Newest studies

Microglia in Alzheimer’s disease

56/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of Cell Biology

Proliferation and activation of microglia in the brain, concentrated around amyloid plaques, is a prominent feature of Alzheimer's disease (AD).

• Brain Biology

Full summary, score breakdown and related studies → Original source

Association Between Poor Cognitive Functioning and Risk of Incident Parkinsonism: The Rotterdam Study

55/100 ✓ Peer-reviewed Long-term cohort studies JAMA neurology

Key finding: Cognitive dysfunction is a common feature among patients with parkinsonism, including Parkinson disease (PD). +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Total Tau and Phosphorylated Tau Protein Serum Levels in Patients with Schizophrenia Compared with Controls

37/100 ✓ Peer-reviewed Tau biomarkers The Psychiatric quarterly

Key finding: Although tau and phosphorylated tau (p-Tau) pathology is a hallmark for dementia, few studies were performed in patients of schizophrenia. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Cerebrovascular pathology in Down syndrome and Alzheimer disease

51/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Acta neuropathologica communications

Key finding: Interestingly, atherosclerosis and hypertension are atypical in DS with age, suggesting the lack of these vascular risk factors may be associated with reduced cerebrovascular pathology. +1 more finding

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

The impact of air pollution to central nervous system in children and adults

39/100 ✓ Peer-reviewed Disparities Neuro endocrinology letters

Key finding: All results indicate changes of child behavior and neurodevelopment at the age of 3-9 years, decrease of IQ, increase of Attention Deficit Hyperactivity Disorder (ADHD), decrease of brain-derived neurotrophic factor (BDNF), reduction of left hemisphere white matter. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden

62/100 ✓ Peer-reviewed Caregiving JAMA neurology

Key finding: The following 2 regions for tau burden were identified: the entorhinal cortex, which exhibits early signs of tauopathy, and the inferior temporal region, which is more closely associated with AD-related pathologic mechanisms. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease

63/100 ✓ Peer-reviewed Caregiving Brain : a journal of neurology

Key finding: Neuropathological and in vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the Alzheimer's disease spectrum. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Interpreting Biomarker Results in Individual Patients With Mild Cognitive Impairment in the Alzheimer's Biomarkers in Daily Practice (ABIDE) Project

63/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology

Key finding: Three- and 1-year progression risks were 86% (95% CI, 71%-95%) and 27% (95% CI, 17%-41%) when MRI results were abnormal, 82% (95% CI, 73%-89%) and 26% (95% CI, 20%-33%) when CSF test results were abnormal, and 89% (95% CI, 79%-95%) and 26% (95% CI, 18%-36%) when the results of both tests were abnormal. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Clinicopathological correlations in behavioural variant frontotemporal dementia

67/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

Key finding: Patients with FTLD were distributed between FTLD-tau (34 patients: 10 corticobasal degeneration, nine progressive supranuclear palsy, eight Pick's disease, three frontotemporal dementia with parkinsonism associated with chromosome 17, three unclassifiable tauopathy, and one argyrophilic grain disease); FTLD-TDP (55 patients: nine type A including one with motor neuron disease, 27 type B including 21 with motor neuron disease, eight type C with right temporal lobe presentations, and 11 unclassifiable including eight with motor neuron disease), FTLD-FUS (eight patients), and one patient with FTLD-ubiquitin proteasome system positive inclusions (FTLD-UPS) that stained negatively for tau, TDP-43, and FUS. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Postoperative cognitive dysfunction and dementia: what we need to know and do

44/100 ✓ Peer-reviewed Getting a diagnosis British journal of anaesthesia

Key finding: Preoperative assessment of neurocognitive function and risk factor identification is imperative in order to ascertain the true extent of POCD and any causative link to anaesthesia and surgery. +4 more findings

Full summary, score breakdown and related studies → Original source

Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: US Preventive Services Task Force Recommendation Statement

