• Other Dementias
• Brain Biology

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Impaired Quality of Life and Need for Palliative Care in a German Cohort of Advanced Parkinson's Disease Patients

48/100 ✓ Peer-reviewed End-of-life care Frontiers in neurology

Key finding: Quality of life is dramatically affected in advanced PD patients. +2 more findings

• End-of-Life Care
• Other Dementias

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The challenge of opt-outs from NHS data: a small-area perspective

43/100 ✓ Peer-reviewed Risk factors Journal of Public Health

Key finding: As a result, NHS data provide a huge and invaluable resource of routinely collected primary (e.g. visits to GP practices) and secondary (e.g. hospital admissions, outpatient appointments, A&E attendances) healthcare data covering near-100% of the population of England. +4 more findings

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TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues

46/100 ✓ Peer-reviewed Brain tissue and pathology The Journal of biological chemistry

Key finding: Some intrinsically disordered proteins mediate membraneless organelle formation through liquid-liquid phase separation (LLPS). +3 more findings

• Brain Biology

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Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians

54/100 ✓ Peer-reviewed Caregiving Annals of internal medicine

Key finding: The AGREE II (Appraisal of Guidelines for Research and Evaluation II) instrument was used to evaluate the guidelines. +4 more findings

• Treatments
• Risk Factors

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Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?

53/100 ✓ Peer-reviewed Getting a diagnosis BMC medicine

Key finding: Intravitam PET and postmortem studies have revealed a more pronounced cortical atrophy, elevated cortical and limbic Lewy body pathologies, higher Aβ and tau loads in cortex and striatum in DLB compared to PDD, and earlier cognitive defects in DLB. +1 more finding

• Other Dementias

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Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease

39/100 ✓ Peer-reviewed Biomarkers Neurobiology of disease

Key finding: These findings indicate that NP1 may represent a potential synapse-derived plasma biomarker relevant to early alterations in excitatory synapses in MCI and early-stage AD.

• Biomarkers
• Brain Biology
• Early Stage

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Hypertension-Induced Cerebral Small Vessel Disease Leading to Cognitive Impairment

39/100 ✓ Peer-reviewed Vascular contributions Chinese medical journal

Key finding: In recent years, studies have demonstrated that hypertension-related changes (e.g., small vascular lesions, inflammatory reactions, hypoperfusion, oxidative stress, damage to autoregulatory processes and the blood-brain barrier, and cerebral amyloid angiopathy) can occur over time in cerebral small vessels, potentially leading to lower cognitive function when blood pressure (BP) control is poor or lacking. +4 more findings

• Risk Factors
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review

41/100 ✓ Peer-reviewed Risk factors Frontiers in neuroscience

Key finding: The peripheral and central hearing alterations associated with age-related hearing loss have a profound impact on perception of verbal and non-verbal auditory stimuli.

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A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease

38/100 ✓ Peer-reviewed Drug development Hippocampus

Key finding: We found that the chronic treatment with the triagonist could improve long-term spatial memory of 3xTg-AD mice in Morris water maze, as well as the working memory in Y maze task. +2 more findings

• Brain Biology

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Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease

41/100 ✓ Peer-reviewed Genetics Nature neuroscience

Key finding: We found that while normal aging leads to H4K16ac enrichment, AD entails dramatic losses of H4K16ac in the proximity of genes linked to aging and AD. +2 more findings

• Genetics

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Underdiagnosis of Dementia: an Observational Study of Patterns in Diagnosis and Awareness in US Older Adults

63/100 ✓ Peer-reviewed Getting a diagnosis Journal of general internal medicine

Key finding: Many older adults living with dementia have not been formally diagnosed. +4 more findings

• Diagnosis
• Health Equity

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Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity

41/100 ✓ Peer-reviewed Drug development Acta neuropathologica

Key finding: We show here that Math2-expressing neurons in the hippocampal Cornu ammonis (CA), a region significantly affected by aSyn pathology in advanced PD and DLB, are highly susceptible to pathological seeding with pre-formed fibrils (PFFs), in contrast to dentate gyrus neurons, which are relatively spared. +2 more findings

• Brain Biology
• Side Effects
• Other Dementias

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The Alzheimer's Disease Home Hospice Knowledge Scale: development, validity and reliability

46/100 ✓ Peer-reviewed End-of-life care International journal of palliative nursing

Key finding: The AD-HHK-S included 28 true/false items assessing 3 areas of knowledge: knowledge about hospice, knowledge about home hospice, and knowledge about home hospice for AD. +4 more findings

• End-of-Life Care

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White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes

41/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica communications

Key finding: However, over the past several years, neuroimaging studies have implicated micro- and macrostructural abnormalities in white matter in the risk and progression of AD, suggesting that in addition to the neuronal pathology characteristic of the disease, white matter degeneration and demyelination may be also important pathophysiological features. +1 more finding

• Brain Biology

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Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging

50/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: CSF biomarkers and amyloid positron emission tomography reflect different aspects of Alzheimer's disease brain pathology, and therefore, less-than-perfect correspondence is expected.

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source