Newest studies

Drug repurposing using meta-analysis of gene expression in Alzheimer's disease

70/100 ✓ Peer-reviewed Drug development Frontiers in neuroscience

Key finding: Reversal genes and the candidate compounds were identified by the leave-one-out cross-validation procedure. +2 more findings

• Treatments
• Genetics

Full summary, score breakdown and related studies → Original source

TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

53/100 ✓ Peer-reviewed TREM2 and immune genetics Neuron

Key finding: Variants in APOE and TREM2 increase AD risk. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline

76/100 ✓ Peer-reviewed Mild cognitive impairment Nature medicine

Key finding: Cox proportional-hazards models showed a substantially increased risk for progression to mild cognitive impairment in the A + T NEO-T + (hazard ratio (HR) = 19.2, 95% confidence interval (CI) = 10.9-33.7), A + T MTL + (HR = 14.6, 95% CI = 8.1-26.4) and A + T - (HR = 2.4, 95% CI = 1.4-4.3) groups versus the A - T - (reference) group. +2 more findings

• Early Stage
• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

45/100 ✓ Peer-reviewed Genetics Nature

Key finding: We identify a subpopulation of PBMs that express high levels of CD163 and LYVE1 (scavenger receptor proteins), closely associated with the brain arterial tree, and show that LYVE1 + PBMs regulate arterial motion that drives CSF flow. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Therapeutics for mitochondrial dysfunction-linked diseases in Down syndrome

35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Mitochondrion

Key finding: Collectively, the mitochondrial abnormalities and altered energy metabolism perturbs several signaling pathways, particularly related to neurogenesis, which are directly associated with cognitive development and early onset of AD in individuals with DS.

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

Can Alzheimer's Disease Be Secondary to Type-2 Diabetes Mellitus?

41/100 ✓ Peer-reviewed Risk factors Cureus

Key finding: First, it was shown that insulin receptors are present in the brain, namely the hippocampus. +2 more findings

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Unsupervised mobile app-based cognitive testing in a population-based study of older adults born 1944

50/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in digital health

Key finding: MDT-OS and ORR-LDR were weakly-to-moderately correlated with the Preclinical Alzheimer's Cognitive Composite (PACC5) (r = 0.3-0.44, p < .001) and with several other measures of episodic memory, processing speed, and executive function. +4 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies

54/100 ✓ Peer-reviewed How common it is Molecular neurodegeneration

Key finding: While the ε4 allele of the APOE gene significantly increases AD risk, the ε2 allele is protective relative to the common ε3 allele.

• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source

The importance of estradiol for body weight regulation in women

43/100 ✓ Peer-reviewed Drug development Frontiers in endocrinology

Key finding: It is associated with increased menstrual irregularity, ovulatory dysfunction, development of insulin resistance and infertility.

• Risk Factors

Full summary, score breakdown and related studies → Original source

Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology

65/100 ✓ Peer-reviewed Long-term cohort studies EBioMedicine

Key finding: Hearing impairment was recently identified as the most prominent risk factor for dementia. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Vascular endothelial-cadherin as a marker of endothelial injury in preclinical Alzheimer disease

51/100 ✓ Peer-reviewed Biomarkers Annals of clinical and translational neurology

Key finding: Our results support the utility of CSF VEC as a marker of endothelial injury in AD and highlight the importance of endothelial injury as an early pathology that contributes to cognitive impairment in even the earliest preclinical stages. +2 more findings

• Biomarkers
• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Disease specific and nonspecific metabolic brain networks in behavioral variant of frontotemporal dementia

58/100 ✓ Peer-reviewed Brain scans and imaging Human brain mapping

Key finding: Its expression in bvFTD patients was significantly higher compared to HC and other dementia syndromes (p < .0004), correlated with cognitive decline (p = .0001), and increased over time in longitudinal cohort (p = .0007). +3 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Diverse limbic comorbidities cause limbic and temporal atrophy in lewy body disease

41/100 ✓ Peer-reviewed Brain tissue and pathology Parkinsonism & related disorders

