Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 21,051–21,075 of 27,380 studies, newest first · page 843 of 1096.
January 2010 25
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2010-01-01
A population-based study of cognitive function in older people with subjective memory complaints
50/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: SMC were associated with a number of specific objective cognitive deficits including poor verbal fluency, and poor immediate and delayed recall. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
Visual impairment in Alzheimer's disease: a critical review
36/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: Recent studies have demonstrated the potential of visual interventions to improve the functioning of AD patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
Caffeine and adenosine
36/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: In conclusion, targeting approaches that involve ARs will enhance the possibilities to correct brain dysfunctions, via the universally consumed substance that is caffeine.
Full summary, score breakdown and related studies → Original source
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2010-01-01
Exercise plays a preventive role against Alzheimer's disease
36/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: It is predicted that the incidence of AD will be increased in the future making this disease one of the greatest medical, social, and economic challenges for individuals, families, and the health care system worldwide. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
Regulation of mitochondrial biogenesis
36/100 ✓ Peer-reviewed Prevention trials Essays in biochemistry
Key finding: Mitochondrial dysfunction is an important component of different diseases associated with aging, such as Type 2 diabetes and Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2010-01-01
PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses
75/100 ✓ Peer-reviewed Clinical trials Journal of Alzheimer's disease : JAD
Key finding: A recent Phase IIa double-blind, randomized, placebo-controlled trial found that the 250 mg dose of PBT2 was well-tolerated, significantly lowered cerebrospinal fluid (CSF) levels of amyloid-beta42, and significantly improved executive function on a Neuro-psychological Test Battery (NTB) within 12 weeks of treatment in patients with AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
The role of GLP-1 in neuronal activity and neurodegeneration
36/100 ✓ Peer-reviewed Drug development Vitamins and hormones
Key finding: Furthermore, recent research has shown that some GLP-1 analogues can cross the blood-brain barrier, including two that are on the market as a treatment for type 2 diabetes.
Full summary, score breakdown and related studies → Original source
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2010-01-01
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease
36/100 ✓ Peer-reviewed Drug development Journal of Alzheimer's disease : JAD
Key finding: Type 2 (T2) diabetes mellitus (DM) has been associated with an increased incidence of neurodegenerative disorders, including Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease
36/100 ✓ Peer-reviewed Drug development Journal of Alzheimer's disease : JAD
Key finding: We have previously reported anti-amyloidogenic effects of leptin using in vitro and in vivo models and, more recently, demonstrated the ability of leptin to reduce tau phosphorylation in neuronal cells. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
Clinical uses of melatonin: evaluation of human trials
36/100 ✓ Peer-reviewed Brain scans and imaging Current medicinal chemistry
Key finding: The conclusion of the current review is that the use of melatonin as an adjuvant therapy seems to be well funded for macular degeneration, glaucoma, protection of the gastric mucosa, irritable bowel syndrome, arterial hypertension, diabetes, side effects of chemotherapy and radiation in cancer patients or hemodialysis in patients with renal insufficiency and, especially, for sleep disorders of circadian etiology (jet lag, delayed sleep phase syndrome, sleep deterioration associated with aging, etc.) as well as in those related with neurological degenerative diseases (Alzheimer, etc.,) or Smith-Magenis syndrome.
Full summary, score breakdown and related studies → Original source
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2010-01-01
Structural brain changes in aging: courses, causes and cognitive consequences
40/100 ✓ Peer-reviewed Brain scans and imaging Reviews in the neurosciences
Key finding: The structure of the brain is constantly changing from birth throughout the lifetime, meaning that normal aging, free from dementia, is associated with structural brain changes.
Full summary, score breakdown and related studies → Original source
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2010-01-01
Computerized cognitive assessment in primary care to identify patients with suspected cognitive impairment
64/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease : JAD
Key finding: Tests currently used in primary care, such as the Mini-Mental State Examination, do not accurately assess patients with mild cognitive impairments, and other tests more suitable for this purpose require further validation and may be too time-consuming in the primary care setting. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines
36/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: These findings indicate that the Abeta in the brain of the aged canine exhibits patterns that mirror Abeta deposited in the human brain.
Full summary, score breakdown and related studies → Original source
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2010-01-01
Evaluation of CSF biomarkers as predictors of Alzheimer's disease: a clinical follow-up study of 4.7 years
47/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: MCI patients with both low Aβ42 and high tau levels had a substantially increased risk of developing AD (OR 20; 95% CI 6-58), even after adjustment for confounding factors.
Full summary, score breakdown and related studies → Original source
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2010-01-01
The amnestic syndrome of hippocampal type in Alzheimer's disease: an MRI study
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of Alzheimer's disease : JAD
Key finding: With VBM analysis, the total score on the FCSRT was correlated with left medial temporal lobe atrophy including the left hippocampus but also the thalami. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
Hippocampal pathology in schizophrenia
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Current topics in behavioral neurosciences
Key finding: The underlying cellular substrate is a subtle, yet functionally significant reduction of hippocampal interneurons. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
Raising the standard: palliative care in nursing homes
36/100 ✓ Peer-reviewed End-of-life care Health affairs (Project Hope)
Key finding: More than two-thirds of long-stay nursing home residents suffer from dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
The influence of nursing home culture on the use of feeding tubes
40/100 ✓ Peer-reviewed End-of-life care Archives of internal medicine
Key finding: The NH culture influences the approach to feeding in advanced cognitive impairment, whether by hand or placement of a feeding tube. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-01-01
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair
74/100 ✓ Peer-reviewed Clinical safety Mayo Clinic proceedings
Key finding: The use of light propofol sedation decreased the prevalence of postoperative delirium by 50% compared with deep sedation. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
Are certain lifestyle habits associated with lower Alzheimer's disease risk?
36/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: Studies have shown controversial results when it comes to the relation between the adherence to a Mediterranean diet and /or physical activity and the incidence of AD.
Full summary, score breakdown and related studies → Original source
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2010-01-01
Cognitive intervention programmes on patients affected by Mild Cognitive Impairment: a promising intervention tool for MCI?
40/100 ✓ Peer-reviewed Prevention trials The journal of nutrition, health & aging
Key finding: Though both traditional and computer-based cognitive intervention programmes seem to be effective, the computer-based ones present more advantages: 1) they could individualize the programme tailored to the patient's neuropsychological pattern and needs. 2) they permit the user to make an immediate objective comparison with data collected earlier and thus help in setting up a systematic training plan by providing instant value-free feedback. 3) they offer a possibility of a widescale dissemination. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-01-01
Targets for the prevention of dementia
43/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: One study suggested that the cognitive, physical, and social components of activity were of equal importance to cognitive outcomes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
Transporters in the brain endothelial barrier
36/100 ✓ Peer-reviewed Disease mechanisms Current medicinal chemistry
Key finding: It is also known that the Abeta:deposition is inversely correlated with P-gp expression in the brains of elderly non-demented humans. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-01
Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology
Key finding: Amyloid-beta accumulation was associated with expression of the Abeta influx transporter, the receptor for advanced glycation end-products (RAGEs) at the blood-brain barrier.
Full summary, score breakdown and related studies → Original source
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2010 no date recorded — placed by publication year
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
51/100 ✓ Peer-reviewed Genetics Alzheimer s Research & Therapy
Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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