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62/100

✓ Peer-reviewed alzhub usefulness score 62 out of 100. Caregiving

Topic: Amyloid, tau and blood-test diagnosis

The following 2 regions for tau burden were identified: the entorhinal cortex, which exhibits early signs of tauopathy, and the inferior temporal region, which is more closely associated with AD-related pathologic mechanisms. Results Of the 133 participants, 75 (56.3%) were women and 58 (43.6%) were men; mean (SD) age was 76 (6.9) years (range, 55-90 years). Greater SCD was associated with increasing entorhinal cortical tau burden (β = 0.35; 95% CI, 0.19-.52; P Conclusions and relevance Subjective cognitive decline is indicative of accumulation of early tauopathy in the medial temporal lobe, specifically in the entorhinal cortex, and to a lesser extent, elevated global levels of Aβ. Our findings suggest multiple underlying pathways that motivate SCD that do not necessarily interact to influence SCD endorsement.

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APA 7th

Buckley, R. F., Hanseeuw, B., Schultz, A. P., Vannini, P., Aghjayan, S. L., Properzi, M. J., et al. (2017). Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden. JAMA neurology. https://doi.org/10.1001/jamaneurol.2017.2216

Vancouver

Buckley RF, Hanseeuw B, Schultz AP, Vannini P, Aghjayan SL, Properzi MJ, et al. Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden. JAMA neurology. 2017. doi:10.1001/jamaneurol.2017.2216. PMID: 28973551.

BibTeX

@article{buckley2017-28973551,
  author  = {Buckley, R. F. and Hanseeuw, B. and Schultz, A. P. and Vannini, P. and Aghjayan, S. L. and Properzi, M. J. and Jackson, J. D. and Mormino, E. C. and others},
  title   = {{Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2017.2216},
  pmid    = {28973551},
  url     = {https://doi.org/10.1001/jamaneurol.2017.2216}
}

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Key findings

The following 2 regions for tau burden were identified: the entorhinal cortex, which exhibits early signs of tauopathy, and the inferior temporal region, which is more closely associated with AD-related pathologic mechanisms.
Results Of the 133 participants, 75 (56.3%) were women and 58 (43.6%) were men; mean (SD) age was 76 (6.9) years (range, 55-90 years).
Greater SCD was associated with increasing entorhinal cortical tau burden (β = 0.35; 95% CI, 0.19-.52; P < .001) and Aβ burden (β = 0.24; 95% CI, 0.08-.40; P = .005), but not inferior temporal tau burden (β = 0.10; 95% CI, -0.08 to 0.28; P = .27).
Our findings suggest multiple underlying pathways that motivate SCD that do not necessarily interact to influence SCD endorsement.

Why it matters

In 133 participants, greater subjective cognitive decline was associated with increasing tau burden in the entorhinal cortex, independent of global amyloid burden. This suggests subjective cognitive decline may reflect early tau accumulation in the medial temporal lobe.

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Study details

Study designcross-sectional
Participants133
Effect size56.3%; 43.6%; 29.3%
Evidence strengthLow

How this study scored 62/100

Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	2 / 4	133 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 173 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	15.7 citations a year over 11 year(s) since 2017
Impact for its field and year	4 / 6	Cited 14.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 7 other studies in this library
Still being cited	3 / 4	Cited 50 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Rebecca England Amariglio: h-index 57 (OpenAlex, whole career)
Institution's track record	3 / 3	Harvard University: institution h-index 3,235 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 8 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28973551)
Free to read	0 / 2	Behind a paywall — scores zero
Total	62 / 100	—

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