Newest studies

Study protocol: pragmatic randomized control trial of an internet-based intervention (My tools 4 care) for family carers

58/100 ✓ Peer-reviewed Treatments BMC geriatrics

Key finding: Data collection began in Ontario and Alberta Canada in June 2015 and is expected to be completed in June 2017. +4 more findings

• Clinical Trials
• Caregiving

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mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia

45/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Free radical biology & medicine

Key finding: The neuropathology of AD in DS is complex and involves impaired mitochondrial function, defects in neurogenesis, increased oxidative stress, altered proteostasis and autophagy networks as a result of triplication of chromosome 21(chr 21). +2 more findings

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

Tauopathy and cognitive impairment in experimental diabetes mellitus

38/100 ✓ Peer-reviewed Risk factors Diabetes mellitus

Key finding: Patients with DM show an increased risk of developing AD.

• Risk Factors

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Receptors make the pathway choice for protein degradation

39/100 ✓ Peer-reviewed Disease mechanisms Autophagy

Key finding: Damaged or aggregated proteins and organelles accumulate with age and contribute to various age-related pathologies including Alzheimer, Parkinson or Huntington diseases. +3 more findings

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Dementia Caregiver Burden: a Research Update and Critical Analysis

54/100 ✓ Peer-reviewed Getting a diagnosis Current psychiatry reports

Key finding: This article provides an updated review of the determinants of caregiver burden and depression, with a focus on care demands and especially the differential effects of various neuropsychiatric symptoms or symptom clusters. +4 more findings

• Caregiving

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Lessons from Anti-Amyloid-β Immunotherapies in Alzheimer Disease: Aiming at a Moving Target

38/100 ✓ Peer-reviewed Drug development Neuro-degenerative diseases

Key finding: Available drugs for the global Alzheimer disease (AD) epidemic only treat the symptoms without modifying disease progression. +3 more findings

• Treatments

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APOE genotype and early β-amyloid accumulation in older adults without dementia

66/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: APOE ε4 carriage and older age were predictors of longitudinal Aβ accumulation within the Aβ- group but not the Aβ+ group. +4 more findings

• Genetics
• Prevention

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Polygenic risk score analysis of pathologically confirmed Alzheimer disease

59/100 ✓ Peer-reviewed Genetics Annals of neurology

Key finding: We suggest that this analysis has clinical utility and that there is limited room for further improvement using genetic data.

• Genetics

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Mitophagy in neurodegenerative diseases

39/100 ✓ Peer-reviewed Disease mechanisms Neurochemistry international

Key finding: Indeed, their impairment has been reported as associated with the development of these diseases.

• Brain Biology
• Other Dementias

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Association between chronic periodontitis and the risk of Alzheimer's disease: a retrospective, population-based, matched-cohort study

72/100 ✓ Peer-reviewed Costs and economics Alzheimer's research & therapy

Key finding: Our findings demonstrate that 10-year CP exposure was associated with a 1.707-fold increase in the risk of developing AD. +4 more findings

• Risk Factors

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BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease

38/100 ✓ Peer-reviewed Treatments Journal of medicinal chemistry

Key finding: One major target has been the β-site amyloid-precursor-protein-cleaving enzyme 1 (BACE-1), with many big pharma companies expending great resources in the search for BACE-1 inhibitors. +4 more findings

• Treatments

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Level of Care Preferences Among Nursing Home Residents With Advanced Dementia

78/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

Key finding: Most proxies select comfort as the preferred level of care for NH residents with advanced dementia. +4 more findings

• End-of-Life Care
• Clinical Trials
• Care Services

Full summary, score breakdown and related studies → Original source

Effectiveness of advance care planning with family carers in dementia nursing homes: A paired cluster randomized controlled trial

72/100 ✓ Peer-reviewed End-of-life care Palliative medicine

Key finding: Advance care planning was effective in reducing family carer uncertainty in decision-making concerning the care of their family member and improving perceptions of quality of care in nursing homes. +1 more finding

