Newest studies

Cognitive decline in normal aging and its prevention: a review on non-pharmacological lifestyle strategies

60/100 ✓ Peer-reviewed Prevention trials Clinical interventions in aging

Key finding: The results indicate that non-pharmacological lifestyle intervention activities should be intense and possibly done simultaneously in order to be effective in the prevention of cognitive decline.

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Association between advanced glycation end-products and functional performance in Alzheimer's disease and mixed dementia

50/100 ✓ Peer-reviewed Disease mechanisms International psychogeriatrics

Key finding: This study indicates that high AGE levels could be a contributing factor to impaired mobility but lacks evidence for an association with ADL decline in people with early stage AD or mixed dementia. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Virtual Environment Grocery Store

25/100 ✓ Peer-reviewed Risk factors The Role of Technology in Clinical Neuropsychology

Key finding: While Milner (1963) found that patients with dorsolateral prefrontal lesions had greater difficulty on the WCST than patients with orbitofrontal or nonfrontal lesions, other studies have shown that patients with frontal lobe pathology do not always differ from control subjects on the WCST (Stuss et al., 1983).

Full summary, score breakdown and related studies → Original source

Deaths from Alzheimer’s Disease — United States, 1999–2014

16/100 ⚠ Report — not peer-reviewed Risk factors MMWR Morbidity and Mortality Weekly Report

Key finding: Alzheimer's deaths can be an indicator of paid and unpaid caregiver burden because nearly everyone in the final stages of Alzheimer's needs constant care, regardless of the setting, as the result of functional and cognitive declines (2). +2 more findings

• Caregiving
• Care Services

Scored 43 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Amyotrophic lateral sclerosis

59/100 ✓ Peer-reviewed Lewy body dementia Lancet (London, England)

Key finding: Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in the brain and spinal cord. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome

38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuropathology and applied neurobiology

Key finding: Our observations suggest functional tau disturbance in DS brains during development, rather than axonal loss.

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Targeting Free Radicals in Oxidative Stress-Related Human Diseases

38/100 ✓ Peer-reviewed Disease mechanisms Trends in pharmacological sciences

Key finding: Increased formation of reactive oxygen species (ROS) in cancer cells from oncogenic signaling and/or metabolic disturbances leads to upregulation of cellular antioxidant capacity to maintain ROS levels below a toxic threshold. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Alzheimer's disease drug development pipeline: 2017

52/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia (New York, N. Y.)

Key finding: The AD drug development pipeline has 105 agents divided among phase I, phase II, and phase III. +1 more finding

• Treatments
• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy

50/100 ✓ Peer-reviewed Genetics European journal of human genetics : EJHG

Key finding: Accumulating evidence suggests that genetic variants in the SORL1 gene are associated with Alzheimer disease (AD), but a strategy to identify which variants are pathogenic is lacking. +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Untangling Genetic Risk for Alzheimer's Disease

38/100 ✓ Peer-reviewed Genetics Biological psychiatry

Key finding: These cases are of late onset and likely result from the interaction of many genes and the environment.

• Genetics

Full summary, score breakdown and related studies → Original source

Stress and Loss of Adult Neurogenesis Differentially Reduce Hippocampal Volume

38/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

Key finding: The findings suggest that adult neurogenesis is required to maintain hippocampal volume but is not responsible for stress-induced volume loss. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Emerging amyloid and tau targeting treatments for Alzheimer's disease

39/100 ✓ Peer-reviewed Drug development Expert review of neurotherapeutics

Key finding: There is a significant need for further research targeting the disease at an earlier stage and progress in biomarker and imaging technology are improving the outlook.

• Treatments

Full summary, score breakdown and related studies → Original source

Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

41/100 ✓ Peer-reviewed Drug development Molecular neurodegeneration

Key finding: Although tau has been implicated in diverse neurological diseases, its most pathogenic forms remain to be defined. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

48/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in molecular neuroscience

Key finding: The clearance of proteins depends partly on the permeation of the blood-brain barrier (BBB) or on the exchange of water and soluble contents between the cerebrospinal fluid (CSF) and the interstitial fluid (ISF). +3 more findings

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Dementia and osteoporosis in a geriatric population: Is there a common link?

39/100 ✓ Peer-reviewed Prevention and risk World journal of orthopedics

Key finding: Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. +4 more findings

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Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

38/100 ✓ Peer-reviewed Inflammation and the immune system Nature reviews. Neuroscience

Key finding: Cerebral blood flow (CBF) regulation is essential for normal brain function. +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

Clinical effects of air pollution on the central nervous system; a review

38/100 ✓ Peer-reviewed Risk factors Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Key finding: Air pollution and particulate matter (PM) are associated with neuroinflammation and reactive oxygen species (ROS). +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

How many people will need palliative care in 2040? Past trends, future projections and implications for services

64/100 ✓ Peer-reviewed Getting a diagnosis BMC medicine

Key finding: If recent mortality trends continue, 160,000 more people in England and Wales will need palliative care by 2040. +1 more finding

• End-of-Life Care

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Phase II clinical trials of anti-amyloid β antibodies: When is enough, enough?

43/100 ✓ Peer-reviewed Clinical trials Alzheimer's & dementia (New York, N. Y.)

Key finding: An analysis of publicly available data from the Phase II studies for bapineuzumab and solanezumab indicates that neither compound produced compelling evidence of drug-like behavior that would justify their progression into pivotal trials. +1 more finding

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Tau at the Crossroads between Neurotoxicity and Neuroprotection

39/100 ✓ Peer-reviewed Drug development Neuron

Key finding: (2016) recently showed that specific tau phosphorylation is neuroprotective, phenocopying tau ablation (DeVos et al., 2017), thus highlighting the complex tau biology that underlies neurotoxicity and neuroprotection.

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Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

43/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in neuroscience

Key finding: Evidences indicate that ALS is a non-cell autonomous disease in which glial cells participate in both disease onset and progression. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides

52/100 ✓ Peer-reviewed Risk genes beyond APOE Circulation research

Key finding: Increasing evidence indicates that alterations of the cerebral microcirculation may play a role in Alzheimer disease, the leading cause of late-life dementia. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Mild Cognitive Impairment

43/100 ✓ Peer-reviewed Getting a diagnosis Clinics in geriatric medicine

Key finding: Mild cognitive impairment (MCI) occurs along a continuum from normal cognition to dementia. +4 more findings

• Diagnosis
• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Efficacy and Safety of an Herbal Therapy in Patients with Amnestic Mild Cognitive Impairment: A 24-Week Randomized Phase III Trial

46/100 ✓ Peer-reviewed Treatments Evidence-based complementary and alternative medicine : eCAM

Key finding: Herbal therapy demonstrated a significant improvement in cognition and memory, which were similar to the donepezil in patients with aMCI. +2 more findings

• Treatments
• Clinical Trials
• Side Effects

Full summary, score breakdown and related studies → Original source

Altered Functional Connectivity of Cognitive-Related Cerebellar Subregions in Alzheimer's Disease

39/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in aging neuroscience

Key finding: Compared with the controls, the AD patients showed disrupted rsFCs in several different networks (DMN, VN and SMN), predicting the impairment of the functional integration in the cerebellum. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source