alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 16,051–16,075 of 27,380 studies, newest first · page 643 of 1096.

May 2016 25

  1. 2016-05-24

    In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

    ✓ Peer-reviewed Drug development Frontiers in aging neuroscience

    Key finding: The PIB binding increased significantly in temporal lobe in placebo and treatment patients (both P = 0.04), and in occipital lobe in treatment patients (P = 0.04). +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2016-05-24

    Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

    ✓ Peer-reviewed Genetics Biological psychiatry

    Key finding: We demonstrate that using additional phenotype data previously collected by genetic studies to tackle phenotypic heterogeneity in MDD can successfully lead to the discovery of genetic risk factor despite reduced sample size. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2016-05-24

    Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed Tau biomarkers Neurobiology of disease

    Key finding: In wild type mice, we show that Aβ40 (fluorescently labeled Aβ40 or unlabeled Aβ40), was distributed from CSF to brain, via the peri-arterial space, and associated with neurons. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2016-05-24

    Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

    ✓ Peer-reviewed Disease mechanisms Mechanisms of ageing and development

    Key finding: It has been shown that insulin resistance impairs glucose metabolism and mitochondrial function, thus increasing production of reactive oxygen species. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2016-05-23

    Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

    ✓ Peer-reviewed Brain tissue and pathology American journal of human genetics

    Key finding: Late-onset, sporadic Alzheimer disease (AD) is a common and lethal neurodegenerative disorder and many germline inherited variants have been found to influence the risk of developing AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2016-05-22

    Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia

    ✓ Peer-reviewed Disease mechanisms Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Our findings suggest that the proposition that synaptic markers can predict cognitive decline in AD, should be extended to Lewy body diseases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2016-05-21

    "New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)

    ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology

    Key finding: After demonstrating the importance of correct disease classification for AD and primary age-related tauopathy, we emphasize the public health impact of an underappreciated AD "mimic," which has been termed "hippocampal sclerosis of aging" or "hippocampal sclerosis dementia."

    Full summary, score breakdown and related studies → Original source

  8. 2016-05-20

    Molecular Mechanisms of Vascular Dementia: What Can Be Learned from Animal Models of Chronic Cerebral Hypoperfusion?

    ✓ Peer-reviewed Inflammation and the immune system Molecular neurobiology

    Key finding: Numerous studies have demonstrated that chronic cerebral hypoperfusion (CCH) is associated with the initiation and progression of VD and Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2016-05-19

    Biomarkers for dementia and mild cognitive impairment in Parkinson's disease

    ✓ Peer-reviewed Mild cognitive impairment Movement disorders : official journal of the Movement Disorder Society

    Key finding: Because it is not currently known which type of mild cognitive impairment confers a higher risk of progression to dementia, it would be useful to define biomarkers that could identify these patients to better study disease progression and possible interventions. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2016-05-18

    Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility

    ✓ Peer-reviewed Genetics European journal of human genetics : EJHG

    Key finding: We have applied the methodology to identify and characterise loci associated with susceptibility to type 2 diabetes (T2D) using GWAS data from the Resource for Genetic Epidemiology on Adult Health and Aging, a large multi-ethnic population-based cohort, created for investigating the genetic and environmental basis of age-related diseases.

    Full summary, score breakdown and related studies → Original source

  11. 2016-05-18

    Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases

    ✓ Peer-reviewed Inflammation and the immune system Journal of controlled release : official journal of the Controlled Release Society

    Key finding: Failure in maintaining any of these components results in the breakdown of this specialized multicellular structure and consequently promotes neuroinflammation and neurodegeneration.

    Full summary, score breakdown and related studies → Original source

  12. 2016-05-18

    A meta-review of stress, coping and interventions in dementia and dementia caregiving

    ✓ Peer-reviewed Caregiving BMC geriatrics

    Key finding: This meta-review supports the conclusion that being a caregiver for people with dementia is associated with psychological stress and physical ill-health. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2016-05-17

    Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice

    ✓ Peer-reviewed Drug development Neurobiology of aging

    Key finding: A crucial mechanism-related safety concern is the exacerbation of microhemorrhages, which are already present in the majority of Alzheimer patients. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2016-05-17

    Genes associated with Alzheimer's disease: an overview and current status

    ✓ Peer-reviewed Caregiving Clinical interventions in aging

    Key finding: Genome-wide association studies have revolutionized genetic research and have identified over 20 genetic loci associated with late-onset AD.

