Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 14,776–14,800 of 27,380 studies, newest first · page 592 of 1096.
September 2017 14
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2017-09-01
Clinical aspects and biomarkers of Alzheimer's disease in Down syndrome
38/100 ✓ Peer-reviewed Biomarkers Free radical biology & medicine
Key finding: Previous literature suggested some unique features in clinical presentation of dementia in DS (DSd), which might be due to diagnostic difficulties, or represent a real difference compared to SAD or FAD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-09-01
Large Perivascular Spaces Visible on Magnetic Resonance Imaging, Cerebral Small Vessel Disease Progression, and Risk of Dementia: The Age, Gene/Environment Susceptibility-Reykjavik Study
55/100 ✓ Peer-reviewed Vascular contributions JAMA neurology
Key finding: However, whether large perivascular spaces (L-PVSs) (>3 mm in diameter) visible on MRI are associated with SVD and cognitive deterioration in older individuals is unknown. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-09-01
Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
61/100 ✓ Peer-reviewed Risk factors The Lancet
Key finding: Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57·6 million (95% uncertainty interval [UI] 40·8-75·9 million [7·2%, 6·0-8·3]), 45·1 million (29·0-62·8 million [5·6%, 4·0-7·2]), 36·3 million (25·3-50·9 million [4·5%, 3·8-5·3]), 34·7 million (23·0-49·6 million [4·3%, 3·5-5·2]), and 34·1 million (23·5-46·0 million [4·2%, 3·2-5·3]) of total YLDs, respectively. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-09-01
The End of Life Option Act: Important Considerations for Pharmacists as California Implements Physician Aid in Dying
27/100 ✓ Peer-reviewed Health systems and care delivery Journal of Contemporary Pharmacy Practice
Key finding: The law has safeguards intended to ensure that patients are acting autonomously, including a 15-day waiting period between two requests, the requirement that patients meet privately with their physicians to confirm they are acting on their own, and the requirement that patients sign a form within 48 hours of taking the aid-in-dying drug to indicate that it is their choice. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-09-01
Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging
65/100 ✓ Peer-reviewed Tau biomarkers JAMA neurology
Key finding: The utility of plasma total tau level as a prognostic marker for cognitive decline and dementia is not well understood. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-09-01
Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport
56/100 ✓ Peer-reviewed TREM2 and immune genetics JAMA neurology
Key finding: Mutations in APP, PSEN1, and PSEN2 lead to early-onset Alzheimer disease (EOAD) but account for only approximately 11% of EOAD overall, leaving most of the genetic risk for the most severe form of Alzheimer disease unexplained. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-09-01
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
63/100 ✓ Peer-reviewed TREM2 and immune genetics Immunity
Key finding: We identified a specific apolipoprotein E (APOE)-dependent molecular signature in microglia from models of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Alzheimer's disease (AD) and in microglia surrounding neuritic β-amyloid (Aβ)-plaques in the brains of people with AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-09-01
Machine Learning, Sentiment Analysis, and Tweets: An Examination of Alzheimer's Disease Stigma on Twitter
46/100 ✓ Peer-reviewed Digital health tools The journals of gerontology. Series B, Psychological sciences and social sciences
Key finding: This technique could be applied to questions in social gerontology related to how social media outlets reflect and shape attitudes bearing on other developmental outcomes.
Full summary, score breakdown and related studies → Original source
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2017-09-01
Association Between Birth in a High Stroke Mortality State, Race, and Risk of Dementia
63/100 ✓ Peer-reviewed Disparities JAMA neurology
Key finding: Overall, birth in an HSMS was associated with a 28% higher risk of dementia (adjusted hazard ratio [aHR], 1.28; 95% CI, 1.13-1.46) adjusted for age, sex, and race. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-09-01
Behavioural and Psychological Symptoms of Dementia: Correlates and Impact on Caregiver Distress
53/100 ✓ Peer-reviewed Disparities Dementia and geriatric cognitive disorders extra
Key finding: BPSD are universally present, bear correlates with dementia type and severity, and cause significant caregiver distress. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-09-01
Association of Vision Loss With Cognition in Older Adults
60/100 ✓ Peer-reviewed Disparities JAMA ophthalmology
Key finding: Sample weights were used to ensure result generalizability. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-09-01
A systemic view of Alzheimer disease - insights from amyloid-β metabolism beyond the brain
52/100 ✓ Peer-reviewed Getting a diagnosis Nature reviews. Neurology
Key finding: On the basis of these findings, we propose that these abnormal systemic changes might not only develop secondary to brain dysfunction but might also affect AD progression, suggesting that the interactions between the brain and the periphery have a crucial role in the development and progression of AD.