• Clinical Trials
• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity

57/100 ✓ Peer-reviewed Lewy body dementia The EMBO journal

Key finding: Intriguingly, FUS's nearly uncharged, aggregation-prone, yeast prion-like, low sequence-complexity domain (LC) is known to be targeted for phosphorylation. +4 more findings

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Effects of facilitated family case conferencing for advanced dementia: A cluster randomised clinical trial

74/100 ✓ Peer-reviewed End-of-life care PloS one

Key finding: FCC facilitates a palliative approach to care. +2 more findings

• Clinical Trials
• End-of-Life Care
• Caregiving

Full summary, score breakdown and related studies → Original source

Brain perivascular macrophages: characterization and functional roles in health and disease

46/100 ✓ Peer-reviewed Inflammation and the immune system Journal of molecular medicine (Berlin, Germany)

Key finding: PVM migrate from the yolk sac into the brain early in development and, like microglia, are likely to be a self-renewing cell population that, in the normal state, is not replenished by circulating monocytes. +3 more findings

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Eyetracking Metrics in Young Onset Alzheimer's Disease: A Window into Cognitive Visual Functions

48/100 ✓ Peer-reviewed Digital health tools Frontiers in neurology

Key finding: Young onset Alzheimer's disease (YOAD) is defined as symptom onset before the age of 65 years and is particularly associated with phenotypic heterogeneity. +2 more findings

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The Effectiveness of Advance Care Planning in Improving End-of-Life Outcomes for People With Dementia and Their Carers: A Systematic Review and Critical Discussion

72/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

Key finding: There is a need for more high-quality outcome studies, particularly using randomized designs to control for confounding. +1 more finding

• End-of-Life Care
• Caregiving

Full summary, score breakdown and related studies → Original source

Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms

54/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia (New York, N. Y.)

Key finding: Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing substantial distress for both people with dementia and their caregivers, and contributing to early institutionalization. +4 more findings

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Effectiveness of Florbetapir PET Imaging in Changing Patient Management

56/100 ✓ Peer-reviewed Biomarkers Dementia and geriatric cognitive disorders

Key finding: A higher proportion of patients in the immediate feedback arm showed a change in diagnosis compared to the controls (32.6 vs. 6.4%; p = 0.0001). +2 more findings

• Brain Scans

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Brain network efficiency is influenced by the pathologic source of corticobasal syndrome

54/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: In a cross-sectional design, pathology was confirmed by autopsy or a pathologically validated CSF total tau-to-β-amyloid ratio (T-tau/Aβ). +3 more findings

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Smartphone-Based Health Technologies for Dementia Care: Opportunities, Challenges, and Current Practices

38/100 ✓ Peer-reviewed Disparities Journal of applied gerontology : the official journal of the Southern Gerontological Society

Key finding: Most of the 5.4 million people affected by Alzheimer's disease and other forms of dementia (AD) are noninstitutionalized, receiving care by unpaid family caregivers and medically managed by a primary care provider (PCP).

• Digital Tools

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Frequency-Dependent Altered Functional Connections of Default Mode Network in Alzheimer's Disease

39/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in aging neuroscience

Key finding: Alzheimer's disease (AD) is a neurodegenerative disorder associated with the progressive dysfunction of cognitive ability. +4 more findings

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Off-Target 18F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation

48/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: There was an age-related increase in both 18 F-AV-1451 binding in the basal ganglia and R 2 * values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. 18 F-AV-1451 binding in the basal ganglia increased with R 2 * values. +2 more findings

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Recent developments in understanding the role of the gut microbiota in brain health and disease

38/100 ✓ Peer-reviewed Disease mechanisms Annals of the New York Academy of Sciences

Key finding: Additionally, recent preclinical and clinical evidence suggest that targeting the microbiota through prebiotic, probiotic, or dietary interventions may be an effective "psychobiotic" strategy for treating symptoms in mood, neurodevelopmental disorders, and neurodegenerative diseases.

Full summary, score breakdown and related studies → Original source