53/100 ✓ Peer-reviewed Prevention and risk JAMA

Key finding: Although the use of hormone therapy to prevent chronic conditions in postmenopausal women is associated with some benefits, there are also well-documented harms. +2 more findings

• Prevention
• Treatments

Full summary, score breakdown and related studies → Original source

Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link

44/100 ✓ Peer-reviewed Prevention and risk Frontiers in aging neuroscience

Key finding: Emerging evidence suggests that the integrity of blood-brain barrier (BBB) is central to the onset and progression of neurodegeneration and cognitive impairment. +4 more findings

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

The clinical efficacy of reminiscence therapy in patients with mild-to-moderate Alzheimer disease: Study protocol for a randomized parallel-design controlled trial

54/100 ✓ Peer-reviewed Treatments Medicine

Key finding: Alzheimer disease (AD) is one of the most common diseases among the older adults. +4 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later

70/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Increased levels of triglycerides at midlife predict brain Aβ and tau pathology 20 years later in cognitively healthy individuals. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

52/100 ✓ Peer-reviewed Genetics Neuron

Key finding: Previous studies suggest that reduction of apoE levels through genetic manipulation can reduce Aβ pathology. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics

49/100 ✓ Peer-reviewed Genetics American journal of human genetics

Key finding: Among 50 complex traits with publicly accessible GWAS summary statistics (N total ≈ 4.5 million), we identified more than 170 pairs with statistically significant genetic covariance. +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging

60/100 ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Postmortem data indicate that tau pathology in the transentorhinal cortex is common by age 60, whereas spread to neocortical regions and worsening of cognition is associated with β-amyloid (Aβ). +3 more findings

• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Flortaucipir F 18 Quantitation Using Parametric Estimation of Reference Signal Intensity

56/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: PERSI showed superior test-retest reproducibility (1.84%) and group separation ability (cross-sectional Cohen d = 9.45; longitudinal Cohen d = 2.34) compared with other reference regions. +3 more findings

Full summary, score breakdown and related studies → Original source

Functional connectivity in dementia with Lewy bodies: A within- and between-network analysis

39/100 ✓ Peer-reviewed Brain scans and imaging Human brain mapping

Key finding: We investigated functional connectivity changes in 31 DLB patients compared to 31 healthy controls and a disease comparator group of 29 AD patients using dual regression and FSLNets. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience

41/100 ✓ Peer-reviewed Biomarkers Genome medicine

Key finding: Our results suggest that RAB10 could be a promising therapeutic target for AD prevention. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer's Dementia in Individuals With Previous Depression

59/100 ✓ Peer-reviewed Mild cognitive impairment The American journal of psychiatry

Key finding: Long-term SSRI treatment may delay progression from MCI to Alzheimer's dementia. +2 more findings

• Early Stage
• Treatments

Full summary, score breakdown and related studies → Original source

Performance validity testing in neuropsychology: a clinical guide, critical review, and update on a rapidly evolving literature

40/100 ✓ Peer-reviewed Disparities The Clinical neuropsychologist

Key finding: PVTs provide valuable information regarding response bias and, under the right circumstances, can provide excellent evidence of response bias.

Full summary, score breakdown and related studies → Original source

Marriage and risk of dementia: systematic review and meta-analysis of observational studies

71/100 ✓ Peer-reviewed Prevention and risk Journal of neurology, neurosurgery, and psychiatry

Key finding: Being married is associated with reduced risk of dementia than widowed and lifelong single people, who are also underdiagnosed in routine clinical practice. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Palliative Care for Dementia

39/100 ✓ Peer-reviewed End-of-life care The Psychiatric clinics of North America

Key finding: With the growing care needs for the older population at the end of their lives, there has been a substantial increase in attention to the management of the patient with dementia in hospice and palliative care services. +3 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Arterial stiffness, cognitive impairment and dementia: confounding factor or real risk?

39/100 ✓ Peer-reviewed Risk factors Journal of neurochemistry

Key finding: Therefore, the question remains: is arterial stiffness a true risk for cognitive decline? +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source