Key finding: The mean age at antemortem magnetic resonance imaging of the mLBD patients was higher than that of the pLBD patients (84.3 ± 3.9 vs. 76.5 ± 10.5; p = .046). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease

57/100 ✓ Peer-reviewed Treatments Nature communications

Key finding: Using human cross-sectional and longitudinal neuroimaging and cognitive assessment data, we show that in early stages of AD, increased concentration of soluble CSF p-tau is strongly associated with accumulation of insoluble tau aggregates across the brain, and CSF p-tau levels mediate the effect of Aβ on tau aggregation. +2 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Attitudes toward Alzheimer's disease and dementia caregiving and health outcomes: Racial and ethnic differences

48/100 ✓ Peer-reviewed Disparities Geriatric nursing (New York, N.Y.)

Key finding: There were significant racial/ethnic differences in caregivers' attitudes toward dementia caregiving, health-related quality of life, and total severity scores of symptoms (p < .01). +1 more finding

• Health Equity
• Caregiving

Full summary, score breakdown and related studies → Original source

SPARE-Tau: A flortaucipir machine-learning derived early predictor of cognitive decline

61/100 ✓ Peer-reviewed Brain scans and imaging PloS one

Key finding: Compared to CSF p-tau, meta-temporal, and averaged Braak tau PET ROIs, SPARE-Tau showed the strongest association with baseline ADAS-cog13 scores and diagnosis. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan

41/100 ✓ Peer-reviewed Genetics Cell stem cell

Key finding: Detailed analyses of astrocytes, oligodendrocyte lineages, and microglia identified subpopulations with distinct molecular signatures and revealed their association with specific physiological functions, age-dependent changes in abundance, and disease relevance. +2 more findings

Full summary, score breakdown and related studies → Original source

The association between cerebrospinal ferritin and soluble triggering receptor expressed on myeloid cells 2 along Alzheimer's continuum

48/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in neurology

Key finding: Brain iron accumulation, which is indicated in the cerebrospinal fluid (CSF) ferritin, is associated with the development of Alzheimer's Disease (AD). +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Sex-specific biomarkers in Alzheimer's disease progression: Framingham Heart Study

75/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: During 11 years of follow-up, women were 96% more likely than men to be diagnosed with clinical AD dementia after adjusting for age and education in the younger age group 60 to 70 years (n = 946; 95% confidence interval [CI], 1.08 to 3.56) although not in the older age group (70+) (n = 452; hazard ratio = 0.98; 95% CI, 0.68 to 1.53). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Association of cognitive function with Neurofilament light chain in the aqueous humor of human eye

64/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: NfL, Aβ40, Aβ42, GFAP, and p-tau181 were detected in all AH samples by Simoa platform. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults

61/100 ✓ Peer-reviewed Tau biomarkers Brain communications

Key finding: Epidemiological and experimental data point to sleep abnormalities contributing to the risk of Alzheimer's disease. +3 more findings

• Biomarkers
• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: A cross sectional observational study

62/100 ✓ Peer-reviewed Digital health tools Lancet regional health. Americas

Key finding: A fully automated computational approach included classical statistical methods, support vector machine procedures, and machine learning techniques (random forest and sequential feature selection procedures). +3 more findings

• Health Equity
• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Risk factors for dementia in Brazil: Differences by region and race

61/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Brazil's potential for dementia prevention is higher than in HIC.

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Fast and Accurate Amyloid Brain PET Quantification Without MRI Using Deep Neural Networks

44/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Quantification results using the proposed deep learning-based method showed stronger correlations with the FreeSurfer estimates than SPM-based SN using MRI did. +4 more findings

• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

The intestinal barrier in disorders of the central nervous system

40/100 ✓ Peer-reviewed Disease mechanisms The lancet. Gastroenterology & hepatology

Key finding: Mounting evidence now suggests that the intestinal barrier is compromised not only in digestive disorders, but also in disorders of the central nervous system (CNS), such as Parkinson's disease, autism spectrum disorder, depression, multiple sclerosis, and Alzheimer's disease.

Full summary, score breakdown and related studies → Original source