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55/100

✓ Peer-reviewed alzhub usefulness score 55 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

Importance Cognitive dysfunction is a common feature among patients with parkinsonism, including Parkinson disease (PD). However, there is a scarcity of data on cognitive functioning before parkinsonism diagnosis, a stage at which patients may still respond to putative disease-modifying interventions. Objective To assess whether poor cognitive functioning is associated with an increased risk of parkinsonism.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Darweesh, S. K. L., Wolters, F. J., Postuma, R. B., Stricker, B. H., Hofman, A., Koudstaal, P. J., et al. (2017). Association Between Poor Cognitive Functioning and Risk of Incident Parkinsonism: The Rotterdam Study. JAMA neurology. https://doi.org/10.1001/jamaneurol.2017.2248

Vancouver

Darweesh SKL, Wolters FJ, Postuma RB, Stricker BH, Hofman A, Koudstaal PJ, et al. Association Between Poor Cognitive Functioning and Risk of Incident Parkinsonism: The Rotterdam Study. JAMA neurology. 2017. doi:10.1001/jamaneurol.2017.2248. PMID: 28973176.

BibTeX

@article{darweesh2017-28973176,
  author  = {Darweesh, S. K. L. and Wolters, F. J. and Postuma, R. B. and Stricker, B. H. and Hofman, A. and Koudstaal, P. J. and Ikram, M. K. and Ikram, M. A.},
  title   = {{Association Between Poor Cognitive Functioning and Risk of Incident Parkinsonism: The Rotterdam Study}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2017.2248},
  pmid    = {28973176},
  url     = {https://doi.org/10.1001/jamaneurol.2017.2248}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

However, there is a scarcity of data on cognitive functioning before parkinsonism diagnosis, a stage at which patients may still respond to putative disease-modifying interventions.
Objective To assess whether poor cognitive functioning is associated with an increased risk of parkinsonism.
Design, setting, and participants Between January 8, 2002, and December 14, 2008, baseline cognitive function was assessed in 7386 participants of the Rotterdam Study who were free of parkinsonism and dementia.
Four tests were administered (Stroop color word test, letter-digit substitution, verbal fluency, and word learning) and a global cognition score was derived from principal component analysis.

Why it matters

In 7,386 participants of the Rotterdam Study who were free of parkinsonism and dementia at baseline, poor cognitive functioning was assessed for its link to later parkinsonism. The study aimed to see if cognitive problems appear before a parkinsonism diagnosis, a stage when treatments might still be effective.

Study details

Participants7,386
Effect size57.4%; 1.1%; 72.2%
Evidence strengthLow

How this study scored 55/100

Published in a leading specialty journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	3 / 4	7,386 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 73 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	6.6 citations a year over 11 year(s) since 2017
Impact for its field and year	3 / 6	Cited 4.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	2 / 4	Cited 22 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career)
Institution's track record	3 / 3	Harvard University: institution h-index 3,235 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28973176)
Free to read	0 / 2	Behind a paywall — scores zero
Total	55 / 100	—

What each of these 20 components measures, and what this score is not →

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