Newest studies

A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromes

59/100 ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry

Key finding: A panel of nine CSF biomarkers was able to differentiate APS from patients with PD and dementia. +1 more finding

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration

45/100 ✓ Peer-reviewed Disease mechanisms Nature

Key finding: RBM3 overexpression, achieved either by boosting endogenous levels through hypothermia before the loss of the RBM3 response or by lentiviral delivery, resulted in sustained synaptic protection in 5XFAD mice and throughout the course of prion disease, preventing behavioural deficits and neuronal loss and significantly prolonging survival.

• Brain Biology
• Prevention

Full summary, score breakdown and related studies → Original source

Obstructive sleep apnea in young infants with Down Syndrome evaluated in a Down Syndrome specialty clinic

45/100 ✓ Peer-reviewed Risk factors American Journal of Medical Genetics Part A

Key finding: The minimum overall prevalence of OSA among the larger group of infants was 31% (56/177). +3 more findings

• Down Syndrome

Full summary, score breakdown and related studies → Original source

ApoE Type 4 Allele Affects Cognitive Function of Aged Population in Tianjin City, China

45/100 ✓ Peer-reviewed Genetics American Journal of Alzheimer's Disease & Other Dementias®

Key finding: The results indicate that ApoE∊4 has significant negative effect on the cognitive function of the elderly people who are 60 years and older.

• Genetics

Full summary, score breakdown and related studies → Original source

Neuropsychiatric symptoms in Parkinson's disease dementia are associated with increased caregiver burden

41/100 ✓ Peer-reviewed Caregiving Journal of movement disorders

Key finding: All but one patient showed one or more neuropsychiatric symptoms. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Neuropsychiatric symptoms as predictors of progression to severe Alzheimer's dementia and death: the Cache County Dementia Progression Study

52/100 ✓ Peer-reviewed Clinical safety The American journal of psychiatry

Key finding: Specific neuropsychiatric symptoms are associated with shorter survival time from mild Alzheimer's dementia to severe dementia and/or death. +4 more findings

Full summary, score breakdown and related studies → Original source

Crosstalk between advanced glycation end products (AGEs)-receptor RAGE axis and dipeptidyl peptidase-4-incretin system in diabetic vascular complications

40/100 ✓ Peer-reviewed Drug development Cardiovascular diabetology

Key finding: Indeed, accumulating evidence has suggested the active involvement of accumulation of AGEs in diabetes-associated disorders such as diabetic microangiopathy, atherosclerotic cardiovascular diseases, Alzheimer's disease and osteoporosis. +4 more findings

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

A major role for cardiovascular burden in age-related cognitive decline

50/100 ✓ Peer-reviewed Caregiving Nature reviews. Cardiology

Key finding: Mixed dementia, resulting from both cerebrovascular lesions and neurodegeneration, accounts for the majority of dementia cases among very old individuals (≥75 years). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Plasma levels of apolipoprotein E and risk of dementia in the general population

59/100 ✓ Peer-reviewed Genetics Annals of neurology

Key finding: Low plasma levels of apoE are associated with increased risk of future Alzheimer disease and all dementia in the general population, independent of ε2/ε3/ε4 APOE genotype. +2 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Regulator of G‐protein signalling 5 protects against atherosclerosis in apolipoprotein E‐deficient mice

36/100 ✓ Peer-reviewed Genetics British Journal of Pharmacology

Key finding: Atherosclerotic phenotypes were significantly accelerated in RGS 5 −/− ApoE −/− mice, as indicated by increased inflammatory mediator expression and apoptosis of endothelial cells and macrophages. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Geographical Variation in Dementia

54/100 ✓ Peer-reviewed Risk factors Epidemiology

Key finding: We found a 2- to 3-fold geographical variation in dementia odds in Sweden, after twin random effects-likely to capture genetic and shared environmental variance-were removed. +4 more findings

Full summary, score breakdown and related studies → Original source

Personality and Cognitive Decline in Older Adults: Data From a Longitudinal Sample and Meta-Analysis

69/100 ✓ Peer-reviewed Prevention and risk The journals of gerontology. Series B, Psychological sciences and social sciences

Key finding: Personality is associated with cognitive decline in older adults, with effects comparable to established clinical and lifestyle risk factors. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Do statins impair cognition? A systematic review and meta-analysis of randomized controlled trials

