Newest studies

Real-world applicability of glial fibrillary acidic protein and neurofilament light chain in Alzheimer's disease

59/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: We constructed a panel combining plasma NfL and GFAP with known AD risk factors (Combination panel: age+sex+APOE4+GFAP+NfL). +4 more findings

• Biomarkers

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Leisure-time sedentary behaviors are differentially associated with all-cause dementia regardless of engagement in physical activity

58/100 ✓ Peer-reviewed Long-term cohort studies Proceedings of the National Academy of Sciences of the United States of America

Key finding: This study investigates whether SB is associated with incident dementia regardless of engagement in physical activity (PA). +3 more findings

• Lifestyle

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Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study

56/100 ✓ Peer-reviewed Digital health tools The lancet. Healthy longevity

Key finding: Between May 28, 2015, and Jan 10, 2018, 502 individuals were assessed as part of Insight 46. +4 more findings

• Brain Scans

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Neuroinflammation in Alzheimer's Disease: Current Progress in Molecular Signaling and Therapeutics

50/100 ✓ Peer-reviewed Inflammation and the immune system Inflammation

Key finding: It is a major cause of dementia which is increasing exponentially with age. +3 more findings

• Brain Biology

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Psychotropic medication prescribing in assisted living and nursing home residents with dementia after the National Partnership

57/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: We identified 107,931 beneficiaries with ≥1 month as an AL resident and 323,766 beneficiaries with ≥1 month as a LSNH resident with dementia, including 1,923,867 person-months and 4,984,405 person-months, respectively. +4 more findings

• Care Services
• Treatments

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Evaluation of Federal Policy Changes to the Hospice Benefit and Use of Hospice for Persons With ADRD

43/100 ✓ Peer-reviewed Health systems and care delivery JAMA health forum

Key finding: The percentage of new enrollees with an ADRD code dropped significantly during the months of IMPACT passage (-1.42 percentage points; 95% CI, -2.13 to -0.71) and implementation (-1.98 percentage points; 95% CI, -2.70 to -1.26) but rose again during the following months. +2 more findings

• Policy
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Symptomatic and Disease-Modifying Therapy Pipeline for Alzheimer's Disease: Towards a Personalized Polypharmacology Patient-Centered Approach

46/100 ✓ Peer-reviewed Drug development International journal of molecular sciences

Key finding: Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder and the most common form of dementia in the elderly with a long presymptomatic phase. +3 more findings

• Treatments

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Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study

52/100 ✓ Peer-reviewed Risk factors GeroScience

Key finding: Overall, we conclude that risk factors linked to dementia relate differently to cognition and brain health. +4 more findings

• Risk Factors

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Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells

41/100 ✓ Peer-reviewed Drug development Neurotoxicology

Key finding: Diabetes mellitus can result in severe complications, such as neurodegenerative diseases including cognitive impairment and dementia. +4 more findings

• Brain Biology

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Deep-learning retinal vessel calibre measurements and risk of cognitive decline and dementia

54/100 ✓ Peer-reviewed Brain scans and imaging Brain communications

Key finding: In multivariable models, narrower retinal arteriolar calibre (hazard ratio per standard deviation decrease = 1.258, P = 0.008) and wider retinal venular calibre (hazard ratio per standard deviation increase = 1.204, P = 0.037) were associated with increased risk of cognitive decline. +2 more findings

• Risk Factors

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Amyloid PET ordering practices in a memory disorders clinic

48/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (New York, N. Y.)

Key finding: Among 565 veterans, 34.9% of received an amyloid PET scan and 98.0% of these were consistent with appropriate use criteria. +4 more findings

• Brain Scans

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Home-Based Transcranial Direct Current Stimulation to Enhance Cognition in Stroke: Randomized Controlled Trial

76/100 ✓ Peer-reviewed Prevention trials Stroke

Key finding: RS-tDCS is a safe and feasible rehabilitation modality for poststroke cognitive dysfunction. +2 more findings

• Clinical Trials
• Diagnosis

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The Role of Obesity and Diabetes in Dementia

43/100 ✓ Peer-reviewed Prevention trials International journal of molecular sciences

Key finding: These conditions share a similar origin through the components of increasing age, gender, genetic and epigenetic predispositions, depression, and a high-fat Western diet (WD) that all contribute to the inflammatory state associated with the development of obesity, diabetes, and dementia. +1 more finding

