Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,426–15,450 of 27,380 studies, newest first · page 618 of 1096.
January 2017 25
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2017-01-05
Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria
54/100 ✓ Peer-reviewed Getting a diagnosis Amyotrophic lateral sclerosis & frontotemporal degeneration
Key finding: When present, these deficits significantly and adversely impact patient survival.
Full summary, score breakdown and related studies → Original source
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2017-01-04
Assessing Palliative Care Content in Dementia Care Guidelines: A Systematic Review
66/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: The lack of content surrounding grief represents a gap for this population at high risk for complicated grief and chronic sorrow. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-04
Palliative care during the final week of life of older people in nursing homes: A register-based study
41/100 ✓ Peer-reviewed End-of-life care Palliative & supportive care
Key finding: The most common underlying causes of death among the 49,172 deceased nursing home residents were circulatory diseases (42.2%) and dementia (22.7%). +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-03
Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease
70/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neuroinflammation
Key finding: These data suggest that resveratrol decreases CSF MMP9, modulates neuro-inflammation, and induces adaptive immunity. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-03
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation
38/100 ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences of the United States of America
Key finding: Alzheimer's disease (AD) and other neurodegenerative disorders are associated with the cytoplasmic aggregation of microtubule-associated protein tau. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-03
Calcium Hypothesis of Alzheimer's disease and brain aging: A framework for integrating new evidence into a comprehensive theory of pathogenesis
41/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This article updates the Calcium Hypothesis of Alzheimer's disease and brain aging on the basis of emerging evidence since 1994 (The present article, with the subtitle "New evidence for a central role of Ca 2+ in neurodegeneration," includes three appendices that provide context and further explanations for the rationale for the revisions in the updated hypothesis-the three appendices are as follows: Appendix I "Emerging concepts on potential pathogenic roles of [Ca 2+ ]," Appendix II "Future studies to validate the central role of dysregulated [Ca 2+ ] in neurodegeneration," and Appendix III "Epilogue: towards a comprehensive hypothesis.") +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-03
The concurrent validity and reliability of the Leg Motion system for measuring ankle dorsiflexion range of motion in older adults
41/100 ✓ Peer-reviewed Cognitive tests and assessment PeerJ
Key finding: Dorsiflexion ROM limitation is associated with ankle injuries, foot pain, lower limb disorders, loss of balance, gait control disorders and fall risk in older adults. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-03
Imaging retina to study dementia and stroke
38/100 ✓ Peer-reviewed Vascular contributions Progress in retinal and eye research
Key finding: The retina - due to its anatomical, embryological and physiological similarities with the brain - offers a unique and accessible "window" to study correlates and consequences of subclinical pathology in the brain. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-03
Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study
62/100 ✓ Peer-reviewed Cognitive tests and assessment Scientific reports
Key finding: Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-03
The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension
54/100 ✓ Peer-reviewed Getting a diagnosis Journal of neurology
Key finding: Neurogenic orthostatic hypotension (nOH) is common in patients with neurodegenerative disorders such as Parkinson's disease, multiple system atrophy, pure autonomic failure, dementia with Lewy bodies, and peripheral neuropathies including amyloid or diabetic neuropathy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-02
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease
39/100 ✓ Peer-reviewed Disease mechanisms Trends in endocrinology and metabolism: TEM
Key finding: As the population ages, neurodegenerative diseases such as Alzheimer's disease (AD) are becoming a significant burden on patients, their families, and health-care systems.
