Newest studies

The association of education and socioeconomic status with the Mini Mental State Examination and the clinical diagnosis of dementia in elderly people

40/100 ✓ Peer-reviewed Disparities Age and ageing

Key finding: Increasing age, lower socioeconomic group and less education were all found to be associated with lower scores on MMSE. +1 more finding

• Health Equity
• Diagnosis

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Insight for impairment in independent living skills in Alzheimer's disease and multi-infarct dementia

41/100 ✓ Peer-reviewed Caregiving Journal of clinical and experimental neuropsychology

Key finding: Pairwise comparisons at the .05 level revealed a significantly greater loss of insight for ILS impairment in AD patients as compared to both controls and MID patients. +2 more findings

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Dementia lacking distinctive histologic features: a common non-Alzheimer degenerative dementia

40/100 ✓ Peer-reviewed Clinical safety Neurology

Key finding: The psychometric findings of some of the patients were consistent with a "frontal" lobe dementia. +4 more findings

• Brain Biology

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Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

50/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

Key finding: The principal component of this extracellular amyloid is beta/A4, a peptide derived from a larger amyloid precursor protein (APP), which is actively expressed in brain and systemic organs. +3 more findings

Full summary, score breakdown and related studies → Original source

A prospective study of delirium in hospitalized elderly

49/100 ✓ Peer-reviewed How common it is JAMA

Key finding: Abnormal sodium levels, illness severity, dementia, fever or hypothermia, psychoactive drug use, and azotemia were associated with risk of delirium. +3 more findings

• Care Services

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Late neurological complications after prophylactic cranial irradiation in patients with small-cell lung cancer: the Toronto experience

44/100 ✓ Peer-reviewed Disparities Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Key finding: Metastasis to the CNS occurred significantly less often in patients who received prophylactic cranial irradiation (PCI) in a dose of 20 Gy in five equal fractions (two of 48), compared with patients who did not receive it (four of 10) (P less than .006). +3 more findings

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Senile dementia of Lewy body type. A clinically and neuropathologically distinct form of Lewy body dementia in the elderly

43/100 ✓ Peer-reviewed Getting a diagnosis Journal of the neurological sciences

Key finding: A dementing syndrome has been identified in a group of psychiatric cases aged 71-90 years, presenting initially with a subacute/acute confusional state, often fluctuating and associated with visual hallucinations and behavioural disturbances. +3 more findings

• Brain Biology
• Other Dementias

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Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins

40/100 ✓ Peer-reviewed Drug development Acta neuropathologica

Key finding: Our results demonstrate that Tau proteins are normal and major components of the somatodendritic domain and that Tau pathology, reflected by the presence of Tau 64 and 69, affects preferentially this domain during Alzheimer's disease.

• Brain Biology

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Optic nerve damage in Alzheimer's disease

36/100 ✓ Peer-reviewed Brain scans and imaging Ophthalmology

Key finding: Optic nerves from ten patients with Alzheimer's disease were histologically examined and compared with those from age-matched controls. +2 more findings

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Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia

46/100 ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica

Key finding: The ferritin accumulation was almost exclusively associated with the microglia, which appeared to have proliferated greatly. +3 more findings

• Brain Biology

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The Mini-Mental State Examination in the early diagnosis of Alzheimer's disease

47/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of neurology

Key finding: We administered the MMSE to 74 community-dwelling patients meeting criteria for probable Alzheimer's disease (AD) and 74 age- and education-matched controls. +3 more findings

• Diagnosis

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Study of spindle microtubule reassembly in cells from Alzheimer and Down syndrome patients following exposure to colcemid

30/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer disease and associated disorders

Key finding: Evidence indicates that microtubule assembly is impaired in AD. +3 more findings

• Down Syndrome
• Brain Biology

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Developmental and aging changes in the expression patterns of beta-amyloid in the brains of normal and Down syndrome cases

32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain & development

Key finding: The results indicate that the A4 protein is a developmental protein, and its reappearance in Alzheimer and adult Down syndrome brains may be related to the regeneration process.

• Down Syndrome
• Brain Biology

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Neuropathology of Down syndrome and Alzheimer disease

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics. Supplement

Key finding: Retrospective and prospective attempts to relate neuropathological lesions and clinical dementia in DS have produced conflicting results.

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

Clinical aspects of Down syndrome from infancy to adulthood

34/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics. Supplement

Key finding: During the subsequent childhood years a number of clinical conditions and disorders such as infectious diseases, increased nutritional intake, periodontitis, seizure disorders, sleep apnea, visual impairment, audiologic deficits, thyroid dysfunction, and skeletal problems usually occur at a higher prevalence. +4 more findings

• Down Syndrome

Full summary, score breakdown and related studies → Original source

The consequences of chromosome imbalance

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics. Supplement

Key finding: Thus, in Down syndrome, the presence of an extra copy of the proximal part of 21q22.3 appears to result in the typical physical phenotype--as defined principally in terms of the characteristic facial and hand anomalies and congenital heart defect--in addition to mental retardation. +1 more finding

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Germ cell tumors of the thalamus and the basal ganglia

37/100 ✓ Peer-reviewed Digital health tools Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Key finding: The plain CT finding was characterized by an irregularly defined, slightly high-density area frequently accompanied by central low-density areas without significant mass effect. +1 more finding

• Risk Factors

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The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity

58/100 ✓ Peer-reviewed How common it is Neurology

Key finding: Analysis of neuropsychological tests from 9 LBV subjects and 9 AD patients matched for age and degree of dementia revealed greater deficits in attention, fluency, and visuospatial processing in the LBV group. +1 more finding

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Sensitivity and specificity of standardized screens of cognitive impairment and dementia among elderly black and white community residents

50/100 ✓ Peer-reviewed Disparities Journal of clinical epidemiology

Key finding: Battery (42%, 69%), (5) Iowa Battery (26%, 69%) and (6) Kendrick Cognitive Tests (92%, 97%). +4 more findings

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Differential diagnosis and classification of apathy

48/100 ✓ Peer-reviewed Getting a diagnosis The American journal of psychiatry

Key finding: This paper discusses the definition of apathy, reviews its differential diagnosis, and proposes a classification for the conditions that may produce it. +4 more findings

• Diagnosis

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Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia

53/100 ✓ Peer-reviewed Treatments Current medical research and opinion

Key finding: Two indices of overall therapeutic benefit showed a trend for less deterioration in the active-treatment group than in the placebo group. +2 more findings

• Clinical Trials
• Treatments

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General and dramatic glial reaction in Alzheimer brains

47/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: The amount of GFAP was significantly higher than in brains from controls and other neurodegenerative disorders (mean of 11 times), even in brain regions usually free of AD lesions such as caudate nucleus, thalamus, cerebellum, or brainstem.

• Brain Biology

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Benzodiazepines of long and short elimination half-life and the risk of hip fracture

55/100 ✓ Peer-reviewed Health systems and care delivery JAMA

Key finding: Medical record review for a sample of 189 cases suggested that this finding was not due to confounding by dementia, ambulatory status, functional status, or body mass.

• Care Services
• Side Effects

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The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects

46/100 ✓ Peer-reviewed Risk genes beyond APOE Experimental neurology

Key finding: In the present study, we have used antibodies raised against portions of the amyloid protein precursor (APP) to map its normal distribution and to gain further insights into the events that lead to amyloid deposition. +3 more findings

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Construction of human chromosome 21-specific yeast artificial chromosomes

40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America

Key finding: YACs will aid the construction of a physical map of human chromosome 21 and the study of disorders associated with chromosome 21 such as Alzheimer disease and Down syndrome.

Full summary, score breakdown and related studies → Original source