Full summary, score breakdown and related studies → Original source
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2017-09-01
The Health Effects of Aluminum Exposure
47/100 ✓ Peer-reviewed Prevention and risk Deutsches Arzteblatt international
Key finding: Keeping these concentrations below the tolerance values prevents the development of manifest and subclinical signs of aluminum toxicity. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-09-01
Semantic Memory in the Clinical Progression of Alzheimer Disease
55/100 ✓ Peer-reviewed Treatments Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
Key finding: Semantic-lexical retrieval and lexical search may represent distinct aspects of semantic memory.
Full summary, score breakdown and related studies → Original source
August 2017 11
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2017-08-31
Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation
45/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in aging neuroscience
Key finding: It is widely accepted that microglia-mediated inflammation is a significant contributor to disease pathogenesis; however, different microglia phenotypes were identified along AD progression and excessive Aβ production was shown to dysregulate cell function. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-31
Psychosocial behaviour management programme for home-dwelling people with dementia: A cluster-randomized controlled trial
57/100 ✓ Peer-reviewed Treatments International journal of geriatric psychiatry
Key finding: Little is known about the effectiveness of a psychosocial behaviour management programme on home-dwelling people with dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-08-30
Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease
41/100 ✓ Peer-reviewed Risk factors Particle and fibre toxicology
Key finding: Inhalation exposure to DEE causes accelerated plaque formation and motor function impairment in 5XFAD transgenic mice. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-30
Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke
48/100 ✓ Peer-reviewed Biomarkers BMC neurology
Key finding: These findings indicate that although plasma and CSF neurogranin may reflect the volume of acute cerebral ischemia, this synaptic protein is less likely to be a potential AIS biomarker. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-30
Vitamin C Status and Cognitive Function: A Systematic Review
60/100 ✓ Peer-reviewed Cognitive tests and assessment Nutrients
Key finding: This review evaluates the link between vitamin C status and cognitive performance, in both cognitively intact and impaired individuals. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-30
Neuropathology of White Matter Lesions, Blood-Brain Barrier Dysfunction, and Dementia
50/100 ✓ Peer-reviewed Digital health tools Stroke
Key finding: Our data suggest that some degree of blood-brain barrier dysfunction is common in older people and that this may be related to clinical dementia risk, additional to standard MRI biomarkers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-30
Barriers and facilitators in accessing dementia care by ethnic minority groups: a meta-synthesis of qualitative studies
52/100 ✓ Peer-reviewed Disparities BMC psychiatry
Key finding: The two overarching themes lend themselves to interventions at a service level and a community level which need to happen in synergy.
Full summary, score breakdown and related studies → Original source
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2017-08-30
Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging
60/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: As expected, the MENO group was older than the PERI and CNT groups. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-30
DHA-rich n-3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
61/100 ✓ Peer-reviewed Treatments The American journal of clinical nutrition
Key finding: At 6 mo, the n-3 FA group displayed marked increases in DHA and EPA plasma concentrations (2.6- and 3.5-fold), as well as decreased methylation in 2 out of 4 CpG sites ( P < 0.05 for all), respectively. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-30
Categorizing Health Outcomes and Efficacy of mHealth Apps for Persons With Cognitive Impairment: A Systematic Review
64/100 ✓ Peer-reviewed Treatments Journal of medical Internet research
Key finding: After removal of duplicates, our initial search returned 3955 records. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-08-29
Predictors of advance directives among nursing home residents with dementia
50/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics
Key finding: Less than half of the nursing home residents (39.2%) had advance directives and most (96.4%) had been completed by family surrogates. +4 more findings
Full summary, score breakdown and related studies → Original source
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