Full summary, score breakdown and related studies → Original source
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2017-01-01
The Potential Public Health Relevance of Social Isolation and Loneliness: Prevalence, Epidemiology, and Risk Factors
16/100 ⚠ Report — not peer-reviewed Risk factors Public Policy & Aging Report
Key finding: News headlines from many nations, including the United States, Germany, Australia, and the United Kingdom, suggest that we are facing a loneliness epidemic (http://www.campaigntoendloneliness.org/loneliness-research, http://www.spiegel.de/international/germany/germany-faces-epidemic-of-lonely-and-isolated-seniors-a-876635.html, https://startsat60.com/health/new-survey-reveals-australias-loneliness-epidemic, http://www.huffingtonpost.com.au/tania-de-jong/loneliness-is-the-global-epidemic-of-our-times), leading to the important question of whether there is evidence to support such a claim and, if so, whether we are facing a public health crisis. +4 more findings
Scored 52 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2017 year only
Drebrin in Alzheimer's Disease
39/100 ✓ Peer-reviewed Disease mechanisms Advances in experimental medicine and biology
Key finding: Strong evidence from human genetics and transgenic mouse models has indicated that amyloid β (Aβ) is part of the etiology and pathogenesis of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017 year only
Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study
48/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Alzheimer's disease : JAD
Key finding: Data of amygdala samples (N = 304) immunostained with two α-synuclein antibodies (clone 42 and clone 5G4) was compared with the previously analyzed LRP and AD pathologies from other brain regions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017 year only
Alpha-synucleinopathies
39/100 ✓ Peer-reviewed Brain tissue and pathology Handbook of clinical neurology
Key finding: Since the 1980s immunohistochemical technique based on the use of antibodies directed to proteins of interest has become a method of choice for neuropathologic diagnosis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01 month only
Depression is linked to dementia in older adults
59/100 ✓ Peer-reviewed Risk factors The Practitioner
Key finding: Depression can be a psychological response to receiving a diagnosis of dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017 year only
Midlife Metabolic Profile and the Risk of Late-Life Cognitive Decline
54/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: Mean fasting glycemia at baseline was significantly higher in moderate-severe CD subgroup (114.6±71.4 mg/dl) than in the normal cognition subgroup (101.2±20.6). +2 more findings
Full summary, score breakdown and related studies → Original source
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2017 year only
Memory Complaints and Cognitive Decline: Data from the GUIDAGE Study1
83/100 ✓ Peer-reviewed Clinical trials Journal of Alzheimer's disease : JAD
Key finding: 1,307 patients with SCD and with CDR = 0 at baseline were included. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017 year only
Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD)
79/100 ✓ Peer-reviewed Clinical trials Journal of Alzheimer's disease : JAD
Key finding: No differences between treated groups and placebo in adverse events or in study completion. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017 year only
Clinical Effects of Tramiprosate in APOE4/4 Homozygous Patients with Mild Alzheimer's Disease Suggest Disease Modification Potential
76/100 ✓ Peer-reviewed Clinical trials The journal of prevention of Alzheimer's disease
Key finding: In APOE4/4 homozygotes receiving 150mg BID tramiprosate, efficacy in the traditional Mild AD patients (MMSE 20-26) was higher than the overall group (MMSE 16-26) and efficacy in the Mild patients (MMSE 22-26) was highest. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017 year only
Clinically Relevant Drug Interactions with Anti-Alzheimer's Drugs
39/100 ✓ Peer-reviewed Treatments CNS & neurological disorders drug targets
Key finding: The major pharmacokinetic interactions identified concerned fluoxetine, paroxetine and ketoconazole when used with galantamine or donepezil. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01 month only
[Memantine as add-on medication to acetylcholinesterase inhibitor therapy for Alzheimer dementia]
68/100 ✓ Peer-reviewed Treatments Der Nervenarzt
Key finding: Recently published meta-analyses and cost-benefit analyses also showed positive results.
Full summary, score breakdown and related studies → Original source
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2017 year only
Exercise Training and Functional Connectivity Changes in Mild Cognitive Impairment and Healthy Elders
39/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD
Key finding: A linear mixed effects model revealed a significant interaction in the right parietal lobe: the MCI group showed increased connectivity while the healthy elders showed decreased connectivity. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017 year only
Functional Disintegration of the Default Mode Network in Prodromal Alzheimer's Disease
39/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD
Key finding: Additional mediation analyses indicated that the RSC enables communication between the hippocampus and DMN regions in HC but none of the other two groups. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017 year only
An easy way to increase confidence in beta-amyloid PET evaluation
39/100 ✓ Peer-reviewed Brain scans and imaging Nuclear medicine review. Central & Eastern Europe
Key finding: Early- and late-phase image fusion displayed with appropriate color tables is presented in three different cases to illustrate the added value of the suggested approach. +2 more findings
Full summary, score breakdown and related studies → Original source
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