    Full summary, score breakdown and related studies → Original source

  15. 2016-05-17

    ABCA7 frameshift deletion associated with Alzheimer disease in African Americans

    ✓ Peer-reviewed Genetics Neurology. Genetics

    Key finding: This common ABCA7 deletion could represent an ethnic-specific pathogenic alteration in AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2016-05-16

    Risk Factors for Malnutrition in Older Adults: A Systematic Review of the Literature Based on Longitudinal Data

    ✓ Peer-reviewed Clinical safety Advances in nutrition (Bethesda, Md.)

    Key finding: These studies reported the following significant risk factors for malnutrition: age (OR: 1.038; P = 0.045), frailty in institutionalized persons (β: 0.22; P = 0.036), excessive polypharmacy (β: -0.62; P = 0.001), general health decline including physical function (OR: 1.793; P = 0.008), Parkinson disease (OR: 2.450; P = 0.047), constipation (OR: 2.490; P = 0.015), poor (OR: 3.30; P value not given) or moderate (β: -0.27; P = 0.016) self-reported health status, cognitive decline (OR: 1.844; P = 0.001), dementia (OR: 2.139; P = 0.001), eating dependencies (OR: 2.257; P = 0.001), loss of interest in life (β: -0.58; P = 0.017), poor appetite (β: -1.52; P = 0.000), basal oral dysphagia (OR: 2.72; P = 0.010), signs of impaired efficacy of swallowing (OR: 2.73; P = 0.015), and institutionalization (β: -1.89; P < 0.001).

    Full summary, score breakdown and related studies → Original source

  17. 2016-05-14

    BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

    ✓ Peer-reviewed Genetics Human molecular genetics

    Key finding: Our findings provide a mechanistic role of BIN1 in the pathogenesis of AD as a novel genetic regulator of BACE1 levels and Aβ production.

    Full summary, score breakdown and related studies → Original source

  18. 2016-05-13

    Molecular and cellular pathophysiology of preclinical Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Behavioural brain research

    Key finding: We and others have demonstrated that Aβ plaques and NFTs are present in varying degrees before the onset and throughout the progression of dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2016-05-13

    Disrupted Network Topology in Patients with Stable and Progressive Mild Cognitive Impairment and Alzheimer's Disease

    ✓ Peer-reviewed Mild cognitive impairment Cerebral cortex (New York, N.Y. : 1991)

    Key finding: Recent findings suggest that Alzheimer's disease (AD) is a disconnection syndrome characterized by abnormalities in large-scale networks. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2016-05-13

    The Impact of Mild Cognitive Impairment on Gait and Balance: A Systematic Review and Meta-Analysis of Studies Using Instrumented Assessment

    ✓ Peer-reviewed Getting a diagnosis Gerontology

    Key finding: Fourteen studies met the inclusion criteria and reported quantitative gait (n = 11) or postural balance (n = 4) parameters to be included in the meta-analysis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2016-05-13

    Phenotypes of prediabetes and stratification of cardiometabolic risk

    ✓ Peer-reviewed Prevention and risk The lancet. Diabetes & endocrinology

    Key finding: Prediabetes is associated with increased risks of type 2 diabetes, cardiovascular disease, dementia, and cancer, and its prevalence is increasing worldwide.

    Full summary, score breakdown and related studies → Original source

  22. 2016-05-12

    Developing Brain Vital Signs: Initial Framework for Monitoring Brain Function Changes Over Time

    ✓ Peer-reviewed Digital health tools Frontiers in neuroscience

    Key finding: Clinical assessment of brain function relies heavily on indirect behavior-based tests.

    Full summary, score breakdown and related studies → Original source

  23. 2016-05-12

    Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism

    ✓ Peer-reviewed Genetics Arteriosclerosis, thrombosis, and vascular biology

    Key finding: Unlike apoE2 and apoE3, apoE4 has markedly altered CNS metabolism, is associated with Alzheimer disease and other neurodegenerative disorders, and is expressed at lower levels in brain and cerebrospinal fluid.

    Full summary, score breakdown and related studies → Original source

  24. 2016-05-11

    Neuroinflammation in Alzheimer's disease: Current evidence and future directions

    ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Several attempts have been made to treat Alzheimer's disease (AD) using anti-amyloid strategies with disappointing results. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2016-05-11

    Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study

    ✓ Peer-reviewed Long-term cohort studies The Lancet. Neurology

    Key finding: We postulated that cerebral amyloid angiopathy (CAA), characterised by cortical vascular amyloid deposits, is associated with cortical tissue loss independent of parenchymal Alzheimer's disease pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →