Newest studies

Case-Based fMRI Analysis after Cognitive Rehabilitation in MS: A Novel Approach

40/100 ✓ Peer-reviewed Prevention trials Frontiers in neurology

Key finding: The occurrence of different and opposed response patterns after the same training indicates a risk in applying classical group statistics. +3 more findings

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Is There a Need for Early Palliative Care in Patients With Life-Limiting Illnesses? Interview Study With Patients About Experienced Care Needs From Diagnosis Onward

36/100 ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

Key finding: The early integration of specialist palliative care has been shown to benefit the quality of life of patients with advanced cancer. +3 more findings

• End-of-Life Care
• Diagnosis

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Neuroplastic effects of combined computerized physical and cognitive training in elderly individuals at risk for dementia: an eLORETA controlled study on resting states

66/100 ✓ Peer-reviewed Prevention trials Neural plasticity

Key finding: A significant training effect was identified only after the combined training scheme: a decrease in the post- compared to pre-training activity of precuneus/posterior cingulate cortex in delta, theta, and beta bands. +1 more finding

• Lifestyle

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Direct medical costs and source of cost differences across the spectrum of cognitive decline: a population-based study

40/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Cost estimates did not differ significantly between CN and MCI. +2 more findings

• Policy
• Early Stage

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In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging

43/100 ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences of the United States of America

Key finding: In this work, we used [F-18]FDDNP PET to detect brain patterns of neuropathology distribution in retired professional American football players with suspected CTE (n = 14) and compared results with those of cognitively intact controls (n = 28) and patients with Alzheimer's dementia (AD) (n = 24), a disease that has been cognitively associated with CTE. [F-18]FDDNP PET imaging results in the retired players suggested the presence of neuropathological patterns consistent with models of concussion wherein brainstem white matter tracts undergo early axonal damage and cumulative axonal injuries along subcortical, limbic, and cortical brain circuitries supporting mood, emotions, and behavior.

• Brain Scans
• Other Dementias
• Brain Biology

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Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

43/100 ✓ Peer-reviewed Mild cognitive impairment Biochimica et biophysica acta

Key finding: Oxidative stress and endoplasmic reticulum (ER) stress have been associated with Alzheimer's disease (AD) progression. +2 more findings

• Early Stage
• Brain Biology

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The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species

40/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Further analysis of brain-derived ∼7 kDa Aβ species, the mechanism by which they assemble and the structures they form should reveal therapeutic and diagnostic opportunities.

• Brain Biology

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Synaptic dysfunction and septin protein family members in neurodegenerative diseases

38/100 ✓ Peer-reviewed Disease mechanisms Molecular neurodegeneration

Key finding: Recent research has identified neurodegenerative disease-related changes in protein accumulation and aggregation, gene expression, and protein functions, which may contribute to imbalanced synaptic function. +4 more findings

• Brain Biology
• Other Dementias
• Caregiving

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Tau immunotherapy for Alzheimer's disease

36/100 ✓ Peer-reviewed Drug development Trends in molecular medicine

Key finding: Targeting pathological tau protein in Alzheimer's disease (AD) and related tauopathies has shown great potential in animal models. +3 more findings

• Brain Biology

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Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?

55/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: This study suggests that information obtained from evaluating a subgroup of AD or MCI subject using second-generation TSPO tracers can be translated to the entire AD and MCI population. +4 more findings

• Genetics
• Brain Biology

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Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression

60/100 ✓ Peer-reviewed Cognitive tests and assessment BMJ open

Key finding: Online literature databases and trial registers, previous systematic reviews and leading journals were searched for relevant randomised controlled trials. +3 more findings

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Exercise and the heart: the good, the bad, and the ugly

48/100 ✓ Peer-reviewed Prevention and risk European heart journal

Key finding: In parallel with the extraordinary athletic milieu of physical performances previously considered unachievable, there is emerging data indicating that long-standing vigorous exercise may be associated with adverse electrical and structural remodelling in otherwise normal hearts.