76/100 ✓ Peer-reviewed Drug development Journal of general internal medicine

Key finding: Statin therapy was not associated with cognitive impairment in RCTs. +4 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies

36/100 ✓ Peer-reviewed Drug development Biological psychiatry

Key finding: In addition to the deposition of tau oligomers, our results also provide compelling evidence of co-occurrence of α-synuclein and tau into their most toxic forms, i.e., oligomers suggesting that these species interact and influence each other's aggregation via an interface in synucleinopathies. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Palliative care and quality of life for people with dementia: medical and psychosocial interventions

36/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics

Key finding: Educating families and professionals about palliative care is important as many professionals and non-professionals believe that this approach intends to hasten death, instead of affirming life and regarding dying as a normal process. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Autonomous unobtrusive detection of mild cognitive impairment in older adults

48/100 ✓ Peer-reviewed Digital health tools IEEE transactions on bio-medical engineering

Key finding: Using the sensor and clinical data pertaining to 97 subjects, acquired over an average period of three years, a number of measures associated with the subjects' walking speed and general activity in the home were calculated.

• Digital Tools
• Early Stage

Full summary, score breakdown and related studies → Original source

Relationship between white matter hyperintensities, cortical thickness, and cognition

52/100 ✓ Peer-reviewed Vascular contributions Stroke

Key finding: These cross-sectional results suggest that cortical changes (regional-specific damage and network breakdown), mediated (in)directly by WMH (tract-specific damage) and other factors (eg, vascular risk factors), might lead to cognitive decline. +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

The Link Between Physical Activity and Cognitive Dysfunction in Alzheimer Disease

45/100 ✓ Peer-reviewed Prevention trials Physical therapy

Key finding: Most of the studies suggested that PA attenuates neuropathology and positively affects cognitive function in AD. +1 more finding

• Lifestyle

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The Association Between Serum ApoE Genetic Polymorphism and Serum Lipid Level in Hemodialysis Patients

59/100 ✓ Peer-reviewed Genetics Genetic Testing and Molecular Biomarkers

Key finding: Growing evidence indicates that apolipoprotein E (ApoE) is one of the most important candidate genes for influencing the development of hemodialysis (HD). +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's Disease

38/100 ✓ Peer-reviewed Disease mechanisms Molecular neurobiology

Key finding: An impaired ubiquitin-proteasome system (UPS) could lead to negative consequences for protein regulation, including loss of function. +4 more findings

• Brain Biology

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Dementia praecox redux: a systematic review of the nicotinic receptor as a target for cognitive symptoms of schizophrenia

57/100 ✓ Peer-reviewed Prevention trials Journal of psychopharmacology (Oxford, England)

Key finding: Overall data are underwhelming: some studies showed significant improvements in cognition but as many studies had negative findings.

Full summary, score breakdown and related studies → Original source

Mild cognitive impairment with suspected nonamyloid pathology (SNAP): Prediction of progression

56/100 ✓ Peer-reviewed Genetics Neurology

Key finding: The proportion of progressors was 11% (8/41), 34% (14/41), 56% (19/34), and 71% (60/85) in A-N-, A+N-, SNAP, and A+N+, respectively; the proportion of APOE ε4 carriers was 29%, 70%, 31%, and 71%, respectively, with the SNAP group featuring a significantly different proportion than both A+N- and A+N+ groups (p ≤ 0.005). +1 more finding

• Early Stage
• Genetics
• Brain Scans

Full summary, score breakdown and related studies → Original source

Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases

36/100 ✓ Peer-reviewed Disease mechanisms Annual Review of Pharmacology and Toxicology

Key finding: Currently available therapies for adult onset neurodegenerative diseases provide symptomatic relief but do not modify disease progression. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Association of Alzheimer's disease GWAS loci with MRI markers of brain aging

69/100 ✓ Peer-reviewed Genetics Neurobiology of aging

Key finding: In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (p = 0.0054) and CD33 (rs3865444) with smaller intracranial volume (p = 0.0058). +3 more findings

• Genetics
• Brain Scans

Full summary, score breakdown and related studies → Original source

An acetylation switch controls TDP-43 function and aggregation propensity

54/100 ✓ Peer-reviewed Lewy body dementia Nature communications

Key finding: Here, we identify lysine acetylation as a novel post-translational modification controlling TDP-43 function and aggregation. +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source