• Risk Factors
• Lifestyle

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Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients

70/100 ✓ Peer-reviewed Getting a diagnosis The lancet. Psychiatry

Key finding: This analysis of 2-year retrospective cohort studies of individuals diagnosed with COVID-19 showed that the increased incidence of mood and anxiety disorders was transient, with no overall excess of these diagnoses compared with other respiratory infections. +4 more findings

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Independent replication of advanced brain age in mild cognitive impairment and dementia: detection of future cognitive dysfunction

54/100 ✓ Peer-reviewed Digital health tools Molecular psychiatry

Key finding: We found that our pretrained brain age model was able to reliably estimate brain age (mean absolute error = 5.68 years, r(650) = 0.47, age range = 49-89 year) in the sample with 71 participants with subjective cognitive decline (SCD), 375 with mild cognitive impairment (MCI), and 204 with dementia. +2 more findings

• Early Stage
• Brain Scans

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Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

54/100 ✓ Peer-reviewed Genetics Immunity

Key finding: The apolipoprotein E4 (APOE4) allele is associated with an increased risk of Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms remain poorly understood. +2 more findings

• Brain Biology
• Genetics
• Prevention

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Circadian dysfunction and Alzheimer's disease - An updated review

41/100 ✓ Peer-reviewed Risk factors Aging medicine (Milton (N.S.W))

Key finding: Conclusively, the center of this review is primarily based on the principal mechanistic complexities associated with circadian rhythm disruption, sleep deprivation, and AD, and it also emphasizes the potential therapeutic strategies to treat and prevent the progression of AD.

• Brain Biology

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The AHEAD 3-45 Study: Design of a prevention trial for Alzheimer's disease

50/100 ✓ Peer-reviewed Disease mechanisms Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Eligibility to randomize into the A3 Trial or A45 Trial is based on the screening PET imaging results. +2 more findings

• Clinical Trials
• Prevention

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Plasma metabolomic profiles of dementia: a prospective study of 110,655 participants in the UK Biobank

57/100 ✓ Peer-reviewed Long-term cohort studies BMC medicine

Key finding: Plasma metabolomic profile is disturbed in dementia patients, but previous studies have discordant conclusions. +3 more findings

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ER stress and UPR in Alzheimer's disease: mechanisms, pathogenesis, treatments

54/100 ✓ Peer-reviewed Caregiving Cell death & disease

Key finding: Although many efforts have centered on the toxic forms of Aβ to effectively tackle AD, considering the unsatisfactory results so far it is vital to examine other targets and therapeutic approaches as well. +1 more finding

• Treatments

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Cerebral small vessel disease: Pathological mechanisms and potential therapeutic targets

41/100 ✓ Peer-reviewed Vascular contributions Frontiers in aging neuroscience

Key finding: The most widely accepted approach to CSVD treatment is to mitigate vascular risk factors and adopt a healthier lifestyle. +4 more findings

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Faecal microbiota transplant ameliorates gut dysbiosis and cognitive deficits in Huntington's disease mice

45/100 ✓ Peer-reviewed Disease mechanisms Brain communications

Key finding: In Huntington's disease male mice, we revealed an inefficiency of FMT engraftment, which is potentially due to the more pronounced changes in the structure, composition and instability of the gut microbial community, and the imbalance in acetate and gut immune profiles found in these mice. +1 more finding

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Can a serious game-based cognitive training attenuate cognitive decline related to Alzheimer's disease? Protocol for a randomized controlled trial

79/100 ✓ Peer-reviewed Cognitive tests and assessment BMC psychiatry

Key finding: The present study will address several shortcomings of previous CCT studies. +4 more findings

• Clinical Trials

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Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions

40/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuron

Key finding: Here, we show that the mechano-gated Piezo1 channel is expressed in the exploratory processes of astrocytes and utilizes its mechanosensitivity to mediate mechanically evoked Ca 2+ responses and ATP release, establishing Piezo1-mediated mechano-chemo transduction in astrocytes. +4 more findings

• Brain Biology

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057 Dementia and sociodemographic factors a review

28/100 ✓ Peer-reviewed Risk factors Journal of Neurology Neurosurgery & Psychiatry

Key finding: Better understanding of sociodemographic factors of our patient group is key to improving equity of care.

Full summary, score breakdown and related studies → Original source