• Lifestyle

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Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery: Design and Methods

64/100 ✓ Peer-reviewed Clinical trials Journal of Neurotrauma

Key finding: An evaluation of the neuroprotection intervention studies conducted over the last 30 years has indicated that a limited understanding of the underlying biological concepts and methodological design flaws are the major reasons for the failure of pharmacological agents to demonstrate efficacy. +1 more finding

• Clinical Trials

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Identifying patients with Alzheimer's disease using resting-state fMRI and graph theory

36/100 ✓ Peer-reviewed Digital health tools Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Key finding: Classification based on the resting-state fMRI can be used as a non-invasive and automatic tool to diagnosis of Alzheimer's disease. +3 more findings

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Amyloid biomarkers in Alzheimer's disease

36/100 ✓ Peer-reviewed Tau biomarkers Trends in pharmacological sciences

Key finding: Biomarkers to monitor Aβ metabolism and aggregation directly in patients are important for further detailed study of the involvement of Aβ in disease pathogenesis and to monitor the biochemical effect of drugs targeting Aβ in clinical trials. +4 more findings

• Biomarkers
• Treatments

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Care in the last year of life for community patients with heart failure

55/100 ✓ Peer-reviewed End-of-life care Circulation. Heart failure

Key finding: Although patient factors remain associated with differential healthcare utilization at the end of life, utilization declined over time and use of palliative care services increased. +2 more findings

• End-of-Life Care

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End-of-life issues in advanced dementia: Part 1: goals of care, decision-making process, and family education

36/100 ✓ Peer-reviewed End-of-life care Canadian family physician Medecin de famille canadien

Key finding: Physicians should consider advanced dementia as a terminal disease for which there is a continuum of care that goes from palliative care with life-extending measures to symptomatic interventions only. +4 more findings

• End-of-Life Care
• Caregiving

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Recognizing acute delirium as part of your routine [RADAR]: a validation study

48/100 ✓ Peer-reviewed End-of-life care BMC nursing

Key finding: The RADAR tool proved to be efficient, reliable, sensitive and very well accepted by nursing staff. +2 more findings

• Care Services

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TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

50/100 ✓ Peer-reviewed Brain tissue and pathology Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Key finding: However, recent studies show that almost all cases of ALS, as well as tau-negative frontotemporal dementia (FTD), share a common neuropathology characterized by the deposition of TAR-DNA binding protein (TDP)-43-positive protein inclusions, offering an attractive target for the design and testing of novel therapeutics. +3 more findings

• Brain Biology
• Treatments

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Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease

48/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: The brain's immune cells migrate to and invest their processes within Aβ plaques but are unable to efficiently phagocytose and clear plaques from the brain. +3 more findings

• Genetics
• Brain Biology

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Effects of low blood pressure in cognitively impaired elderly patients treated with antihypertensive drugs

64/100 ✓ Peer-reviewed Mild cognitive impairment JAMA internal medicine

Key finding: Low daytime SBP was independently associated with a greater progression of cognitive decline in older patients with dementia and MCI among those treated with AHDs. +4 more findings

• Treatments
• Early Stage
• Risk Factors

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Prediction of brain age suggests accelerated atrophy after traumatic brain injury

52/100 ✓ Peer-reviewed Digital health tools Annals of neurology

Key finding: TBI patients' brains were estimated to be older than their chronological age. +2 more findings

• Brain Scans
• Risk Factors

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Itch prevalence and characteristics in a Hispanic geriatric population: a comprehensive study using a standardized itch questionnaire

53/100 ✓ Peer-reviewed Disparities Acta dermato-venereologica

Key finding: Chronic itch is a common problem in the studied Hispanic geriatric population, and its presence significantly correlates with xerosis, diabetes, and venous insufficiency.

• Health Equity

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Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals

51/100 ✓ Peer-reviewed Prevention and risk The journal of nutrition, health & aging

Key finding: None of the participants were diabetics, smokers, or met criteria for obesity. +3 more findings

• Prevention
• Biomarkers
• Brain Scans

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Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument

66/100 ✓ Peer-reviewed Genetics JAMA neurology

Key finding: At 48 months, group differences between clinical progressors and non-progressors were significant for self (2.13, SE=0.45, P Conclusions and relevance Demonstrating long-term clinical benefit will be critical for the success of recently launched secondary prevention trials.

• Genetics

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